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Oleoylethanolamide (OEA) (111-58-0)

Oleoylethanolamide (OEA) bụ ihe ngwụcha agbụrụ nke peroxisome proliferator nke na - arụ ọrụ. Ọ bụ …… ..


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Description

Nkọwa Oleoylethanolamide (OEA) (111-58-0)

Product Name Oleoylethanolamide (OEA)
Chemical Aha n-oleoylethanolamine; N- (2-Hydroxyethyl) oleamide; Oleylethanolamide;

N-oleoyl ethanolamine; Oleamide MEA; Oleoyl monoethanolamide;

Oleoyl Ethanolamide;

CAS Number 111-58-0
InChIKey BOWVQLFMWHZBEF-KTKRTIGZSA-N
Obere CCCCCCCCC = CCCCCCCCC (= O) NCCO
molekụla Formula C20H39NO2
molekụla arọ 325.5 g / mol
Nkịtị Monoisotopic 325.537 g · mol-1
Melting Point 59 – 60 ° C (138 – 140 ° F; 332 – 333 K)
Esi mmiri 496.4 ± 38.0 Celsius C (Eburu amụma)
njupụta 0.915 ± 0.06 g / cm3 (Eburu amụma)
Agba White
Soke iwe -20 Celsius C
Ngwọta nke ethanol na DMSO Soluble
ngwa Ala Phamaceutical; ngwa-ngwa;

Gịnị bụ Oleoylethanolamide (OEA)?

Oleoylethanolamide (OEA) bụ ihe ngwụcha agbụrụ nke peroxisome proliferator nke na - arụ ọrụ. Ọ bụ ihe ana - eme ya glycolamide lipid nwere ọtụtụ ihe pụrụ iche homeostasis dị ka njikwa agụụ, ọrụ mgbochi mkpali, mkpali nke lipolysis na oxidation abụba. Oleoylethanolamide nwere ike ịtụle homonụ nke eriri afọ nke eriri afọ. Oatmeal, nuts, na koko ntụ bụ isi nri na-eweta Oleoylethanolamide na nri. Agbanyeghị, ego nke Oleoylethanolamide dị na nri ndị a pere mpe (erughị 2 µg / g).

Dika ihe eji eme ka mmanu mmadu noo, emeputara oleylethanolamide (OEA) na eriri afọ na akwara ndị ọzọ, ma na-etinye aka na usoro nchịkwa ume ike, na-achịkwa oriri na ịba uru nke anụ ahụ, dịka ọ nwere ike hazie ihe oriri Vertebrate na oke ahụ. Oleoylethanolamide bụ acid fathan ethanolamide (FAE), analogidon acid anahanamlamide na anandamide na-arụ ọrụ nke anakamide. Ọ dị mma ịmara na Oleoylethanolamide dị iche na anandamide, ọ nọọrọ onwe ya na onye na-anabata cannabinoid, ma na-arụ ọrụ arụmọrụ ya site n'ụzọ ndị ọzọ, na-ahazi ọrụ PPAR-to iji kpalie lipolysis. Oleoylethanolamide bụ ọgwụ nwere ike ịba ụba ma dịkwa nchebe nke dochie ọgwụ antiozim CB1.

Ọmụmụ preclinical egosila na Oleoylethanolamide bụkwa ọgwụ mgbochi dị mma na antioxidant na-egosipụta mmetụta neuroprotective na mmanya. Nlekọta nke oke Oleoylethanolamide nwere ike igbochi nza nke TLR4 na-ebute proinflammatory cascades, si otú ahụ belata ntọhapụ nke cytokines proinflammatory na chemokine, nrụgide oxidative na nitrosative, ma emesịa na-egbochi mmerụ akwara na frontal cortex nke rodents.

Kedu ihe Oleoylethanolamide (OEA) na-arụ?

N'ime ndị mmadụ buru ibu, OEA nwere ike ịhazi ike homeostasis na agụụ tumadi site na mmegharị nke ndị na-anabata ya dị iche iche gụnyere proximal proliferator-activate receptor-α (PPAR-α), G-protein-coupled receptor 119 (GPR119) yana nnata na-anata ọnụnọ nwere oghere cation ọwa subfamily V (TRPV1). N’ezie, OEA na-eme ka ndị nnabata ndị a kwụsịlata ma na-egbu oge ịmalite iri nri, na-ebelata oke nri, na-ebelata oge n’etiti nri ma n’ikpeazụ mezie oke ahụ.

Ọzọkwa, ụfọdụ ọmụmụ nyocha emere gosiri na OEA na-egbochikwa ngosipụta nke IL-6, interleukin-8 (IL-8), intercellular adhesion molecule-1 (ICAM-1) na moasul cell adhesion molecule-1 (VCAM-1) na TNF -nwetara mmerụ ahụ n'ime sel nke akwara ozi endothelial site na ịgbalite nke ndị na-anabata ihe. OEA gbochiri ụzọ nuklia kappa-B (NF-kB) n’ahụ. N'ime nyocha nke YT et al, OEA (50 µmol / L) gbochiri mkpirisi okwu TNF-α VCAM-1 na HUVEC.

Uru Oleoylethanolamide (OEA)

Dị ka onye na-egbochi ceramidase, onye na-ahụ maka ọdịmma nke GPR119 na-anabata, Oleoylethanolamide dị irè megide ọrịa neurodegenerative, anti-atherosclerosis, apoptosis, mgbu mgbu, nkwalite metabolism na-eme ka ọ dịkwuo mma, yana sel ndị dị na sel islet β. Nchedo na ọrịa metabolic ndị ọzọ nwere ezigbo ihe nchebe. Na mgbakwunye, ọ nwere ike belata abụba anụ ahụ site na ịchịkwa agụụ, ịchịkwa ibu, ma nweta oke ibu. Oleoylethanolamide nwekwara ikike iji belata mbufụt na ọkwa cholesterol dị ala.

Oleoylethanolamide (OEA)

  • Ala phamaceutical ubi nri
  • Gaetani S, Oveisi F, Piomelli D (2003). “Mgbanwe usoro erimeri na oke ahụ site na onye ogbugbu mkpụrụ ndụ nke anoreylethanolamine”. Neuropsychopharmacology. 28 (7): 1311–6. doi: 10.1038 / sj.npp.1300166. PMID 12700681.
  • Lo Verme J, Gaetani S, Fu J, Oveisi F, Burton K, Piomelli D (2005). “Iwu nke oriri site n'aka oleoylethanolamine”. Ala. Mol. Ndụ Sci. 62 (6): 708–16. doi: 10.1007 / s00018-004-4494-0. PMID 15770421.
  • Giuseppe Astarita; Bryan C. Rourke; Johnnie B. Andersen; Jin Fu; Janet H. Kim; Albert F. Bennett; James W. Hicks & Daniele Piomelli (2005-12-22). Mmụba oleoylethanolamine na Postprandial na obere eriri afọ nke Burmese Python (Python molurus). Am J Physiol Regul Integr Comp Physiol. 290 (5): R1407 – R1412. doi: 10.1152 / ajpregu.00664.2005. PMID 16373434.
  • Gaetani S, Kaye WH, Cuomo V, Piomelli D (Septemba 2008). "Ọrụ nke endocannabinoids na analolo ha na oke ibu na nsogbu iri nri". Nri Iri Akpiri. 13 (3): e42–8. PMID 19011363.
  • Serrano A, et al. Oleoylethanolamide: mmetụta ndị na-ebugharị hypothalamic na peptides na-achịkwa oriri. Neuropharmacology. (2011)

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