Ganglioside GT1b (59247-13-1)

March 15, 2020

Aha Ganglioside bụ onye ọkà mmụta sayensị German mbụ bụ Ernst Klenk bụ onye mbụ jiri ya mee ihe na 1942 na lipids ọhụrụ dịpụrụ adịpụ site na ụbụrụ ganglion sel… ..

 


ọnọdụ: Na Production Production
Otu: 25kg / Drum

 

Egwuregwu vidiyo Ganglioside GT1b (59247-13-1)

Ganglioside GT1b Smmezi

Product Name Ganglioside GT1b
Chemical Aha GANGLIOSIDE GT1B TRISODIUM Nnu; GT1B 3NA; GT1B-GANGLIOSIDE; GT1B (NH4 + SALT); ganglioside, gt1; (ganglioside gt1B) site na ụbụrụ bovine; trisialoganglioside-gt1b si ụbụrụ bovine; GANGLIOSIDEGT1BTRISODIUMSALT, BOVINEBRAIN; Trisialoganglioside GT1b (NH4 + nnu)
CAS Number 59247-13-1
InChIKey SDFCIPGOAFIMPG-VLTFPFDUSA-N
molekụla Formula C95H162N5Na3O47
molekụla arọ 2158.4 g / mol
Nkịtị Monoisotopic 2157.119189 g / mol
Melting Point N / A
Soke iwe -20 Celsius C
Solubility DMSO: soluble
ngwa Ọgwụ; chromatography;

 

Gịnị bụ Ganglioside GT1b?

Aha German Ganglioside bu onye mbu nke German sayensị Ernst Klenk jiri mee ihe na 1942 na lipids ohuru di iche site na sel ụbụrụ ganglion. Ọ bụ molekul mejupụtara nke glycosphingolipids (ceramides na oligosaccharides) na otu ma ọ bụ karịa sialic acid ndị ejikọtara na agbụ shuga. Ọ bụ akụkụ nke membrane cytoplasmic na-achịkwa ihe omume transduction cellular. A maara ihe karịrị ụdị 60 nke gangliosides, isi ọdịiche dị n'etiti ha bụ ọnọdụ na ọnụ ọgụgụ nke ihe fọdụrụ na NANA.

Ganglioside GT1b bụ otu n'ime ọtụtụ gangliosides na ọ bụ trisialic ganglioside nwere mkpụrụ abụọ sialic acid jikọtara ya na galactose dị n'ime. Ọ nwere inhibitory utịp ke idem humior dịghịzi omume. Na 0.1-10 μM, ọ nwere ike igbochi mmepụta nke IgG, IgM na IgA site na sel mkpụrụ ndụ mononuclear ọbara. Ganglioside GT1b ka a na-atụ aro ka ọ bụrụ onye nnabata mkpụrụ ndụ maka nje cell cell polyoma Merkel yana dịka ụzọ nwere ike ịkpalite ọrịa na-ebute Merkel cell carcinoma.

E tinyekwala Ganglioside GT1b n'ọtụtụ ọrịa kansa ma ewere ya na ọ bụ ganglioside metụtara metastases ụbụrụ. Nnyocha achọpụtala na GM1, GD1a, na GT1b nwere mmetụta inhibitory na akara ngosi nnabata nke epidermal na njigide na keratinocytes, na ọnụnọ ha nwere ike ịbụ ihe ngosipụta bara uru maka ịtụle ikike metastatic ụbụrụ.

Ganglioside GT1b na-emetụtakwa usoro ahụ ji alụso ọrịa ọgụ. Ganglioside GT1b nwere mmetụta na-egbochi mmadụ ịda mbà n'obi ma na-egbochi immunoglobulins nke mkpụrụ ndụ mkpụrụ ndụ mononuclear nke mkpụrụ ndụ mmadụ mepụtara. Enwere ihe akaebe na GD1b, GT1b, na GQ1b nwere ike ịkwalite mmepụta nke cytokines Th1 site na igbochi ọrụ nke adenylate cyclase, ebe na-egbochi mmepụta nke Th2.

Dị ka onye na-anabata ihe dị iche iche nke usoro oligosaccharide, ganglioside GT1b bụ ihe nnabata nke Clostridium botulinum nje botulinum neurotoxin na-abanye na mkpụrụ ndụ akwara. Mmụta emere gosiri na tetanus toxin na-abanye n’ime mkpụrụ ndụ akwara site na ịba ụba na GT1b na gangliosides ndị ọzọ, na-egbochi mwepụta nke neurotransmitters na sistemụ akwara dị n’etiti, ma na-akpata ahụ mkpọnwụ mgbu. Botdị botulinum C nke na-abanye akwara nyochara mmetụta ọ ga-ekwe omume apoptotic nke mkpụrụ ndụ nke ganglioside GT1b mepụtara na neuroblastoma.

