L - (+) - Ergothioneine (EGT) (497-30-3)

March 15, 2020
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Ergothioneine bụ amino acid na-ewere ọnọdụ na ọ bụ usoro nke thiourea nke histidine, nke nwere sọlfọ sọlfọ na …… ..


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L - (+) - Ergothioneine (EGT) powder Smmezi

Product Name L - (+) - Ergothioneine (EGT)
Chemical Aha ERGOTHIONEINE;

L-Ergothioneine;

Sym Symothion;

l ergothioneine

Brand Name N / A
Klaasị ọgwụ ọjọọ N / A
CAS Number 497-30-3
InChIKey SSISHJJTAXXQAX-ZETCQYMHSA-N
molekụla Fnhazi C9H15N3O2S
molekụla Wasatọ 229.3 g / mol
Nkịtị Monoisotopic 229.088498 g / mol
esi ebe N / A
Fna-agbanyeghachi Point N / A
Ọkara Ndụ nke Ndụ N / A
Agba White ma ọ bụ na-acha ọcha
Sume Nsogbu na Mmiri (ihe ruru 10 mg / ml)
Sịkwa akwa Tigwe -20 Celsius C
Antinye l ergothioneine ntụ ntụ ejirila na mgbakwunye ahụike

L - (+) - Ergothioneine (EGT) (497-30-3) Isi nyocha

Ergothioneine bụ ihe amino acid na-ewere ọnọdụ na ọ bụ usoro nke thiourea nke histidine, nwere sọlfọ sọlfọ na mgbanaka imidazole. A na-eme ihe owuwu a na obere ihe dị ndụ, ọkachasị Actinobacteria, Cyanobacteria, na ụfọdụ, dịkwa ka usoro ha. Ergothioneine chọrọ onye na-ebugharị ebugharị, EGT, nke a makwaara dị ka OCTN1 (akara akara SLC22A4), iji banye sel. Ekwenyela ngosi EGT n'ahịrị sel mmadụ na nke anụmanụ yana ikike ịrụ ọrụ ergothioneine na vivo.

L-ergothioneine bụ ihe amino acid na-ewere ọnọdụ na ọ bụ usoro thiol / thione sitere na histidine. A na-ahụta L-ergothioneine na nchịkọta kachasị elu na olu na nje na obere nri na nri ndị ọzọ gụnyere akwa, anụ, anụ ezi, anụ ọkụkọ, na ọkụkọ.

N'agbanyeghị ọnụnọ nke L-ergothioneine na nri mmadụ na-eri, a hụrụ ya biosynthesis na nje ụfọdụ na nje.

Gịnị bụ L - (+) - Ergothioneine (EGT) ?

L-Ergothioneine bụ amino acid nke a na-ahụkarị na olu, kamakwa na ndagwurugwu eze, anụ sitere na anụmanụ ndị nwere ahịhịa na ahihia ergothioneine, na nri ndị ọzọ. Amino acid bụ kemịkal ndị bụ ihe mgbochi maka protein. A na-eji Ergothioneine eme ọgwụ.

Ndị mmadụ na-ewere ergothioneine maka mmebi imeju, cataracts, ọrịa Alzheimer, ọrịa shuga, na ọrịa obi.

L - (+) - ERGOTHIO bụ biosynthesized chiral amino-acid antioxidant biosynthesized na ụfọdụ nje na na fungi. Ọ bụ ihe dị mkpa bioactive nke ejiriworo mee ihe dị ka ihe na-akpata radieshọn, ihe nyocha nke ultraviolet ray, onye na-achịkwa mmeghachi omume mmebi ihe na-egbu ihe na cellulite bioloergetics, yana physiological cytoprotector, wdg.

A na-etinye L-Ergothioneine mgbe ụfọdụ na akpụkpọ ahụ iji gbochie wrinkles, belata ihe ịrịba ama nke akpụkpọ nká, ma belata mmebi anyanwụ.

