1. Gịnị bụ Pterostilbene?

Pterostilbene bụ kemịkal dị mkpa nke ekepụtara n'oge ndụ ụfọdụ osisi dịka ụzọ isi lụso ọrịa ọgụ. Otutu a dika ogige ozo a maara dika Resveratrol ma di nfe na ntinye ihe ozo. Ihe mgbakwunye Pterostilbene bụ nnukwu ihe ọkụkụ. Nke a pụtara na ha nwere ike ịbanye ha n’ahụ ngwa ngwa na ngwa ngwa, enweghị mgbada na usoro mgbaze. Pterostilbene ntụ ntụ dịkwa mma, ma ọkara ndụ ya dị mkpụmkpụ ebe ọ bụ na ọ dị n'okpuru nkeji 100.

Pterostilbene isi mmalite nri

Pterostilbene ebe nri si gunyere bred breeki, almọnd, kranberị, mulberries, ahụekere, mmanya na-acha ọbara ọbara, mkpụrụ vaịn na-acha uhie uhie, akwụkwọ osisi grape, ogbugbo osisi kino Indian, red sandalwood, na koko. Agbanyeghị, bred bụ nri Pterostilbene kachasị elu, mana ọnụọgụ mkpụrụ osisi pọpụl nwere ka pere mpe ma e jiri ya na nri Pterostilbene. Ekwenyere na enwere ihe ndị na-acha anụnụ anụnụ nke pterostilbene dị na nanogram 99 ruo 52, na gram bred ọ bụla.

pterostilbene-uzuzu

2.Usoro Pterostilbene

Usoro Pterostilbene dị iche na nke resveratrol. Pterostilbene compound bụ ihe kachasị ike Stilbene. Uru Pterostilbene dị iche iche na-arụkọ ọrụ kwekọrọ na usoro usoro dị iche iche. Omume ọgwụ nke trans-pterostilbene gụnyere antineoplastic, antioxidant, na mgbochi mkpali.

Pterostilbene na-egosi ọrụ antifungal dị irè nke nwere ike okpukpu iri karịa ike resveratrol. Pterostilbene na-egosipụtakwa nsonaazụ antiviral. Nchebe ahịhịa sitere n'ọtụtụ nje yiri ka ọ bụ usoro dị mkpa nke stilbenes, gụnyere Pterostilbene, ọrụ ndị a gbakwara anụmanụ na ụmụ mmadụ aka.

Pterostilbene na-egosikwa mmetụta anticancer site na ọtụtụ usoro molekụla. Nchọpụta emere nyocha Pterostilbene na -eme ihe bụ mkpụrụ ndụ ihe na - egbochi mkpụgharị mkpụrụ ndụ, mgbanwe nke ụzọ transduction ụzọ, oncogenes, mkpụrụ ndụ ihe dị iche, yana mkpụrụ ndụ ịhazi mkpụrụ ndụ.

Ngwongwo antioxidative nke Pterostilbene dị iche na nke resveratrol. Na resveratrol, otu hydroxyl atọ ahụ kewapụrụ ROS (ụdị oxygen na-emeghachi omume) na lymphoblasts dịpụrụ adịpụ na ọbara dum mgbe Pterostilbene, nke nwere 1 hydroxyl otu na ìgwè abụọ methoxy na-ebelata ROS extracellular. Ntughari nke ihe nke antioxidation na-enyere aka iji Pterostilbene ntụ ntụ iji mee ka ụdị oxygen oxygen extracellular extracellular, nke na-akpata mbibi anụ ahụ n'oge mbufụt na-adịghị ala ala.

N'okpuru ebe a, usoro pterostilbene dị iche iche nke ime ihe tụlere na nkọwapụta;

Usoro Pterostilbene nke ime ihe; Sirtuin ebighị

Pterostilbene na-akpali ụzọ SIRT1 na-enye akara na sel nke na-enye nchebe pụọ na mmebi cellular, si otú a na-eme ya. Zọ a na - akwalite ngosipụta p53. P53 bụ protein na-echebe DNA pụọ na mmebi ma na-echebe mkpụrụ ndụ pụọ na mmụkọ nke nwere ike ibute kansa.

