spam

Phcoker nwere ikike imepụta oke na inye Spermine n'okpuru ọnọdụ cGMP.

Spermine na polyamines

Yabụ kedu ihe bụ polyamines? Gịnịkwa mere ha ji dị oké mkpa n’ọrụ nke ịka nká? Polyamines dị ebe niile na sel dị ndụ na anụ ahụ. A maara ha dị ka amines biogenic nke bụ ogige nwere ihe karịrị otu amino abụọ. Polyamines na-emekarị na ahụ anyị na ọ dị mwute ikwu, ka anyị na-etolite ọkwa ndị a na-ebelata.

Polyamines na-arụ ọrụ na:
  • Nkewa cell na ọdịiche
  • Mmụba cell
  • DNA na njikọ protein
  • Homeostasis (ikike ahụ iji dozie ma nọgide na-enwe ọnọdụ kwụsiri ike)
  • Na okwu mkpụrụ ndụ ihe nketa (koodu nke mkpụrụ ndụ ihe nketa eji eduzi njikọ protein)


N'ileghachi anya na ọrụ niile nke polyamines, anyị nwere ike ịhụ ihe kpatara anyị ji echegbu onwe anyị ma ọ bụrụ na ịka nká na-eme ka ọkwa anyị daa. Ogige ndị a dị mkpa yiri ka ha na-etinye aka na usoro nke uto cell na ịnọgide na-enwe nkwụsi ike nke mkpụrụ ndụ ihe nketa. Ya mere, ha na-enyere aka belata usoro nke ito eto ma melite ogologo ndụ anyị na ogologo ahụike anyị (ụdị ndụ anyị). Mbelata nke ọkwa polyamines anyị na-agọnahụ anyị ụfọdụ uru ọgwụgwọ bara ụba.

Isi polyamines dị na mkpụrụ ndụ mammalian na ọbụna osisi bụ spermidine, spermine, na putrescine. Ụmụ mmadụ na osisi nwere ọtụtụ ihe jikọrọ ọnụ, otu n'ime ihe ndị ahụ bụ na anyị abụọ na-eme ihe niile anyị nwere ike ime iji hụ na anyị dị ndụ ogologo oge. Otu n'ime ụzọ anyị nwere ike isi nweta nke ahụ bụ site na oriri nke polyamines na polyamine synthesis. Usoro a na-akwalite autophagy, nke bụ usoro ahụ anyị iji dochie sel ndị mebiri emebi na mkpụrụ ndụ ọhụrụ, nke emegharịrị ọhụrụ. Dị ka ị nwere ike iche n'echiche, usoro a nwere ike inyere anyị aka ibi ndụ ogologo, obi ụtọ na ndụ ahụike. Spermine bụ ihe atụ nke polyamine nke nwere ike inye aka kwalite autophagy.

Kedu ihe bụ Spermine?

Spermine bụ polyamine na-emekarị na eukaryotes niile, mana ọ dị ụkọ na prokaryotes. Ọ dị mkpa maka uto cell na ma anụ ahụ nkịtị na neoplastic. A na-etolite spermine site na mgbakwunye nke otu aminopropyl na spermidine site na spermine synthase. Spermine bụ ihe ndabere siri ike na agwa, na na ngwọta mmiri na pH physiological, a ga-ahụ otu amino ya niile dị ka ihe eji eme ihe.

Enwere ike iji spermine n'ụdị ngwa dị iche iche dị ndụ dị ka mgbakwunye ma ọ bụ onye na-achịkwa. Ejiri ya dị ka matrix na DHB maka MALDI-MS nke sialylated glycans na ọnọdụ ion adịghị mma.

Kedu ihe bụ spermine tetrahydrochloride ntụ ntụ?

