Oleoylethanolamide (OEA) (111-58-0)

March 11, 2020
SKU: 16589-24-5

Oleoylethanolamide (OEA) bu ezigbo peroxisome proliferator-na-eme ka onye na-anabata ihe alpha (PPAR-alpha) agonist. Ọ bụ …… ..

 


ọnọdụ: Na Production Production
Otu: 25kg / Drum

 

Oleoylethanolamide (OEA) (111-58-0) vidiyo

Nkọwa Oleoylethanolamide (OEA) (111-58-0)

 

Product Name Oleoylethanolamide (OEA) ntụ
Chemical Aha n-oleoylethanolamine; N- (2-Hydroxyethyl) oleamide; Oleylethanolamide;

N-oleoyl ethanolamine; Oleamide MEA; Oleoyl monoethanolamide;

Oleoyl Ethanolamide;

CAS Number 111-58-0
InChIKey BOWVQLFMWHZBEF-KTKRTIGZSA-N
Obere CCCCCCCCC = CCCCCCCCC (= O) NCCO
molekụla Formula C20H39NO2
molekụla arọ 325.5 g / mol
Nkịtị Monoisotopic 325.537 g · mol-1
Melting Point 59 – 60 ° C (138 – 140 ° F; 332 – 333 K)
Esi mmiri 496.4 ± 38.0 Celsius C (Eburu amụma)
njupụta 0.915 ± 0.06 g / cm3 (Eburu amụma)
Agba White ntụ ntụ
Soke iwe -20 Celsius C
Ngwọta nke ethanol na DMSO Soluble
ngwa Ala Phamaceutical; ngwa-ngwa;

 

Overview

Oleoylethanolamide (OEA) ma ọ bụ N-Oleoylethanolamide (OEA) bụ molekul na-emepụta n’ime ahụ, nke a na-ahụkarị n’ime eriri afọ. Ihe akaebe na-abawanye na-atụ aro na OEA nwere ike ịrụ ọrụ dị ka ihe na - akpata ụjọ ma na - ekere òkè na njikwa omume ndị metụtara ụgwọ ọrụ. Ọzọkwa, akowara ya dịka onye na-eme ihe ike na-ebelata nri oriri na oke ibu ahụ.

 

Gịnị bụ Oleoylethanolamide (OEA)?

Oleoylethanolamide (OEA) bu ezigbo peroxisome proliferator-na-eme ka onye na-anabata ihe alpha (PPAR-alpha) agonist. Ọ bụ ihe a na-ahụkarị glycolamide lipid na ọtụtụ ihe ndị pụrụ iche nke homeostasis Njirimara dịka nchịkwa agụụ, ọrụ mgbochi mkpali, mkpali nke lipolysis na fatty acid oxidation. Oleoylethanolamide nwere ike iwere ya dị ka hormone nke eriri afọ ụbụrụ. Oatmeal, akụ, na koko ntụ bụ isi ihe oriri sitere na Oleoylethanolamide na nri. Agbanyeghị, ole Oleoylethanolamide dị na nri ndị a pere mpe (erughị 2 µg / g).

Dika ihe eji eme ka mmanu mmadu noo, emeputara oleylethanolamide (OEA) na eriri afọ na akwara ndị ọzọ, ma na-etinye aka na usoro nchịkwa ume ike, na-achịkwa oriri na ịba uru nke anụ ahụ, dịka ọ nwere ike hazie ihe oriri Vertebrate na oke ahụ. Oleoylethanolamide bụ acid fathan ethanolamide (FAE), analogidon acid anahanamlamide na anandamide na-arụ ọrụ nke anakamide. Ọ dị mma ịmara na Oleoylethanolamide dị iche na anandamide, ọ nọọrọ onwe ya na onye na-anabata cannabinoid, ma na-arụ ọrụ arụmọrụ ya site n'ụzọ ndị ọzọ, na-ahazi ọrụ PPAR-to iji kpalie lipolysis. Oleoylethanolamide bụ ọgwụ nwere ike ịba ụba ma dịkwa nchebe nke dochie ọgwụ antiozim CB1.

Ọmụmụ preclinical egosila na Oleoylethanolamide bụkwa ọgwụ mgbochi dị mma na antioxidant na-egosipụta mmetụta neuroprotective na mmanya. Nlekọta nke oke Oleoylethanolamide nwere ike igbochi nza nke TLR4 na-ebute proinflammatory cascades, si otú ahụ belata ntọhapụ nke cytokines proinflammatory na chemokine, nrụgide oxidative na nitrosative, ma emesịa na-egbochi mmerụ akwara na frontal cortex nke rodents.

 

Isi mmalite nke Oleoylethanolamide (OEA)

Enwere ụzọ abụọ maka inweta Oleoylethanolamide (OEA), otu sitere na osisi sitere n'okike, nke ọzọ bụ site na nhazi nke ọma na ụlọ nyocha.