Na mgbakwunye, ganglioside GT1b na-achịkwa mmegharị sel, mgbasa, na nrapado na fibronectin (FN) site na njikọta molekul kpọmkwem na α5 subunit nke α5β1 integrin, nchọpụta nke enwere ike iji mepụta usoro ọgwụgwọ ọrịa kansa. Nchikota nke GT1b na MAG n’elu neurons nwere ike mezie nmekorita nke GT1b n’ime olu plasma nke neurons, nke a na - ebute mgbochi nke neurite.

 

Uru Ganglioside GT1b

Ganglioside GT1b bụ glycosphingolipid acidic nke na-akpụpụta mkpụrụ ndụ akwara dị na mkpụrụ ndụ neuronal nke sistemụ akwara ma na-enwe mmụba, ọdịiche, nkwụchi, mmegharị akara, mkparịta ụka cell na sel, tumorigenesis, na metastasis.

Nzaghachi onwe onye na gangliosides nwere ike ibute ọrịa Guillain-Barre. Ganglioside GT1b na-ebute mmebi nke dopaminergic, nke nwere ike itinye aka na mbido ma ọ bụ mmepe nke ọrịa Parkinson.

Ganglioside GT1b bụ onye na-enyocha usoro radieshon nke OH n'efu, nke na-echebe ụbụrụ pụọ na mmebi mtDNA, ọdịdọ na mkpụrụ egbugbere ọnụ nke ndị na-emepụta oxygen na-arụ ọrụ.

Ọrịa Ehrlich na-egosipụta mbupụ ganglioside GT1b, yana mgbochi-GT1b nwere nnukwu ọgwụgwọ dị n'ọrịa a. A na-ejikwa ganglioside a na ọrịa Miller Fisher.

 

Nmetụta nke Ganglioside GT1b

Gangliosides nwere ike kegide lectins, mee ihe dịka ndị na - anabata ya na ndị na - anabata ya na - anabata ya, na - ekere òkè na akara nke mkpụrụ ndụ, ọrịa carcinogenesis na ọdịiche nke mkpụrụ ndụ, na - emetụta nhazi plasta na uto akwara, sonye na nkwụsi ike nke myelin na mmụba akwara, ma na - eme dị ka nje na ntinye uche nke toxins n'ime sel .

Nchịkọta nke ganglioside GT1b nwere ọtụtụ ọrịa gụnyere ọrịa Thai-Sachs na ọrịa Sandhof.

Ganglioside GT1b na-egbochi antigen ma ọ bụ mmeghachi omume nke sel nke T cell ma chọpụta na ọ bụ onye na-anabata nsị botulinum, toxin na-adịghị ahụkebe na nsonaazụ ahụike siri ike.

Ganglioside GT1b dị ihe fọrọ nke nta ka ọ bụrụ nanị na mkpụrụ ndụ akwara ma gosipụta na ọbịbịa. GT1b na-akwalite ọdịiche dị iche iche na nhụjuanya dendritic, nke na-emepụta àgwà ọjọọ ma na-eme ka hyperalgesia na allodynia dịkwuo mma.

Ganglioside GT1b nwere ike imetụta usoro ahụ ji alụso ọrịa ọgụ. O nwere mmechi na-egbochi ahụ mmadụ imi humid na-egbochi ya immunoglobulin nke mkpụrụ ndụ mononuclear mkpụrụ ndụ mmadụ na-emepụta.

Na mgbakwunye, Ganglioside GT1b metụtara ọrịa ndị a: influenza, ọrịa guillain-garré, cholera, tetanus, botulism, ekpenta na oke ibu.

 

Ntughari:

  • Erickson, KD, Garcea, RL, na Tsai, B. Ganglioside GT1b bụ onye na-anabata mkpokọ mkpụrụ ndụ maka polyomavirus Merkel. Journal of Virology 83 (19), 10275-10279 (2009).
  • Kanda, N, na Tamaki, K. Ganglioside GT1b na-egbochi mkpụrụpụta immunoglobulin site na mkpụrụ ndụ mononuclear sel mmadụ. Immunology 96 (4), 628-633 (1999).
  • Schengrund, C.-L., DasGupta, BR, na Ringler, NJ indnweta botulinum na neurotoxins tetanus na ganglioside GT1b na usoro ya. J. Neurochem. 57 (3), 1024-1032 (1991).
  • Gangliosides, nhazi, omume, bayoloji na nyocha ”. Ọbá akwụkwọ Lipid Otu American Chemists Society. Edere site na mbụ na 2009-12-17.
  • Nicole Gaude, Journal nke Ihe Nlekọta Ihe Nlepụta nke Ndụ, Vol. 279: 33 p. 34624-34630, 2004.
  • Elizabeth R Sturgill, Kazuhiro Aoki, Pablo HH Lopez, wdg Biosynthesis nke isi ụbụrụ gangliosides GD1a na GT1b. Glycobiology, Volume 22, Nke 10, Ọktọba 2012, Peeji nke 1289–XNUMX