L - (+) - Ergothioneine (EGT) uru

L-ergothioneine bụ ihe pụrụ iche n'ihi na ọ nwere ike iru isi nke mkpụrụ ndụ ụfọdụ dị ka erythrocytes, n'adịghị ka ọgwụ antioxidants ndị ọzọ dị ka vitamin C na E. Ọ nwere n'ezie ihe omumu nke protein protein na - ebu, na-enyere ya aka iwere ya ikike. mkpụrụ ndụ sel. Ya mere, enwere ike intracellular antioxidant, dị ka L-glutathione. Ọzọkwa, egosikwala ya dị ka onye siri ike, na-enyere ya aka ijikọ ọla ndị na-egbu egbu, ma na-echekwa mkpụrụ ndụ ọbara n'ụdị mmebi niile.

N'inwe ume site na njigide antioxidant ya, ndị ọrụ nyocha mechara nyocha nke mmetụta mgbochi ya, ebe ergothioneine na-eme, n'etiti ndị ọzọ, cytokine pro-inflammatory, interleukin. L - (+) - Ergothioneine (EGT) ya mere nwere otutu ihe ndi n’ilegharia anya n’ime ahu mmadu:

  • na-egbochi irighiri oxygen na-emeghachi omume (radicals free), si otú a na - ebuso nrụgide oxidative ọgụ ma belata mbibi nke DNA mitochondrial, oxidation nke protein na Lipoxidation lipid;
  • Chelates - ma ọ bụ ọnya - ọnụnụ dị mma dị mma;
  • Nwere ike rụọ ọrụ enzymes antioxidant dị ka glutathione peroxidase ma ọ bụ SOD, ebe na-egbochi enzymes na-emepụta radieshon superoxide;
  • Na-ebelata nsị nke mmiri dị iche iche dị ka haemoglobin na myoglobin;
  • Na-echebe mitochondria;
  • L-ergothioneineredu mmetụta ọjọọ nke ụzarị UV, dị ka ihe na-echebe maka Nlekọta Azụ.
  • Na-echekwa ma na-ejigide ọkwa nke antioxidants ndị ọzọ dị ka vitamin C na E, glutathione na SOD;
  • Na-echebe ụbụrụ pụọ na neurotoxins ma si otú a na-ekere òkè na mgbochi megide mbelata nke ọgụgụ isi;
  • Na-agba ume iku ume cellular na abụba lipolysis, si otú a na-abawanye ume na ume maka mmega ahụ;
  • Mgbe ejikọtara ya na hyaluronic acid, glucosamine, collagen, egosiri ya ka ọ belata ihe mgbu na nkwonkwo ma nwekwuo nkwonkwo, jikọtara ya na usoro ọrụ posta na-adịghị mma, mgbe naanị izu isii gasịrị.

L - (+) - Ergothioneine (EGT) nchekwa

Ọ bụ ezie na l-ergothioneine nwere aha ma nwee ike isi na ero ergam, ọ bụghị nsi n'ụzọ ọ bụla.

European Union nwere ụkpụrụ mgbakwunye siri ike karịa United States ma kpebisie ike na mmeju l-ergothioneine dị nchebe ma ghara inwe mmetụta ọjọọ na ndị okenye na ụmụaka.

Kọmitii na ngwaahịa nri Dietetic nke European Security Safety Authority na-achọpụta na oke nchekwa kwa ụbọchị nke 2.82 mg / kg nke ahụ mmadụ maka ụmụ ọhụrụ, 3.39 mg / kg maka ụmụaka, yana 1.31 mg / kg maka ndị okenye, gụnyere ụmụ nwanyị dị ime na ụmụ na-enye nwa ara.

L - (+) - Ergothioneine (EGT) ntụ ojiji na ngwa

Agbakwunyere mgbakwunye kwesịrị ekwesị na / ma ọ bụ nri ka mma gụnyere vitamin nke ogologo oge dịka mgbakwunye L-ergothioneine nwere ike belata ọtụtụ ihe ọghọm nke ọrịa na-adịghị ala ala na ịka nká.