Achyranthes Aspera, onye obodo India, China na ọtụtụ mba ndị ọzọ dị n'Eshia, nwere Oleoylethanolamide OEA. Nsogbu nke Oleoylethanolamide nke sitere n'okike bụ na enwere mkpopụta ruru, 15: 1 bụ ihe a ma ama, ọ bụghịkwa ike dị ka ndị ahịa ma ọ bụ ndị nrụpụta mgbakwunye na-atụ anya. N'ezie, ọ nwere ike ịdị elu, mana ọnụahịa ahụ ga-adị oke oke, yabụ na ọ baghị uru imepụta Oleoylethanolamide OE eke eke na nnukwu.

Isi iyi nke Oleoylethanolamide bụ nke sitere na oleic acid, a rụchara ọrụ dịka N-oleoyl-phosphatidylethanolamine, nke N-acyl-phosphatidylethanolamine-Select phospholipase D (PLD) na-ahọpụta OleoylethanoA.

Oleoylethanolamide bụ metabolite ekeic nke acid. Ya mere, nri na -ewepụta ntakịrị acid bụ ihe dị na OEA.

 

Kedu ka Oleoylethanolamide (OEA) si arụ ọrụ?

N'ime ndị mmadụ buru ibu, OEA nwere ike ịhazi ike homeostasis na agụụ tumadi site na mmegharị nke ndị na-anabata ya dị iche iche gụnyere proximal proliferator-activate receptor-α (PPAR-α), G-protein-coupled receptor 119 (GPR119) yana nnata na-anata ọnụnọ nwere oghere cation ọwa subfamily V (TRPV1). N’ezie, OEA na-eme ka ndị nnabata ndị a kwụsịlata ma na-egbu oge ịmalite iri nri, na-ebelata oke nri, na-ebelata oge n’etiti nri ma n’ikpeazụ mezie oke ahụ.

Ọzọkwa, ụfọdụ nchọpụta nnwale na-egosi na OEA na-egbochikwa okwu nke IL-6, interleukin-8 (IL-8), intercellular adhesion molecule-1 (ICAM-1) na vaskụl cell adhesion molecule-1 (VCAM-1) na TNF - na-ebute mbufụt na eriri afọ nke mkpụrụ ndụ mmadụ site na ịmalite nke ndị nabatara ihe mkpali. OEA gbochikwara ụzọ nuklia nke kappa-B (NF-kB) n'ime ahụ. Na nyocha YT et al, OEA (50 µmol / L) gbochiri TNF-α na-emetụta okwu VCAM-1 na HUVEC.

 

Uru Oleoylethanolamide (OEA)

Oleoylethanolamide (OEA) ntụ dị mma iji felata dị ka onye na-achịkwa agụụ ma na-akwado ọkwa cholesterol dị mma na ndị okenye.

 

Oleoylethanolamide (OEA) dị ka onye na-egbochi agụụ

Ibelata iri nri ma si otua belata nri ị nweta bụ ụzọ dị mma isi jikwaa nguzo ike na oke ahụ. Ebe ọ bụ na agụụ iri nri bụ isi ihe na - egbochi ike (nri) iri nri, ijikwa agụụ dị oke mkpa n'ịchịkwa oke ahụ dị mma, ọkachasị mgbe ejikọtara gị na nhọrọ ndụ nke ahụike nke gụnyere itinye uche na nri nri, inyeju nri, yana mmega ahụ.

Ihe mgbakwunye Oleoylethanolamide na-enyere aka ịchịkwa metabolism lipid, na-enyere aka ịchịkwa agụụ site na izipu ozi na-enweghị atụ na ụbụrụ ma gosipụtara na ọ na-enyere aka belata ma triglyceride na ọkwa cholesterol ọbara.

 

Oleoylethanolamide maka njikwa abụba

OEA bụ usoro nchekwa ihe nchebe karịa na-achịkwa agụụ na mmefu ike.

E buru ụzọ mụọ banyere mmetụta OEA n'ihi na ọ na-agakọ na kemịkal ọzọ, cannabinoid a maara dị ka anandamide. Cannabinoids na osisi Cannabis osisi, na anandamides ndị dị na ahịhịa (na marijuana) nwere ike ịbawanye agụụ mmadụ nwere iri nri site n'ịkpalite azịza nri. Dabere na Wikipedia, Oleoylethanolamide bụ analogamide endocannabinoid anonamide. Ọ bụ ezie na OEA nwere usoro kemịkalụ nke ya na anandamide, mmetụta ya na nri na ịchịkwa ibu dị iche. N'adịghị ka anandamide, OEA na-eme ihe na-enweghị ihe ọ bụla na ụzọ cannabinoid, na-ahazi ọrụ PPAR-to iji kpalie lipolysis.