Spermine tetrahydrochloride bụ polyamine nke na-emepụta mmetụta modulatory dị iche iche na ọwa nnabata NMDA, na-eme site na saịtị akọwapụtara na mgbagwoju anya nke nwere ike ịkpata ma agonist na antagonist. Spermine tetrahydrochloride ntụ ntụ bụ ụdị tetrahydrochloride nke Spermine. Spermine tetrahydrochloride ntụ ntụ bụ ọcha ntụ ntụ mgbe Spermine free base dị n'ụdị mmiri mmiri. Uru Spermine tetrahydrochloride ntụ ntụ bụ otu uru Spermine.

Spermine Mechanism of action: kedu ka o si arụ ọrụ?

A na-enweta spermine site na spermidine site na spermine synthase. Spermine bụ polyamine, obere cations organic nke achọrọ maka uto cell eukaryotic. Spermine, bụ nke a na-ahụkarị na mkpokọta millimolar na nucleus. Spermine na-arụ ọrụ ozugbo dị ka onye na-ekpochapụ radical free, ma na-emepụta ihe dị iche iche nke na-egbochi mmebi oxidative na DNA. Nbibi oxidative nke DNA sitere na ụdị ikuku oxygen na-emeghachi omume bụ nsogbu na-aga n'ihu nke mkpụrụ ndụ ga-echedo ka ọ dịrị ndụ. N'ihi ya, spermine bụ isi ihe intracellular sitere n'okike nke nwere ike ichebe DNA pụọ na mwakpo radical free. Spermine na-etinyekwa aka na nhazi nke okwu mkpụrụ ndụ ihe nketa, nkwụsi ike nke chromatin, na mgbochi nke njedebe DNA na-eme ka endonuclease.

Uru spermine - Kedu ihe a na-eji spermine?

Spermine bụ polyamine endogenous nke nwere ọtụtụ amino dị iche iche. Achọpụtara na ọ na-arụ ọrụ dị mkpa na metabolism cellular na sel eukaryotic niile. Spermine, polyamine na-emekarị, apụtala n'oge na-adịbeghị anya dị ka ihe na-egosi ihe mgbochi ịka nká. Ihe mgbakwunye spermine nke Spermine tetrahydrochloride ntụ ntụ na-eme ka ndụ dịkwuo ogologo na iguzogide nrụgide, ma na-ebelata ihe omume nke ọrịa gbasara afọ na ọnwụ nke ike locomotor.

Spermine emeliorate ebe nchekwa ọnwụ.
Mgbe ọgwụgwọ Spermine gasịrị, ikike nke njide ebe nchekwa na-eme ka ọ dịkwuo mma na ụmụ oke SAMP8. Spermine tetrahydrochloride ntụ ntụ mere ka ọ dịkwuo ogologo oge iji nyochaa ihe ọhụrụ ahụ.

Spermine na-ebelata nrụgide oxidative na ụbụrụ ụmụ oke.
Anyị tụlere mmetụta polyamine na rapamycin na nrụgide oxidative. Spermine belatara ọkwa MDA na ụbụrụ ụmụ oke SAMP8. A na-abawanye ọrụ nke SOD na otu spermine. Nsonaazụ ndị a gosiri na Spermine tetrahydrochloride ntụ ntụ na-eme ka nrụgide oxidative dị ukwuu na SAMP8.

Spermine na-abawanye plasticity synapti na ihe neurotrophic
Achọpụtara okwu nke ihe neurotrophic na protein synapti na otu spermine. Ihe na-eto eto na-eto eto (NGF), ụbụrụ na-enweta ụbụrụ neurotrophic (BDNF), njupụta postsynaptik na njupụta postsynaptic doro anya na ọ dị mma n'ime otu spermine.

Spermine na-edozi nsogbu mitochondrial
N'ihi ya egosipụtara, okwu nke protein ndị metụtara mitochondion ka mma nke ukwuu na spermine otu. O doro anya na Spermine kpalitere phosphorylation nke DRP 1. Ntụle nke ATP dị ala na otu oke oke SAMP8 karịa na otu spermine.

