Urolithin ntụ ntụ

Phcoker nwere ikike imepụta ihe na inye urolithin a, urolithin b na Urolithin A 8-Methyl Ether n'okpuru ọnọdụ nke cGMP.

Gịnị bụ Urolithin A?

Urolithin A bụ ihe na-emetụta metabolite site na ngbanwe nke ellagitannins site na nje bacteria. Ọ bụ na klas nke ogige ndị a maara dị ka benzo-coumarins ma ọ bụ dibenzo-α-pyrones. E gosipụtara Urolithin A iji kpalite mitophagy ma melite ahụike anụ ahụ na ụmụ anụmanụ ochie na ụdị ihe atụ nke ịka nká. Ka ọ dị ugbu a, egosila na ọ gafere mgbochi mgbochi ọbara, ọ nwere ike ịnwe nsonaazụ neuroprotective megide Ọrịa Alzheimer.

Urolithin A ntụ ntụ bụ ngwaahịa sitere n'okike na arụ ọrụ antiproliferative na antioxidant. Urolithin A bụ nke metabolism site na polyphenols dị na ụfọdụ mkpụrụ na mkpụrụ osisi, ọkachasị pọmigranet. Nkọwa ya - acid ellagic na ellagitannins - bụ ebe niile na okike, gụnyere osisi ndị na-eri nri, dị ka mkpụrụ pọmigranet, strawberries, raspberries, walnuts, tea na muscat grape, yana ọtụtụ mkpụrụ osisi nke ebe okpomọkụ.

Kemgbe afọ 2000, urolithin A abụrụla ihe ọmụmụ mbido banyere mmetụta ọ ga - enwe na ndụ.

Kedu otu Urolithin A si arụ ọrụ?

Urolithin A bụ urolithin, mmadụ microbial mmadụ metabolite nke dietary ellagic acid derivatives (dị ka ellagic acid). Na eriri afọ metabolism nke nje, ellagitannin na ellagic acid na-eduga ná nhazi urolithins A, B, C na D. N'etiti ha, urolithin A (UA) bụ ihe na-arụsi ọrụ ike ma na-arụ ọrụ nke ọma, nke enwere ike iji dị ka mgbochi dị irè -inflammatory na antioxidant.

Na nyocha ụlọ nyocha, egosila na urolithin A na-ebute mitochondria, nke bụ nhọrọ mgbake nke mitochondria site na autophagy. Autophagy bụ usoro nke iwepu mitochondria nkwarụ mgbe ọnyá ma ọ bụ nrụgide gasịrị, ọ na-arụkwa ọrụ nke ọma n'oge ịka nká. ala na ala. Achọpụtala mmetụta a n'ụdị anụmanụ dị iche iche (mkpụrụ ndụ mammalian, òké na Caenorhabditis elegans).

Otú ọ dị, n'ihi na isi iyi nke ellagitannin dị iche, ngwakọta nke ìgwè nje ọ bụla ga-adịkwa iche iche, ya mere arụmọrụ nke ntụgharị na urolithin A dị nnọọ iche na ụmụ mmadụ, ụfọdụ ndị nwere ike ha enweghị ntụgharị ọ bụla.

Urolithin A uru

Urolithin A (UA) bụ nri sitere n'okike, metabolite sitere na obodo microbial. O nwere uru ahụike dị iche iche, gụnyere ibelata mgbaàmà na-afụ ụfụ, mmetụta mgbochi kansa na igbochi mkpokọta lipid.

Dị ka ọgwụ na-arụ ọrụ nke ọma na nke na-arụ ọrụ nke ọma, urolithin A (UA) nwere ike ịrụ ọrụ dị ka mgbochi mgbochi na antioxidant dị irè. O nwekwara ike ịkpalite phagocytosis mitochondrial na ụmụ anụmanụ meworo agadi na ụdị ihe atụ nke ịka nká ma melite ahụ ike.

Enwere ike iji Urolithin A mee ihe dị ka mgbakwunye?

Na 2018, Nchịkwa nri na ọgwụ ọjọọ nke US wepụtara urolithin A dị ka ihe nchekwa dị na nri ma ọ bụ ngwaahịa mgbakwunye nri, yana ọtụtụ sitere na 250 milligram ruo 1 gram kwa otu.

Enwere mmetụta ọ bụla nke Urolithin A?

