Pyrroloquinoline Quinone (PQQ) (72909-34-3)

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Pyrroloquinoline quinone (PQQ) (72909-34-3) Nkọwapụta

Gịnị bụ Pyrroloquinoline quinone(PQQ)?

Pyrroloquinoline quinone (PQQ), nke a na-akpọkwa methoxatin, bụ redox cofactor. Achọtara ya na ala na nri dịka kiwifruit, yana mmiri ara ụmụ mmadụ. Pyrroloquinoline quinone bụ pyrroloquinoline nke nwere otu oxo dị na ọnọdụ anọ na-anọ na ise na ụgbọ ndị nọ n'ọkwa 4, 5- na 2. O nwere ọrụ dị ka vitamin na-mmiri mmiri na onye na-eme ka ihe na-aga n'ihu. Na, ọ bụ ihe na - egosi gị maka ọdịmma nke protin ndị metụtara ihe dị iche na sel sel mammalian. Ike imegharịgharị ihe dị elu nke PQQ nwere ike inye ya ọrụ ọgwụ iji kpuchido neurodegeneration na kansa. (Dịka onye nnọchi anya redox, Pyrroloquinoline quinone kwụsiri ike ma nwee ike itinye aka n'ọtụtụ narị mmeghachi omume karịa antioxidants ndị ọzọ, dị ka ascorbic acid, quercetin, na epicatechin.

Pyrroloquinoline quinone bụ biofactor, ma amara ya dị ka enzyme cofactor na nje bacteria. Nchọpụta e mere gosiri na quinone Pyrroloquinoline nwere ike ịnọ n'oge ọmụmụ ọmụmụ mmalite na mmalite. Dị ka ihe ọkụkụ nwere ike itolite, ọ na-abawanye na uto nke anụmanụ na ụmụ mmadụ. A kọwo quinone Pyrroloquinoline isonye na ọtụtụ arụ ọrụ ndu yana uru ọghọm dị na ya (dịka ọmụmaatụ etolite etolite na ezi omumu) na anumanu.

Ọzọkwa, Pyrroloquinoline quinone nwere antioxidant na ọrụ vitamin-like, nke nwere ọtụtụ uru maka ụbụrụ na ahụ. Ọ na-akwalite ahụike na ncheta site na ịlụso mwechondrial dysfunction ma chekwaa neurons mmebi nke oxidative. Ọmụmụ nyocha ahụike n’ime ụmụ mmadụ egosila na Quirroloquinoline quinone na-eme ka ebe nchekwa na nlebara anya dị mkpirikpi, na-eme ka metabolism ike na ịka nká dị mma, ma na-ebelata akara nke mbufụt, yana imeziwanye mmetụta nke ọdịmma.

Olee otu esi eme Pyrroloquinoline quinone(PQQ) ọrụ?

Ihe omumu ihe omimi gosiri gosiputara ikike di egwu maka quinone Pyrroloquinoline na mkpali mitochondrial biogenesis. Rat hepatocytes agbakwunyere na PQQ na 10-30 μM maka 24–48 h gosipụtara “ụba citrate synthase na cytochrome c oxidase, Mitotracker staining, ọdịnaya DNA nke mitochondrial, na iku ume ikuku oxygen. Ntinye nke usoro a sitere na mmụba nke protein nzigide njikọta cAMP (CREB) na peroxisome proliferator-activates na-anabata nnabata-γ coactivator-1α (PGC-1α), ụzọ a mara iji mezie biogenesis mitochondrial. ” Na ọmụmụ vivo na oke na-egosipụtakwa uru bara uru site na mgbakwunye nri na PQQ (2mg PQQ / kg nke nri). Ihe ndị a gụnyere mbelata plasma triglycerides, mmefu ume ọkụ na-abawanye (ya na ọdịnaya hepatic mitochondrial na-arụkọ ọrụ), na ntachi obi dị mma maka ischemia / reperfusion cardia. Ihe atụ nke ọnya na ọnya azụ na-egosi na Pyrroloquinoline quinone attenuates ọnwụ mkpụrụ ndụ neuronal, na akụkụ site na Pyrroloquinoline quinone na-echebe ndị na-anabata N-methyl-d-aspartic acid (NMDA). Atdị ụdị ọrịa oria na-egosi na Pyrroloquinoline quinone supplementation na-ebelata ọnwụ nke neuronal, na-eme ka mkpụrụ ndụ oxygen na-arụ ọrụ na-eme ka ikike na-aga n'ihu, ma na-enyekwa ikike ahụ site na usoro ndị ọzọ.