L-ergothioneine ntụ ntụ bụ ezigbo ihe dị mma maka usoro ịka nká nke ọma, usoro nri.

Nnyocha na-atụ aro na ọgwụ antioxidant EGT nwere ike ịrụ ọrụ dị ka ihe mgbochi mkpali iji mee ka ichebe mkpụrụ ndụ gharazie ịlụ ọgụ na ọrịa neurodegenerative.

  1. mbufụt

Nnyocha na-egosi na dịka ọgwụ antioxidant, EGT nwere ike ịgbachitere mmerụ ahụ.

Ọrịa ogbu na nkwonkwo bụ ọrịa akpịrị na-arịa oke egwu (yana anaghị enwekarị nkọwa) na-efe efe.

O kwere omume na EGT nwere ike belata mbufụt n’ime ndị ọrịa nwere ọrịa ogbu na nkwonkwo.

  1. Ọrịa Neurodegenerative

Dịka cytoprotectant, EGT bụ mgbakwunye a ma ama n'etiti ndị ọrịa Alzheimer na Parkinson.

EGT na-akwado usoro nchebe nke eke ahụ na-egbochi ahụ gị ma nwee ike ichebe mkpụrụ ndụ ụbụrụ site na mmebi nke oxidative na nrụgide site na radicals n'efu.

Site na ichebe mkpụrụ ndụ ụbụrụ, ihe eji eme ya iji gbochie ọnwụ mkpụrụ ndụ ụbụrụ na ebe mbụ ma chebe ya megide ọrịa neurodegenerative.

  1. Ọrịa Umeji

N'ihi cytoprotectant ya na ọgwụ nwere ike ịlụ ọgụ, EGT bụ amino acid kachasị amasị ndị ọrịa nwere ọrịa imeju.

  1. Ihe ential Ga-emegide -ka Ya

Often ga-ahụ EGT ọtụtụ na ngwaahịa fatịlaịza n'ihi ngwa cytoprotectant ya na antioxidant- nke nwere ike ichebe akwara akpụkpọ ahụ na mmebi nke oxidative.

Mmebi ahụ dị njọ na nrụgide oxidative bụ ndị kacha akpata enyemaka oge ịka nká, akpụkpọ ahụ na-egbu egbu, na wrinkles.

  1. Ọrịa Lung

Oflọ ọrụ na-ahụ maka nchekwa na United States nyere ndị na-eme nchọpụta na Mahadum Colorado onyinye $ 1.34 iji mụọ usoro ọgwụ antioxidant nke EGT maka ịlụ ọgụ ọrịa ọrịa nku na ọgụ ndị agha.

Reference:

  • Oumari M, et al. Ntughari nke ergothioneine mgbe emeghachiri ya na Singlet oxygen. Radic Biol Med. 2019 Apr; 134: 498-504.
  • Cheah, LK, Halliwell, B. Ergothioneine; ikike antioxidant, arụ ọrụ na ọrụ na ọrịa, Biochim. Biophys. Acta 2012; (5): 784-793.
  • Genghof, DS Biosynthesis nke Ergothioneine na Hercynine site na. Fungi na Actinomycetales, J. Bacteriol., 1970; 103 (2): 475–478.
  • Refine, JE, Elkins, ND Mmetụta ergothioneine na oke mmerụ ahụ na oke ọnya na oke oke ikuku cytokine, Prev. Ọrịa. 2012; (54): S79-S82.
  • Ogwe EFSA na Ngwa nri Dietetic, Nutrition and Allergies (2017). "Nkwupụta banyere nchekwa nke l-ergothioneine sịntetik dị ka nri akwụkwọ akụkọ - mgbakwunye nri nri na nyocha nchekwa maka ụmụ aka na ụmụaka, ụmụ nwanyị dị ime na ndị na-enye nwa ara". EFSA Journal. 15 (11): 5060. doi: 10.2903 / j.efsa.2017.5060.

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