Ọmụmụ ihe gbasara nchekwa na ndị okenye egosila na urolithin A na-anabata ya nke ọma. Na vivo ọmụmụ adịghị ekpebi ma enwere nsị ọ bụla ma ọ bụ mmetụta ọjọọ ọ bụla nke nri urolitin A nri.

Ọzọkwa, nchekwa nchekwa oge maka mgbakwunye nke Urolithin A na pọmigranet amaghị, ọ bụ ezie na ọgwụgwọ dị mkpirikpi na wepụ mkpụrụ pọmigranet adịghị mma.

Gịnị bụ Urolithin B? Urolithin B ntụ ntụ?

Urolithin B ntụ ntụ (CAS NO: 1139-83-9) bụ urolithin, ụdị ogige phenolic mepụtara na nsị mmadụ mgbe ịmịkọrọ nri ellagitannins dị ka pọmigranet, strawberries, red raspberries, walnuts or oak-old red wine . Urolithin B dị na mmamịrị n'ụdị urolithin B glucuronide.

Urolithin B na-ebelata mmebi protein ma na-ebute hypertrophy muscle. Urolithin B na-egbochi ọrụ nke aromatase, enzyme nke na-agbanwe estrogen na testosterone.

Urolithin B bụ ihe okike sitere na ọrụ antiproliferative na antioxidant. E gosipụtara Urolithin B ka ọ gafere ihe mgbochi ụbụrụ ọbara, ọ nwere ike ịnwe nsonaazụ neuroprotective megide Ọrịa Alzheimer.

Urolithin B bụ metabolite microbial metabolic nke ellagitannis ma gosipụta ikike mgbochi oxidant na pro-oxidant na-adabere na sistemụ na ọnọdụ. Urolithin B nwekwara ike igosipụta estrogenic na / ma ọ bụ ọrụ mgbochi estrogenic.

Gịnị bụ Urolithin B eji maka? Urolithin B (UB) uru

Uru Urolithin B:

Na-akpali njikọta protein Protein

Na-ebelata Mwepu Mwepụ Akpụkpọ Ahụ

Nwere ike inwe mmetụta na-egbochi uru ahụ

Nwere ike inwe Anti-Aromatase Njirimara

Urolithin B maka oke akwara

Urolithin B nwere ike belata mmebi ahụ na-eme n'oge mmega ahụ siri ike ma chekwaa akwara megide nrụgide nke nri oke abụba na-ebute. Nnyocha nyocha nke Urolithin B na ụmụ oke hụrụ na ọ mere ka uto myotubes tolite na ọdịiche site na ịbawanye uru protein. O gosiputara ikike igbochi ubiquitin – proteasome way (UPP), ihe kachasi eme maka protein catabolism. O butere mgbali umeji akwara na belata atrophy muscle.

Mgbe atụnyere testosterone, Urolithin B mgbe ewere ya na 15 uM mụbara androgen receptor ọrụ site na 90% ebe testosterone bụ naanị ike rụzuo ọrụ nnabata nke 50% na 100uM. Nke a pụtara na ọ ga-ewe obere Urolithin B ka iwelie ọrụ androgen ka ọ dịkwuo irè mgbe ahụ ọnụọgụ dị elu nke testosteronewhich na-abawanye ọrụ androgen.

Ọzọkwa, kacha dị ike 15uM nke Urolithin B buru ibu protein protein muscle site na 96% mgbe e jiri ya tụnyere 100uM nke insulin, nke bụ protein protein akwara dị ukwuu site na 61% kachasị arụ ọrụ. Nkwenye ahụ bụ na ọ ga-ewe Urolithin B ogologo ụzọ dị ukwuu iji mee ka njikọta protein protein dịkwuo elu.

Ọmụmụ ihe ndị a na-egosi na Urolithin B nwere ike igbochi catabolism protein ma n'otu oge na-abawanye njikọta protein, ọ bụ ihe eke sitere n'okike na-enyere aka iru akwara anụ ahụ ma na-egbochi imebi akwara.

Urolithin B bụ otu n'ime gutrobial metabolites nke ellagitannins, ma nwee mgbochi mkpali na antioxidant mmetụta. Urolithin B na-egbochi ọrụ NF-byB site na mbenata phosphorylation na mbibi nke IκBα, ma na-egbochi phosphorylation nke JNK, ERK, na Akt, ma na-eme ka phosphorylation nke AMPK dịkwuo mma. Urolithin B bụkwa onye na-achịkwa akwara ọkpụkpụ.

