N-Acetyl-L-cysteine ethyl ester (NACET) (59587-09-6) video
NACET (59587-09-6) Nkọwapụta
Product Name | NACET (59587-09-6) |
Chemical Aha | R) -ethyl 2-acetamido-3-mercaptopropanoate; L-Cysteine, N-acetyl-, etyl ester; N-ACETYL-L-CYSTEINE ETHYL ESTER; ethyl (2R) -2-acetamido-3-sulfanylpropanoate; L-Cysteine, N-acetyl-, ethyl ester; N-Acetylcysteine ethylester; |
CAS Number | 59587-09-6 |
InChIKey | MSMRAGNKRYVTCX-LURJTMIESA-N |
Obere | CCOC (= O) C (CS) NC (= O) C |
molekụla Formula | C7H13NO3S |
molekụla arọ | 191.25 |
Nkịtị Monoisotopic | 191.061614 g / mol |
Melting Point | 44.1-44.5 ° C |
Esi mmiri | 337.6 ± 32.0 Celsius C (Eburu amụma) |
njupụta | 1.138 ± 0.06 g / cm3 (Eburu amụma) |
Agba | Nchapụ ọcha |
ngwa | Enwere ike iji Nootropics na ọgwụ maara ihe mee ihe maka ịkwalite ebe nchekwa, itinye uche, okike, ọgụgụ isi na mkpali. A nwekwara ike iji ya mee ka mgbakwunye nri. |
Gịnị bụ NACET(N-Acetylcysteine ethyl ester)?
NACET (N-Acetylcysteine ethyl ester) bu ihe omuma akwukwo lipophilic cell-permeable cysteine nke nwere ihe omuma ogwu puru iche na ikike puru iche nke antioxidant. NACET nwere nnukwu ọnụ bioavailability. Ọ bụ ike antioxidant na ọgaranya precursor nke GSH, nke metụtara free acid N-acetyl -L dị iche na -cysteine (NAC). NACET bụ ntụ na-acha ọcha na ụlọ okpomọkụ ma na-agbaze mmiri na mmiri na ihe ndị na-edozi ahụ.
NAC sitere na cysteine. Kemgbe afọ 1970, a na-eji ya agwọ ndị ọrịa nwere ọgwụ mgbochi acetaminophen na nsogbu akwara, wee zụọ ahịa dịka ọgwụ na ntinye nri. N'iji ya tụnyere NAC, NACET nwere ikike dị elu na akụrụngwa ọgwụ. O nwere ikike iji dochie NAC pharmacological, dị ka onye na-ahụ maka mucolytic, antioxidant, onye na-eweta GSH, paracetamol antidote, na opekata mpe Donor nke na-ebugharị gaseous H 2 S na onye na-ahụ maka nchebe UV.
Na mgbakwunye, egosiputa ikike ike na NACET nwere ike na sel sel ọbara. Achọpụtala na ọ na-agbakọta na mkpụrụ ndụ ọbara uhie nke mmadụ, na-eguzogide n'ụzọ dị irè na mbibi oxidative kpatara hydroperoxides. Ya mere, ikike nke NACET dị ka antioxidant na-emetụta nitrite dị ukwuu karịa nke NAC methemoglobinemia na ọgwụ ndị ọzọ siri ike. Ihe omumu banyere oke achoputala na NACET na etinye uche nke oma karia NAC mgbe ana eji NACET eme onu. Ọ nwere ike ịbanye sel ma mepụta NAC na cysteine, nke na - eme ka hydrogen sulfide (H (2) S) dị na mgbasa. Ọ bụ ezigbo nwa akwukwo maka iji ọnụ mee ihe dị ka onye nrụpụta H (2) S,
Uru NACET (N-Acetylcysteine ethyl ester)
Dịka ọgwụ antioxidant nwere ikike, NACET nwere nnukwu uru na ahụike mmadụ.
