N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6)

Description

NACET (59587-09-6) Nkọwapụta

Gịnị bụ NACET(N-Acetylcysteine ​​ethyl ester)?

NACET (N-Acetylcysteine ​​ethyl ester) bu ihe eji nweta cysteine ​​cysteine ​​nke ohuru nke paceine nke pacaline ya na ogwu ihe puru iche. NACET nwere otutu ihe eji enye ya ahihia. Ọ bụ antioxidant siri ike na ihe ndozi nke GSH, nke metụtara ya acid N-acetyl -L na-akwụghị ụgwọ dị iche na -cysteine ​​(NAC). NACET bụ ihe ntụ ọcha na-acha ọcha n'ime ụlọ ebe a na-agwakọta ya na mmiri na ihe mgbaze mmiri.

NAC sitere na cysteine. Kemgbe afọ 1970, a na-eji ya agwọ ndị ọrịa nwere ọgwụ mgbochi acetaminophen na nsogbu akwara, wee zụọ ahịa dịka ọgwụ na ntinye nri. N'iji ya tụnyere NAC, NACET nwere ikike dị elu na akụrụngwa ọgwụ. O nwere ikike iji dochie NAC pharmacological, dị ka onye na-ahụ maka mucolytic, antioxidant, onye na-eweta GSH, paracetamol antidote, na opekata mpe Donor nke na-ebugharị gaseous H 2 S na onye na-ahụ maka nchebe UV.

Na mgbakwunye, ekwesi ike na nbelata ike nke NACET egosipụtabeghị na sel ọbara ọbara. Achọpụtala ya na-agbakọba na mkpụrụ ndụ ọbara uhie mmadụ, na-eguzogide n'ụzọ dị irè mbibi nke hydroperoxides. Ya mere, ikike NACET dị ka ọgwụ mgbochi nitrit na-akpata nke ukwuu karịrị nke nke NAC methemoglobinemia na ehi ndị ọzọ siri ike. Nchoputa emere n’aputa achoputala na enwere NACET ngwa ngwa karia NAC mgbe ekwuru ya NACET. Ọ nwere ike ịbanye na mkpụrụ ndụ ma mepụta NAC na cysteine, nke na-abawanye hydrogen sulfide (H (2) S) na mgbasa. Ọ bụ ezigbo nwa akwụkwọ maka ọnụ dị ka onye na-emepụta H (2) S,

Uru NACET (N-Acetylcysteine ​​ethyl ester)

Dịka ọgwụ antioxidant nwere ikike, NACET nwere nnukwu uru na ahụike mmadụ.

- Meziwanye otutu onodu ahu ike ma belata akara nke oria;

- Ọgwụ nke acetaminophen overdoses, nchedo akụrụ na imeju;

- Ọ na - eme ka ọrụ ngụgụ dị mma site na ibelata mbufụt na ịkụda imi, si otú ahụ belata ọrịa iku ume na-adịghị ala ala.

- Kwalite ahụike ụbụrụ site na ịhazi glutamate na ịgbakwunye glutathione, enwere ike iji gwọọ ọrịa dịka ọrịa Alzheimer na ọrịa Parkinson;

- Meziwanye ọmụmụ na ụmụ nwoke na ụmụ nwanyị

- Enwere ike melite ọrụ mgbochi ọrịa n'ọtụtụ ọrịa, gbochie mmebi nke oxidative n'obi, ma belata ihe ize ndụ nke ọrịa obi.

- Mee Ka Ike Gbanwee Obara Obara Site na Ibelata oria nke diri

Ntinye aka nke NAVE (N-Acetylcysteine ​​ethyl ester)

N'ihi na NACET gosipụtara nnukwu mmetụta na ọrịa uche, ọrịa iku ume na ọrịa ụbụrụ, a na-ejikarị ya dịka ọgwụ na mgbakwunye nri iji chebe ụbụrụ, melite arụmọrụ na anụ ahụ, iji wee bulie ebe nchekwa, cognition na arụmọrụ egwuregwu.

Ntughari:

• Giustarini D, Milzani A, Dalle-Donne I, Tsikas D, Rossi R. N-Acetylcysteine ​​ethyl ester (NACET): akwụkwọ ndụ cysteine ​​cysteine ​​na-adịghị ahụkebe nwere njirimara ọgwụ na-adịghị ahụkebe na ike antioxidant pụrụ iche. Pharmacol Biochem. 2012 Dec 1; 84 (11): 1522-33. doi: 10.1016 / j.bcp.2012.09.010. Epub 2012 Sep 20. PMID: 23000913.
• S-Nitroso-N-acetyl-L-cysteine ​​ethyl ester (SNACET) na N-acetyl-L-cysteine ​​ethyl ester (NACET) -Cysteine ​​ndị na-achọ ọgwụ ọgwụ nwere profaịlụ ọgwụ ọgwụ pụrụ iche maka iji ọnụ mee dị ka OWO, H2S na GSH ndị na-eweta ya na dị ka antioxidants: Nsonaazụ na nyocha. 2018 Feb; 8 (1): 1-9. doi: 10.1016 / j.jpha.2017.12.003. Epub 2017 Dec 13. Nyocha. PMID: 29568662
• N-acetylcysteine ​​ethyl ester dị ka onye nkwalite GSH na mkpụrụ ndụ endothelial bụ isi: Nnyocha ọmụmụ na ọgwụ ndị ọzọ. 2018 Ọkt; 126: 202-209. doi: 10.1016 / j.freeradbiomed.2018.08.013. Epub 2018 Aug 14. PMID: 30114478.
• DimitriosTsikasa, Kathrin S.Schwedhelma, Andrzej Surdackib, Daniela Giustarinic, Ranieri Rossid, Lea Kukoc-Modune, George Kediaf, Stefan Ückertf. S-Nitroso-N-acetyl-L-cysteine ​​ethyl ester (SNACET) na N-acetyl-L-cysteine ​​ethyl ester (NACET) –Abụ ndị na-achọ ọgwụ ọgwụ nwere profaịlụ ọgwụ ọgwụ pụrụ iche maka iji ọnụ mee ka Ọ B NOGH,, H2S na GSH ndị na-eweta ya na dị ka antioxidants: Nsonaazụ na nyocha. Journal of Pharmaceutical Analysis. Mpịakọta nke 8, Isi nke 1, Febụwarị 2018, peeji nke 1-9.