Uru nke Pyrroloquinoline quinone(PQQ) uru

N'ime ụbụrụ na ahụ, PQQ nwere ọtụtụ uru dị na ya.

- PQQ na-akwado ezigbo ọrụ mitochondrial

Mitochondria bụ ndị na - emepụta ike na sel anyị, ha na - arụkwa ọrụ dị mkpa na ahụike anyị n'ozuzu ya. PQQ site na ichebe mitochondria dị adị ma na-akwalite ọgbọ mitochondrial, yabụ mepụta ATP (Energy). More mitochondria arụmọrụ, ike karịa.

- PQQ na-akwado ihe gbasara akwara

PQQ na-akpali mmepụta nke Nerve Growth Factor (NGF.), Na-echekwa ma na-eweghachi ụbụrụ ụbụrụ na akwara ndị mebiri emebi, yabụ na-egbochi mbelata (ncheta ihe, isi ike mmụta, wdg) n'ihi afọ, ọrịa strok ma ọ bụ nsogbu akwara neurodegenerative, ma na-akwalite mgbochi na antioxidant ịrụ ọrụ, yana nchedo site na akuko gbasara ọrịa obi.

- PQQ na - egbochi nrụgide oxidative

PQQ na-enye nchebe nchebe dị egwu, na-echebe mkpụrụ ndụ n’ime ahụ pụọ na mmebi nke oxidative ma na-egbu ndị na-adịghị mma. Ọ na-akwado metabolism nke ume na ịka nká, ma na-atụle akwụkwọ mmezu ihe eji arụ ọrụ antioxidant na B vitamin.

Na mgbakwunye, PQQ nwekwara ike igbochi ma gwọọ mmebi imeju yana ọrụ anticancer siri ike.

Ngwa eji Pyrroloquinoline quinone(PQQ)

N'ime ọmụmụ 2009 e bipụtara na akwụkwọ akụkọ ahụike ọgwụ, Pyrroloquinoline Quinone gosipụtara na o nwere ikike inye aka ichedo. A ga-eji ya na-agwọta ọdịda ọgụgụ isi (enweghị ebe nchekwa, ihe isi ike mmụta, wdg) n'ihi afọ, ọrịa strok ma ọ bụ nkwarụ neurodegenerative, yana nchebe pụọ na ihe omume obi na akwara ozi. A kọputara nsonaazụ yiri nke a na nnyocha nyocha nke 2011 nke enyere Pyrroloquinoline Quinone ozugbo ka ọ bụrụ mmezi nri, dị ka ihe ọ replacementụ mealụ nri mmiri ara ehi.

Etu esi ezu iru Pyrroloquinoline quinone(PQQ)?

Na ndụ, inwere ike ị nweta PQQ site na ụfọdụ nri iri nri, ọ bụ nke dị na ya n'ọtụtụ nri na ọ drinksụ drinksụ, tinyere ose, pasili, tii ma ọ bụ kiwifruit wdg. Ma, ọ bụrụ na gụọ ọnụọgụ nri mmadụ na-eri kwa ụbọchị, ọtụtụ nke anyị enweghi ike inweta PQQ zuru ezu site na nri ụbọchị anyị. Yabụ, ọ bụrụ na ịchọrọ karịa uru ka ukwuu, ị nwere ike nweta PQQ karịa site n'ụzọ ndị ọzọ, dị ka mgbakwunye nri nri PQQ.

Ntughari:

• Drain, Kelsey (12 February 2017). “Antioxidant E Nwere Ike Nwere Ike igbochi Ọrịa Imeju”. msn.com. Eweghachitere 14 February 2017.
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• Felton LM, Anthony C (2005). "Ihe omumu ihe banyere ndu: oru nke PQQ dika enzyme comactor mammalian?". Nature. 433 (7025): E10, mkparịta ụka E11-2. doi: 10.1038 / nature03322. PMID 15689995.
• Westerling J, Frank J, Duine JA (1979). "Hetictọ methanol dehydrogenase sitere na Hyphomicrobium X: ihe ngosipụta resonance ihe nrịba ama maka usoro Quinone". Biochem Biophys Res Commun. 87 (3): 719–24. doi: 10.1016 / 0006-291X (79) 92018-7. PMID 222269.
• Matsutani M, Yakushi T. Pyrroloquinoline quenone-based dehydrogenases nke nje acetic acid.Appl Microbiol Biotechnol. 2018 Nọvemba; 102 (22): 9531-9540. doi: 10.1007 / s00253-018-9360-3. Epub 2018 Sep 15. PMID: 30218379.