SIRT1 nwere ike igbochi gị mmebi na mmebi nke sel, nke na-aga n’ihu mgbe ị na-etolite.

Mmetụta Ọ Na-egbochi Ahụhụ

Ọtụtụ ọmụmụ egosila na pterostilbene chemical compound na-ebelata mbufụt nke TNF-alfa (tumor necrosis factor-alfa) na-achịkwa. Ihe nrụgide Oxidative na-ebute mbufụt; Pterostilbene na-egbochi interleukin-1b na TNF-alpha site na ibelata ụdị oxygen ndị na-emeghachi omume.

Ihe nchekwa a na - echekwa nchekasị n'ime akụkụ nke akụrụngwa cellular akpọrọ ER (endoplasmic reticulum). N'ime nyocha, mgbe ekpughere akwara nke arịa ọbara ọbara na Pterostilbene ntụ ntụ, akwara ha anabataghị akara mbufụt, ha apụtaghị na ọ dị ọkụ.

Usoro Pterostilbene nke ime ihe; Mmetụta Ọrịa Ọrịa Cancer

N'ụzọ dị ịtụnanya, na -ebelata nrụgide ER (endoplasmic reticulum) na oghere nke arịa ọbara, Pterostilbene na-akwalite nrụgide na endoplasmic reticulum nke mkpụrụ ndụ cancer akpịrị. Ya, ya mere, na-emebi nke ọma mkpụrụ ndụ kansa ma na - echekwa nchekasị akwara dị na sel nke ahụ ike.

N’ime mkpụrụ ndụ kansa (glioma) mkpụrụ ndụ kansa, Pterostilbene na-ebelata Bcl-2 ma bulie Bax; mgbanwe ndị a na - akwalite akara nke mkpụrụ ndụ "igbu onwe ya" na - akpata mkpụrụ ndụ akwara azụ ma ọ bụ ụbụrụ nwụrụ.

Mkpụrụ ndụ cancer na-eji okporo ụzọ akpọrọ Notch-1 mee ihe iji gbochie onwe ha ịme ọgwụ ọgwụ chemotherapy, gụnyere oxaliplatin na fluorouracil. Pterostilbene na-egbochi notch-1 na-amigide na-eme ka ọnụọgụ ọnụnụ ndị ahụ nwee mmetụta ọsọ ọsọ na ọgwụgwọ site na mmiri ọgwụ.

Pterostilbene na-ebelata mmepụta nke ọtụtụ ọgwụ na-akwalite ọrịa kansa, gụnyere MUC1, b-catenin, Sox2, NF-κB, na CD133. Ngbakwunye mmetụta ndị a na-ebelata mbufụt ma mee ka ọ bụrụ ihe na-agaghị ekwe omume maka uto mkpụrụ ndụ cancer.

neuroprotection

Pterostilbene nwere ike nwaa mpaghara mpaghara hippocampus nke ụbụrụ na-ahọrọ. N'ebe a, ọ na - akwalite CREB (protein nzaghachi na-ejikọ protein), BDNF (ihe na-akpata ụbụrụ neurotrophic), yana MAPK (protein mitogen-activates protein).

Ihe nchebe atọ a nyere aka neurons n'ịba ụba, na-eto ma na-aza nke ọma na gburugburu ha. Nkpagbu ọgwụ SNRI na-achọkwa ụzọ ndị a.

Pterostilbene na - akwalitekwa protein nke a na - akpọ Nrf2 na hippocampus, nke na - akwalite ngosipụta nke protein antioxidant.

Pterostilbene na-egbochi ahụ megide ọrịa Alzheimer site na ịnye ụbụrụ nchebe megide beta-amyloid (Aβ). Ọ na - eme nke a site na ịgụnye Akt na PI3K, protein abụọ na - akwado uto neuron, ebe nchekwa, na mmụta.