Spermine na-ebute autophagy
Mgbe ọgwụgwọ Spermine tetrahydrochloride ntụ ntụ gasịrị, ọkwa nke phosphorylation nke AMPK dị elu. Ọkwa nke protein ndị metụtara autophagy gụnyere abawanyela nke ukwuu na otu spermine.

Ọkpụkpụ spermine emeliorate apoptosis

Spermine na-ebelata mbufụt
N'ihi na e gosiri, Mgbe ọgwụgwọ nke spermine, okwu nke mkpali na-edozi na-ebelata sharply. Ihe mgbakwunye spermine nke Spermine tetrahydrochloride ntụ ntụ na-eme nwere ike ịkụda mbufụt na ụbụrụ.

Spermine na spermidine

Ọdịnaya nke spermidine na spermine na mkpụrụ ndụ mammalian nwere ọrụ dị mkpa na protein na nucleic acid njikọ na nhazi, nchebe pụọ na mmebi oxidative, ọrụ nke ọwa ion, mmụba cell, ọdịiche, na apoptosis.

Spermine bụ ụdị ọzọ nke polyamine. Ngwakọta abụọ a na-ejikọta ibe ha. A na-enweta Spermine site na Spermidine ma dị mkpa maka metabolism cell na mmadụ na osisi. Inwe ihe mgbakwunye spermidine na-eme ka ị nweta uru spermine kwa.

Ngwa spermine tetrahydrochloride ntụ ntụ

A na-eji Spermine tetrahydrochloride ntụ ntụ mee ka DNA gbasaa maka nyocha cytometric na-asọpụta site na anụ ahụ ara ara kpọnwụrụ akpọnwụ, anụ ahụ nke salivary gland, renal na thyroid tumors2 na mkpụrụ ndụ ọbara uhie nke ọkụkọ. Ugbu a Spermine tetrahydrochloride ntụ ntụ ejirila na mgbakwunye mgbochi ịka nká. Zụrụ Spermine tetrahydrochloride ntụ ntụ n'ịntanetị.

Ebe ị ga-azụta nnukwu Spermine?

N'ime ụwa nke oge a, ị nwere ike ịzụta ihe mgbakwunye Spermine nke Spermine tetrahydrochloride ntụ ntụ mere na ntụsara ahụ nke ụlọ gị n'ịntanetị. Agbanyeghị, ị ga-enyocha ebe niile maka ndị na-eweta Spermine tetrahydrochloride ntụ ntụ dị elu. Nyocha ndị ahịa bụ otu ụzọ iji kwe nkwa uru Spermine tetrahydrochloride ntụ ntụ ma na-anakọta ozi gbasara mmetụta spermine nwere ike ime.

Enwere ọtụtụ spermine tetrahydrochloride ntụ ntụ maka ọrịre n'ahịa. Phcoker dị ka ụlọ ọrụ mmepụta ihe na-enye nnukwu spermine tetrahydrochloride ntụ ntụ. Ihe mgbakwunye spermine kacha mma bụ na ịdị ọcha dị elu na bioavailability. Spermine tetrahydrochloride ntụ ntụ ịzụ ahịa n'ogbe ga-enweta ezigbo ọnụ ahịa.

FAQ

Ọ bụ Spermine Anti ịka nká?
Otu akwụkwọ e bipụtara na 1992 chere na spermine na spermidine na-echebe DNA pụọ na mmebi oxidative free-radical. Ọkwa spermine anyị na-agbada ka anyị na-aka nká, nke na-abụghị ozi ọma nye anyị ka anyị nwere ike tufuo uru mgbochi ịka nká na ahụike. N'otu nnwale, ụmụ oke transgenic na-enweghị ike ịmịpụta spermine na spermidine tụfuru ntutu ha, nweta akpụkpọ ahụ na-adịghị mma, wee nwụọ n'okpuru ụmụ oke nkịtị, ma ọ dịghị ihe ọ bụla pụtara n'ụzọ na-adịghị mma na akụkụ ọ bụla.

spermine ọ bụ antioxidant?
Dị ka ụfọdụ nnyocha si kwuo, nchịkwa spermine nwere ike ime ka ikike antioxidant dị na imeju na splin dịkwuo elu ma nwee ike ịkwalite ọkwa antioxidant na splin na imeju n'okpuru nrụgide oxidative. Achọpụtara spermine dị ka antioxidant dị ike na onye na-egbochi mkpali. Ngwakọta ahụ dị na akụkụ ahụ niile na akụkụ ahụ niile.