 

Oleoylethanolamide na-ewuli elu

Onye ọ bụla chọrọ ahụike site na ịgbatị ahụ na mgbatị ahụ. OEA na-ewu ewu maka bodybuilders. Na ubi mmeju, TTA (tetradecylthioacetic acid) na-ejikọkarị ya na oleoylethanolamide (OEA), ha abụọ na - enye aka ịsacha abụba ma belata agụụ. TTA nwekwara ike bụrụ nke na-ekwe nkwa n’etiti ihe ndị na - egbochi abụba, n’ihi na ọ dị ka ọ na --ebu abụba n’enweghị mmega ahụ; Nsonaazụ nke mbụ na-egosi na anụ ahụ pụtara “na-ewepụ” abụba n'ahụ onwe ya kama ịchọ ka emee ka ọ dị ọkụ site na mmega ahụ.

Oleoylethanolamide (OEA) na -ebelata triglycerides na cholesterol, yana, yana onye na-emegide cannabinoid antagonist, na-egbochi oke ahụ mmadụ ma na-eme ka dyslipidaemia nwee ụdị oke ibu.

Na mgbakwunye, achọpụtara sistemalethanolamide na-agbanwe glucose homeostasis, yana mwepụta insulin na akara ngosi insulin na ma hepatocytes na adipocytes.

Refọdụ nyochagharị na-egosi na mgbakwunye oleoylethanolamide nwere mmetụta dị mma na nchekasị, achọrọkwa ụzọ ụkwụ na ihe akaebe iji kwado.

 

Otu esi eji Oleoylethanolamide OEA

 

Ommetụta leoylethanolamide

Oleoylethanolamide OEA dị ọhụrụ na ahịa mgbakwunye, ọ nweghịkwa mmetụta ọjọọ ọ bụla akabeghị. US nri na ọgwụ nchịkwa (FDA) enweghị nchegbu banyere nchekwa OEA. Na ndu ubochi, oleoylethanolamide bu ihe ozo edoghi anya oke ibu, nke eji achoputa oke catabolism na akuku eriri afọ, na-enyere aka belata abuba n’enweghi ihe ojoo n’enweghi nsogbu.

 

Oleoylethanolamide usoro ogwu

Enweghị usoro ọgwụgwọ akwadoro maka oleoylethanolamide ebe ọ bụ na Mmeju oleoylethanolamide ka na-ewu ewu ma n'oge mmalite ya. RiduZone bụ OEA ntụ ntụ nke mbụ emere akara na 2015.

Usoro ọgwụgwọ oleoylethanolamide na-atụ aro bụ otu capsule 200mg mgbe ewere ya na enweghị njikọ ọ bụla

Nnyocha na-egosi na ị nwekwara ike belata ma ọ bụ nwekwuo usoro ọgwụ kwa ụbọchị dabere na ahụ gị dị ukwuu.

100mg maka mmadụ 150lb

145mg maka mmadụ 200lb

180mg maka mmadụ 250lb

 

Ngwa nke Oleoylethanolamide (OEA)

Oleoylethanolamide ntụ ntụ ejirila na mgbakwunye ahụike Ahụike, nke emere n'ime Capsule Hard ma ọ bụ mbadamba maka ọnwụ Weight.

 

Ntughari:

  • Gaetani S, Oveisi F, Piomelli D (2003). "Mgbanwe ụda nke usoro nri na oke site n'aka onye na-egbu egbu egbugbere ọnụ oleoylethanolamine". Neuropsychopharmacology. 28 (7): 1311–6. ma ọ bụ: 10.1038 / sj.npp.1300166. PMID 12700681.

 

  • Lo Verme J, Gaetani S, Fu J, Oveisi F, Burton K, Piomelli D (2005). "Iwu nke iri nri nke oleoylethanolamine". Sel. Mol. Ndụ Ndụ. 62 (6): 708–16. ma ọ bụ: 10.1007 / s00018-004-4494-0. PMID 15770421.

 

  • Giuseppe Astarita; Bryan C. Rourke; Johnnie B. Andersen; Jin Fu; Janet H. Kim; Albert F. Bennett; James W. Hicks & Daniele Piomelli (2005-12-22). "Ọganihu nke posto nke oleoylethanolamine nchịkọta na obere eriri afọ nke eke Burmese (Python molurus)". Am J Physiol Regul Njikọ Ngwakọta Ahụ. 290 (5): R1407 – R1412. ma ọ bụ: 10.1152 / ajpregu.00664.2005. PMID 16373434.

 

  • Gaetani S, Kaye WH, Cuomo V, Piomelli D (Septemba 2008). "Ọrụ nke endocannabinoids na analogues na oke ibu na nsogbu iri nri". Rie Uzo Ozo. 13 (3): e42–8. PMID 19011363.

 

  • Serrano A, et al. Oleoylethanolamide: mmetụta ndị na-ebugharị hypothalamic na peptides na-achịkwa oriri. Neuropharmacology. (2011)