3. Pterostilbene ntụ ntụ bara uru

A tụlere n'okpuru ebe a bụ atọ kacha mkpa pterostilbene ntụ ntụ uru;

pterostilbene-ntụ ntụ-2

i. Pterostilbene dị ka nootropics

Ka anyị na-eto, usoro echiche ọhụrụ na - esikwu ike n’usoro, icheta ihe na - esikwu ike ịnweta. Enweghị ike ịrụ ọrụ ọgụgụ isi kwesịrị na-ebelata kwa. Pterostilbene nwere ike inye aka n'ịmepụta mpaghara agbatịghachi nke akwara afọ ọ bụla.

Pterostilbene bụ nootropic siri ike, nke na-enyere aka na ntụrụndụ na nkwalite cognition. A na-ewere ya ugboro ugboro tupu arụ ọrụ tupu ike ya inye aka na vasodilation nke arịa ọbara. Ya mere, na-enye mmetuta yiri nke ihe ndị ọzọ na-eme ka nitric oxide na-eme ka ihe ndị ọzọ dị mma.

Pterostilbene nootropic uru ekwenyere na ọ bụ n'ihi ike ya ịkwalite ogo dopamine. Na mkpanaka, Pterostilbene belatara nchegbu ma mee ka ọnọdụ ahụ kawanye mma. N'ime nyocha metụtara akarị agadi, pterostilbene mmeju welie ọkwa dopamine ma nwekwaa nkwalite. Ọzọkwa, mgbe emere Pterostilbene n'ụdị ụbụrụ hippocampus, ncheta ọrụ ha bịara kawanye mma.

Na omumu ihe ozo banyere oke, Pterostilbene meputara uto sel ohuru na hippocampus. Ọzọkwa, a na-enweta mkpụrụ ndụ stem ndị a na-ahụ site na ụbụrụ ụmụ irighiri ihe ngwa ngwa mgbe ekpughere ha na Pterostilbene.

Dabere na ọmụmụ sel, pterostilbene ntụ ntụ egbochi MAO-B (monoamine oxidase B) ma na-akwalite dopamine dị na ụbụrụ anyị. Ihe omume a yiri ọgwụ ndị na-agwọ ọrịa Parkinson, dị ka rasagiline, safinamide, na selegiline. N'ime nyocha, Pterostilbene na-echebekwa neurons megide mmebi metụtara AD (Ọrịa Alzheimer).

A kwenyekwara na ikike ịchịkwa nchekasị Pterostilbene bụ n'ihi ikike ya igbochi monoamine oxidase B. N'ime otu nnyocha, Pterostilbene gosipụtara ọrụ anxiolytic na abụọ na otu mg / kg doses. Ọrụ anxiolytic nke ogige ahụ yiri nke diazepam n'otu na mg / kg abụọ na EPM.

ii. Pterostilbene na Ibu

Otu nnyocha nyochara ikike nke Pterostilbene nwere ike ijikwa oke ibu gosipụtara na enwere njikọ dị n'etiti mmechi pterostilbene na njikwa ibu. Ndị ọkà mmụta sayensị ahụ kwenyere na ntụ ntụ Pterostilbene nwere ike imetụta ọkwa oke abụba n'ihi ikike ya belata lipogenesis. Lipogenesis bụ usoro nke ịmepụta sel abụba gabigara ókè. Pterostilbene nwekwara na - akwalite oke abụba ma ọ bụ oke abụba n’imeju.

N'ime nyocha metụtara ndị agadi nọ n'etiti ha nwere kọlestrọl dị elu, otu ndị sonyere na-adịghị a choụ ọgwụ cholesterol kwụsịrị ibu ka ha na-a supụ ọgwụ pterostilbene. Nsonaazụ ndị a mere ihe tụrụ ndị na-eme nchọpụta ahụ anya n'ihi na emeghị nchọpụta a iji tụọ pterostilbene mgbakwunye dị ka ihe enyemaka belata.