Kedu ihe spermine na-eme na sperm?
Ebe ọ bụ na kpọmkwem oge ike ike na mmeghachi omume acrosome dị oke mkpa maka njikọta spam nwoke na nwanyị na-aga nke ọma, a na-atụ aro na ọrụ nke spermine seminal bụ igbochi ikike akaghi aka na mmeghachi omume acrosome.

Ebee ka spermine dị?
Spermine bụ polyamine, obere cations organic nke achọrọ maka uto cell eukaryotic. Spermine, bụ nke a na-ahụkarị na mkpokọta millimolar na nucleus. Spermine na-arụ ọrụ ozugbo dị ka onye na-ekpochapụ radical free, ma na-emepụta ihe dị iche iche nke na-egbochi mmebi oxidative na DNA.

spermine ọ bụ protein?
Ọ bụ ezie na spermidine nwere ọrụ dị mkpa na nke pụrụ iche dị ka onye na-ebute hypusine a mgbanwe ntụgharị post-translational nke elongation factor eIF5A, nke dị mkpa maka protein a na-arụ ọrụ na njikọ protein, ọ dịghị ọrụ pụrụ iche maka spermine achọpụtala n'enweghị mgbagha.

Kedu otu esi echekwa ngwọta spermine?
Na-echekwa na 2-8 Celsius C. Ngwọta nke isi ihe na-enweghị spermine na-agbaze ngwa ngwa. Ngwọta na-akawanye mma ma ọ bụrụ na a kwadebere ya na mmiri na-ekpo ọkụ ma chekwaa ya na aliquots oyi kpọnwụrụ, n'okpuru argon ma ọ bụ nitrogen gas. spermine tetrahydrochloride ntụ ntụ bụ ihe kwụsiri ike n'ụdị ntọala enweghị spam.

Ebee ka spermine si abịa?
Spermine dị n'ọtụtụ ihe dị ndụ gụnyere anụmanụ, osisi, ụfọdụ fungi, ụfọdụ archaea, na ụfọdụ nje bacteria. A na-emepụta ya site na spermine synthase, aminopropyltransferase kpọmkwem kpọmkwem. A na-enweta spermine site na spermidine site na spermine synthase.

Kedu ihe bụ pH nke spermine?
Iji gosi na spermine na-arụ ọrụ n'ụzọ ndụ na pH 7.4, anyị nwalere mmetụta ya na ndị na-anabata glutamate (GluR3).

spam ọ dị mma maka akpụkpọ ahụ?
N'ezie, ọ nweghị ihe ọ bụla sayensị na-egosi na-akwado echiche nke itinye semen na akpụkpọ gị. Ewezuga ime obere ihe iji nyere ọdịdị gị aka, ọ pụkwara ịkpata mmeghachi ahụ nfụkasị ahụ na ọrịa ndị a na-ebute site ná mmekọahụ (STIs).

1.Otu n'ihe a na-ekwu na uru spam na-enweta maka akpụkpọ ihu bụ ọgwụgwọ ihe otutu. A kwenyere na uru sperm maka ịma mma sitere na umi spermine. Spermine bụ ihe sitere na spermidine nke dị n'ime ọbara nwoke, nke a kwenyere na ọ na-arụ ọrụ dị ka onye na-ahụ maka antioxidant na mgbochi mkpali. Na mgbakwunye na sperm nwoke, spermine nwekwara ike ịhụ na mkpụrụ ndụ nke ahụ mmadụ. A kwenyere na Spermine na-agwọ ihe otutu ma na-alụ ọgụ maka ihe otutu.

