NADP nnweta nnu (24292-60-2)

March 15, 2020

Nicotinamide adenine dinucleotide phosphate (NADP +) bụ cofactor ejiri na mmeghachi omume anabolic. en-Nicotinamide adenine ……

 


ọnọdụ: Na Production Production
Otu: 25kg / Drum

 

NADP nnweta nnu (24292-60-2) vidiyo

-Nicotinamide adenine dinucleotide phosphate ọgwụ disodium nnu (NADP disodium salt) Smmezi

Product Name -Nicotinamide adenine dinucleotide phosphate phodiet nnu nnu (NADP disodium salt)
Chemical Aha NADP Disodium; Nadide phosphate disodium; NADP; β-NADP; Triphosphopyridine nucleotide disodium nnu;
CAS Number 24292-60-2
InChIKey UNRRSQIQTVFDLS-WUEGHLCSSA-L
Obere C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)OP(=O)([O-])[O-])O)O)O)C(=O)N.[Na+].[Na+]
molekụla Formula C21H26N7Na2O17P3
molekụla arọ 787.37
Nkịtị Monoisotopic 787.039342 g / mol
Melting Point 175-178 ° C
Agba Yellow
Soke iwe -20 Celsius C
mmiri  Solubility > 50 g / L.
ngwa Coenzyme na aerobic na anaerobic oxidations

 

Gini bu β-Nicotinamide adenine dinucleotide phosphate disodium salt (NADP disodium salt)?

Nicotinamide adenine dinucleotide phosphate (NADP +) bụ cofactor ejiri na mmeghachi omume anabolic. β-Nicotinamide adenine dinucleotide phosphate benedium nnu bụ nnu nnu nke NADP +, ọ bụ coenzyme dị mkpa maka ị ferụ mmanya na-egbu egbu nke glucose na oxidative dehydrogenation nke ihe ndị ọzọ. Ọ na-erukwa n'ọtụtụ ebe na anụ ahụ dị ndụ, ọkachasị n'ime imeju.

Nicotinamide adenine dinucleotide phosphate (NADP) na NADPH na-etolite redox. NADPH / NADP ruru na-achịkwa ikike redox intracellular, ọkachasị nzaghachi anaerobic, si otú a na-emetụta nzaghachi metabolic na ahụ. Ihe omuma atu bu mmanu ogwu. NADP bụkwa coenzyme ụzọ dị iche iche na sistemụ cytochrome P450 na sistemụ oxidase / reductase dịka usoro thioredoxin reductase / thioredoxin.

NADPH na -ebelata nha nha maka mmeghachi omume biosynthetic ma na-enye nsonaazụ redox iji gbochie nsị nke ụdị oxygen na-emeghachi omume (ROS), si otú ahụ na-eweghachi glutathione (GSH). Ejikwa ya n’okporo ụzọ anabolic dịka cholesterol synthesis na faty acids Chain ịgbatị.

Na mgbakwunye, sistemụ NADPH na-ahụ maka ịmepụta radicals n'efu na mkpụrụ ndụ mgbochi site na NADPH oxidase. A na-eji radicals ndị a na-akwụghị ụgwọ iji bibie nje na usoro akpọrọ iku ume. Ọ bụ nbilata nke aromatics cytochrome P450 hydroxylated aromatik, steroid, mmanya na ọgwụ.

 

ngwa nke β-Nicotinamide adenine dinucleotide phosphate ọgwụ disodium

Nicotinamide adenine dinucleotide phosphate (NADP) na NADPH na-etolite redox. NADP / NADPH bụ coenzyme nke na-akwado mmeghachi omume redox site na mbufe elektrọn n'ọtụtụ ngwa, ọkachasị mmeghachi omume anaerobic dịka lipid na njikọta akonikal acid. NADP / NADPH bụ di na nwunye coenzyme dị iche iche na sistemụ cytochrome P450 na sistemụ oxidase / reductase, dịka usoro thioredoxin reductase / thioredoxin.

Enzymes ndị ọzọ na-eji NADP eme ihe dị ka coenzyme bụ: Alcohol dehydrogenase: NADP dabere; Aromatic ADH: NADP dabere; Ferredoxin-NADP reductase; L-Fucose dehydrogenase; Gabase; Galafeose-1-phosphate uridyl transferase; Glucose deshydrogenase; L-Glutamic dehydrogenase; Glycerol dehydrogenase: NADP akọwapụtara; Isocitric dehydrogenase; Enzymes malic; 5,10-Methylenetetrahydrofolate dehydrogenase; 6-Phosphogluconate dehydrogenase na Succinic semialdehyde dehydrogenase.

 

Ntughari:

  • Hashida SN, Kawai-Yamada M. Inter-Organelle NAD Metabolism Na-akpali Ihu Ìhè NADP na Osisi. N'ihu osisi. 2019 Jul 26; 10: 960. doi: 10.3389 / fpls.2019.00960. eCollection 2019. PMID: 31404160. PMCID: PMC6676473.
  • Tak U, Vlach J, Garza-Garcia A, William D, Danilchanka O, de Carvalho LPS, Saad JS, Niederweis M. togba nsị nke ụkwara nta bụ NAD + na NADP + glycohydrolase nwere ụdị enzymatic dị iche.J Biol Chem. 2019 Mar 1; 294 (9): 3024-3036. doi: 10.1074 / jbc.RA118.005832. Epub 2018 Dec 28. PMID: 30593509. PMCID: PMC6398120.
  • Liang J, Huang H, Wang S. Nkesa, Mbupute, alyrụ ọrụ Catalytic Mechanism, na Ọrụ Na-arụ ọrụ nke Flavin-based Electron-Bifurcating NADH-Depensive Ferredoxin: NADP + Oxidoreductase. Microbiol ihu. 2019 Mar 1; 10: 373. doi: 10.3389 / fmicb.2019.00373. eCollection 2019. PMID: 30881354. PMCID: PMC6405883.
  • Kawai S, Murata K. "Nhazi na ọrụ nke NAD kinase na NADP phosphatase: enzymes dị mkpa nke na-achịkwa intracellular balance of NAD (H) na NADP (H)". Bioscience, Biotechnology, na Biochemistry. 72 (4): 919–30. ma ọ bụ: 10.1271 / bbb.70738. PMID 18391451.
  • Hanukoglu I. "Nchekwa nke Enzyme-Coenzyme Interfaces na FAD na NADP Binding Adrenodoxin Reductase-A Ubiquitous Enzyme". Akwụkwọ nke Molecular Evolution. 85 (5–6): 205–218. Bibcode: 2017JMolE..85..205H. ma ọ bụ: 10.1007 / s00239-017-9821-9.PMID 29177972.