Ihe omumu anumanu na akwara gosiputara na pterostilbene nwere ike inye aka mee ka nnabata insulin mara. Ihe Pterostilbene na-eme bụ na ọ na-egbochi usoro ịtụgharị sugne ịbụ abụba. Ọ na - egbochi mkpụrụ ndụ abụba na - eto ma na - aba ụba.

Pterostilbene na - agbanwe gut flora mejupụtara na eriri afọ ma na - enyere aka na mgbaze nri.

Mkpuchi nke Pterostilbene nyere nwere ahịhịa na -emekwu ahụ ike na nnukwu agbam ume na Akkermansia muciniphila. A. muciniphila bụ ụdị nje na-apụta na-egbochi mbufụt dị ala, oke ibu, yana ọrịa shuga. Nje bacteria a abụrụla nnukwu ihe nyocha gbasara probiotic n'oge na-adịbeghị anya.

iii. Pterostilbene na-akwalite ọgbụgba

A na-ejikọ uru Pterostilbene na kemịkalụ bio bio nke akpọ Trans-pterostilbene. E gosiputawo mmiri ọgwụ a iji belata mbufụt, ịgbagha ihu abụọ, ma mee ka ọrịrị ọbara kwụsie ike. Na vivo na inyocha ọmụmụ na-akwado ọgwụ mgbochi Pterostilbene na ọgwụgwọ. Ihe kemịkal a na-arụkwa ọrụ dị ka ihe mgbochi caloric, nke na-akpali ahụ ịhapụ biochemicals, gụnyere adiponectin na-eme ka usoro ịka nká na-ebelata mgbe a na-akwalite ọgwụgwọ.

Ihe amara a maka ịka nká bụ ihe a na-ahụkarị maka ichebe megide ọrịa ndị metụtara afọ, wee si otú a na-agbatị ndụ. Na mkpanaka, obere doses nke kemịkalụ ala ndị a belata ihe mgbaàmà metụtara ịka nká. Ọmụmụ ihe ahụ tụrụ aro na iri ọtụtụ nri pterostilbene dị ka mkpụrụ osisi bred nwere ike igbu oge ịma aka ahụike metụtara agadi, gụnyere dementia na kansa.

pterostilbene-ntụ ntụ-3

4. Pterostilbene na resveratrol

Obi abụọ adịghị ya na Pterostilbene na resveratrol nwere njikọ chiri anya. A maara Resveratrol dị ka kemịkalụ na-egbu egbu na mmanya na-acha ọbara ọbara na mkpụrụ vaịn.

Abamuru ahụike nke resveratrol yiri nke Pterostilbene ma tinye nchebe pụọ na ọrịa Alzheimer, mmetụta anticancer, nkwalite ike, mmụba mgbochi, ikike ịmị ọrịa shuga, na uru obi.

Pterostilbene bụ nke yiri nke mmiri ọgwụ resveratrol, mana nyocha ekwuola na Pterostilbene nwere ike karịa ike resveratrol na njikwa ụfọdụ ọnọdụ ahụ ike. Pterostilbene egosiputala ikike dị ukwuu n'ịkwalite ọrụ ọgụgụ isi, ahụike obi, na ọkwa glucose.

Ndụ ọkara nke Pterostilbene dịkwa mkpụmkpụ karịa ọkara nke resveratrol. Pterostilbene nwere okpukpu anọ karịa ngwa ngwa karịa ka ọ na-esite na mgbari nri na anụ ahụ karịa resveratrol. Na usoro a, nke a nwere ike ịme Pterostilbene dị irè karịa ọtụtụ oge karịa resveratrol. Agbanyeghị, ekwesịrị imekwu ọmụmụ iji kwado nke a.

A na - ejikọtakwa Pterostilbene na resveratrol mgbe ụfọdụ iji nye mgbakwunye na ntinye capsule. A kwenyere na mgbakwunye a ga-enwe ike karịa ka ọ na-agakọ uru nke ihe abụọ ahụ.