N'ụzọ dị mwute, ọnweghị nsonaazụ nyocha sayensị nke nwere ike igosi uru spam na-eri maka akpụkpọ ahụ nwere otutu.

2.Claims Uru sperm maka ịma mma bụ igbochi ọdịdị nke ihe ịrịba ama nke ịka nká, dị ka wrinkles ma ọ bụ ezi ahịrị. Ọzọkwa, a na-ekwu uru spam na ihu ụmụ nwanyị na-ebilite n'ihi na spam nwere spermine. A kwenyere na Spermine bụ antioxidant nke nwere ike igbanwe ihe ịrịba ama nke ịka nká, dị ka wrinkles na ahịrị dị mma, na-eme ka akpụkpọ ahụ dị ka nwata. Nnyocha e bipụtara n'akwụkwọ akụkọ bụ́ Nature Cell Biology na-ekwu na spermine na-enwe ike ibelata usoro ịka nká ma e jiri ya gbanye ya ozugbo n'ime mkpụrụ ndụ akpụkpọ ahụ mmadụ.

Otú ọ dị, uru nke sperm maka ihu, nke a na-eji ya eme ihe ozugbo n'elu akpụkpọ ahụ, ka egosipụtabeghị. Ya bụ, uru sperm dị maka ihu ụmụ nwanyị na mgbochi nke ịka nká bụ naanị akụkọ ifo.

Ntughari:

  1. Ting-Ting Xu , Han Li, Zhao Dai, George K. Lau, Ben-Yue Li, Wen-Li Zhu, Xiao-Qi Liu, Hao-Fei Liu, Wei-Wu Cai, Shui-Qing Huang, Qi Wang, Shi -Jie Zhang. "Spermidine na spermine na-egbu oge ịka nká ụbụrụ site n'ịkwalite autophagy na ụmụ oke SAMP8" Ebipụtara: Eprel 8, 2020. https://doi.org/10.18632/aging.103035.
  2. Galluzzi et al (2017) Mgbanwe ọgwụ ọgwụ nke autophagy: ikike ọgwụgwọ na ihe mgbochi na-adịgide adịgide. Nat.Rev.Drug.Discov. PMID: 28529316.
  3. Hasan MM, Skaliky M, Jahan MS, Hossain MN, Anwar Z, Nie ZF, Alabdallah NM, Brestic M, Hejnak V, Fang XW. "Spermine: Ọrụ ya na-apụta n'ịchịkwa nzaghachi nrụgide oké ọkọchị na osisi." Selụ. 2021 Jan 28;10 (2):261 . doi: 10.3390/cells10020261. PMID: 33525668.
  4. Grancara S, Martinis P, Manente S, García-Argáez AN, Tempera G, Bragadin M, Dalla Via L, Agostinelli E, Toninello A. "Bidirectional fluxes nke spermine gafee mitochondrial akpụkpọ ahụ." Amino acid. 2014 Mar; 46 (3): 671-9 . doi: 10.1007/s00726-013-1591-0. Epub 2013 Sep 17. PMID: 24043461.
  5. Tse RT, Wong CY, Chiu PK, Ng CF. "Ọrụ spermine nwere ike ịrụ na ihe mmepụta ya na-eme n'ọrịa ọjọọ mmadụ. Int J Mol Sci. 2022 Jan 23;23(3):1258 . doi: 10.3390/ijms23031258. PMID: 35163181.
  6. Sadeghi-Kaji S, Shareghi B, Saboury AA, Farhadian S. "Spermine dị ka a porcine pancreatic elastase activator: spectroscopic na molecular simulation ọmụmụ." Ụlọ ọrụ J Biomol Struct Dyn. 2020 Jenụwarị; 38 (1): 78-88 . doi: 10.1080/07391102.2019.1568306. Epub 2019 Feb 27. PMID: 30810494