Kedu ihe bụ Urolithin A 8-Methyl Ether?

Urolithins bụ metabolites nke abụọ nke ellagic acid sitere na ellagitannins. N'ime ụmụ mmadụ, ellagitannins na-agbanwe site na gootu microflora ka ọ bụrụ acid acid nke a na-agbanwewanye ka urolithins A, urolithin B, urolithin C na urolithin D na nnukwu eriri afọ.

Urolithin A 8-Methyl Ether bụ ngwaahịa dị n'etiti n'oge nchịkọta nke Urolithin A. Ọ bụ metabolites dị mkpa nke ellagitannin ma nwee njikwa antioxidant na mgbochi.

Kedu ka Urolithin A 8-Methyl Ether si arụ ọrụ?

(1) Njirimara antioxidant

Urolithin A 8-Methyl Ether nwere mmetụta antioxidant site na mbenata radicals free, ọkachasị mbenata ogo nke ụdị oxygen (ROS) na-arụ ọrụ na sel, na igbochi lipid peroxidation na ụdị sel ụfọdụ.

(2) Njirimara mgbochi mkpali

Urolithin A 8-Methyl Ether nwere ihe ndị na-egbochi mkpali site na igbochi mmepụta nke nitric oxide. Ha na-egbochi kpọmkwem okwu nke inricible nitric oxide synthase (iNOS) protein na mRNA nke na-ebute mbufụt.

Urolithin A 8-Methyl Ether uru

Urolithin A 8-Methyl Ether bụ ngwaahịa dị n'etiti na usoro njikọ nke Urolithin A, na ihe dị mkpa nke abụọ nke ellagitannin, nke nwere antioxidant na mgbochi mkpali. Dị ka metabolite nke Urolithin A, ọ nwekwara ike inwe ụfọdụ uru nke Urolithin A:

(1) Nwere ike ịgbatị ogologo ndụ;
(2) Nyere aka igbochi kansa prostate;
(3) Akpalite mmuta;
(4) Ihe nwere ike ibute ibu ibu

Ojiji nke Urolithin A 8-Methyl Ether Mmeju?

Urolithin A na-ahụ ihe mgbakwunye ngwa ngwa n'ahịa dị ka mgbakwunye mgbakwunye isi nri ellagitannin. Dị ka ngwaahịa metabolic nke Urolithin A, Urolithin A 8-Methyl Ether nwekwara ike iji na mgbakwunye.

Agbanyeghị, enweghi ọtụtụ datas gbasara ozi mgbakwunye ya, ma achọrọ nyocha ọzọ.

Ntughari:

  1. Garcia-Muñoz, Cristina; Ogwu, Fabrice (2014-12-02). "Metabolic Fate nke Ellagitannins: Mmetụta maka Ahụ Ike, na Atụmatụ Nchọpụta Maka Nri Na-arụ Ọrụ Na-agbanwe agbanwe". Nyocha dị oke egwu na Science Science na Nutrition. 54 (12): 1584–1598. ma ọ bụ: 10.1080 / 10408398.2011.644643. ISSN 1040-8398. PMID 24580560. S2CID 5387712.
  2. Ryu, D. et al. Urolithin A na-ebute mitophagy ma na-agbatịkwu afọ na C. elegans ma na-eme ka ahụ ike dị na oke. Nat. Ahụike. 22, 879–888 (2016).
  3. "FDA GRAS mara ọkwa GRN Nke 791: urolithin A". Nchịkwa nri na ọgwụ ọjọọ na US. 20 Disemba 2018. Weghachite 25 August 2020.
  4. Singh, A .; Andreux, P.; Blanco-Bose, W.; Ryu, D.; Aebischer, P.; Auwerx, J.; Rinsch, C. (2017-07-01). "Urolithin A na-eji ọnụ ekwu okwu dị mma ma na-agbanwezi ahụ ike na mitochondrial biomarkers na ndị agadi". Innovation na nká. 1 (suppl_1): 1223–1224.
  5. Heilman, Jacqueline; Andreux, Pénélope; Tran, Nga; Rinsch, Chris; Blanco-Bose, William (2017). "Nnyocha nchekwa nke urolithin A, metabolite nke ụmụ mmadụ na-emepụta site na nri nri nke osisi ellagitannins na ellagic acid." Nri nri na Chemical. 108 (Pt A): 289–297. ma ọ bụ: 10.1016 / j.fct.2017.07.050. PMID 28757461.