5. Ihe mgbakwunye Pterostilbene

Obi abụọ adịghị ya na iji nweta abamuru kachasị dị mma nke Pterostilbene, a na-atụ aro ka ị were ya dị ka mgbakwunye ntụ ntụ. Pterostilbene mmezi na-azụ ahịa n'ọtụtụ ụlọ nri na eke nri na ụlọ ahịa dị n'ịntanetị na-ahụ maka usoro nri. Nwekwara ike ịchọta ndị na-emepụta pterostilbene n'ịntanetị.

Ihe mgbakwunye Pterostilbene dị n'ụdị capsules, yana ọtụtụ usoro onunu ogwu. Shouldkwesịrị ịgụ nke ọma ma ọ bụ akara ahụ ma rịba ama ego ole Pterostilbene dị na capsule nke ọ bụla tupu ịzụta ya. Ihe a di nkpa n’ihi na usoro onunu ogwu di iche iche nwere ike igosiputa ihe di iche.

Ọzọkwa, ụfọdụ usoro pterostilbene nwere ike ịdị elu karịa nke nyochaworo n'ime mmadụ. Usoro onunu a na-enwetakarị n'etiti 50 mg na 1,000 mg na capsule ọ bụla.

Dịka anyị kwuru na mbụ, a na-enweta ọgwụ mgbakwunye, na nchịkọta ndị kachasị ewu ewu bụ Pterostilbene na resveratrol. Pterostilbene jikọtara ya na curcumin, tii akwụkwọ ndụ akwụkwọ ndụ, astragalus, na ihe ndị ọzọ sitere n'okike.

Nwekwara ike ịchọta ude mmanụ anwụ nwere Pterostilbene n'agbanyeghị na nke a adịkarịghị. Egoghi oke Pterostilbene iji chebe gị nke ọma na ọrịa cancer anụ, mana ọ nwere ike inye nchebe ọzọ.

6. Ebee ka ị ga-ahụ Peterostilbene ntụ ntụ kacha mma?

Ọ bụrụ na ị na-achọ pterostilbene ntụ ntụ dị elu maka ọrịre, mgbe ahụ ị nọ ebe kwesịrị ekwesị. Anyị bụ otu n'ime ndị kachasị ewu ewu, ndị nwere mmụta, na ndị na-emepụta pterostilbene na China. Anyị na-enye ngwaahịa dị ọcha ma kwadebere nke ọma nke ndị ụlọ nyocha ụwa niile na-anwale ya mgbe niile iji hụ na ịdị ọcha na nchekwa. Anyị na-enyefe iwu gafee US, Europe, Eshia na akụkụ ndị ọzọ nke ụwa. Yabụ ọ bụrụ na ịchọrọ ịzụta pterostilbene ntụ ntụ nke kachasị mma enwere ike, kpọtụrụ anyị ugbu a.

References

  1. Rimando AM, Kalt W, Magee JB, Dewey J, Ballington JR (2004). "Resveratrol, pterostilbene, na piceatannol na tomato osisi". J Agric Food Chem. 52 (15): 4713–9.
  2. Kapetanovic IM, Muzzio M., Huang Z., Thompson TN, McCormick DL Pharmacokinetics, oa bioavailability, na profaịlụ metabolic nke resveratrol na analog dimpleylether ya, pterostilbene, na oke. Chei. Pharmacol. 2011; 68: 593-601.
  3. Nchekwa nke trans rat resveratrol dị ka nri akwụkwọ na -ebi iwu Regulation (EC) Mba 258/97 ″. EFSA Journal. Ndị na-ahụ maka nchekwa nri nri Europe, kọmiti nke EFSA na nri Dietetic, Nutrition and Allergies. 14 (1): 4368
  4. Becker L, Carré V, Poutaraud A, Merdinoglu D, Chaimbault P (2014). "MALDI mass spectrometry onyonyo maka otu mgbe resveratrol, pterostilbene na viniferins na akwụkwọ mkpụrụ vaịn". Molecules. 2013 (7): 10587–600.

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