- Meziwanye otutu ọnọdụ ahụike ma belata mgbaàmà nke ọrịa ọgụgụ isi;
- Ọgwụgwọ nke overdoses acetaminophen, nchebe nke akụrụ na imeju;
- Meziwanye akpa ume ọrụ site na mbenata mbufụt na imebi imi, si otú ahụ na-ebelata ọrịa na-adịghị ala ala.
- Na-akwalite ahụike ụbụrụ site na ịhazi glutamate na ịgbakwunye glutathione, enwere ike iji gwọọ ọrịa dịka ọrịa Alzheimer na ọrịa Parkinson;
- Meziwanye ọmụmụ ụmụ nwoke na ụmụ nwanyị
- Enwere ike melite ọrụ mgbochi n'ọtụtụ ọrịa, gbochie mmebi nke oxyidative na obi, ma belata ihe ize ndụ nke ọrịa obi.
- Nwere ike mee ka shuga shuga na-eme ka ọ ghara imebi site na Mbelata mbufụt na sel abụba
Ntinye aka nke NAVE (N-Acetylcysteine ethyl ester)
Ebe ọ bụ na NACET gosipụtara mmetụta dị ukwuu na ọrịa ọgụgụ isi, ọrịa iku ume na-adịghị ala ala na ọrịa ọgụgụ isi, a na-ejikarị ya dị ka ọgwụ na mgbakwunye nri iji kpuchido ụbụrụ, melite arụmọrụ nke uche na nke anụ ahụ, iji bulie ncheta, cognition na arụmọrụ egwuregwu
Ntughari:
- Giustarini D, Milzani A, Dalle-Donne I, Tsikas D, Rossi R. N-Acetylcysteine ethyl ester (NACET): akwụkwọ ndụ cysteine cysteine na-adịghị ahụkebe nwere njirimara ọgwụ na-adịghị ahụkebe na ike antioxidant pụrụ iche. Pharmacol Biochem. 2012 Dec 1; 84 (11): 1522-33. doi: 10.1016 / j.bcp.2012.09.010. Epub 2012 Sep 20. PMID: 23000913.
- S-Nitroso-N-acetyl-L-cysteine ethyl ester (SNACET) na N-acetyl-L-cysteine ethyl ester (NACET) -Cysteine ndị na-achọ ọgwụ ọgwụ nwere profaịlụ ọgwụ ọgwụ pụrụ iche maka iji ọnụ mee dị ka OWO, H2S na GSH ndị na-eweta ya na dị ka antioxidants: Nsonaazụ na nyocha. 2018 Feb; 8 (1): 1-9. doi: 10.1016 / j.jpha.2017.12.003. Epub 2017 Dec 13. Nyocha. PMID: 29568662
- N-acetylcysteine ethyl ester dị ka onye nkwalite GSH na mkpụrụ ndụ endothelial bụ isi: Nnyocha ọmụmụ na ọgwụ ndị ọzọ. 2018 Ọkt; 126: 202-209. doi: 10.1016 / j.freeradbiomed.2018.08.013. Epub 2018 Aug 14. PMID: 30114478.
- DimitriosTsikasa, Kathrin S.Schwedhelma, Andrzej Surdackib, Daniela Giustarinic, Ranieri Rossid, Lea Kukoc-Modune, George Kediaf, Stefan Ückertf. S-Nitroso-N-acetyl-L-cysteine ethyl ester (SNACET) na N-acetyl-L-cysteine ethyl ester (NACET) –Abụ ndị na-achọ ọgwụ ọgwụ nwere profaịlụ ọgwụ ọgwụ pụrụ iche maka iji ọnụ mee ka Ọ B NOGH,, H2S na GSH ndị na-eweta ya na dị ka antioxidants: Nsonaazụ na nyocha. Journal of Pharmaceutical Analysis. Mpịakọta nke 8, Isi nke 1, Febụwarị 2018, peeji nke 1-9.