+ 86 (1360) 2568149 info@phcoker.com

Ganglioside GT1b (59247-13-1)

Onye sayensị sayensị German Ernst Klenk bụ onye mbụ jiri aha Ganglioside mee ya na 1942 nye mkpụrụ ndụ dị iche iche dị na sel ụbụrụ…


ọnọdụ: Na Production Production
Otu: 25kg / Drum

Description

Ganglioside GT1b Smmezi

Product Name Ganglioside GT1b
Chemical Aha GANGLIOSIDE GT1B TRISODIUM SALT; GT1B 3NA; GT1B-GANGLIOSIDE; GT1B (NH4 + SALT); ganglioside, gt1; (ganglioside gt1B) site na ụbụrụ bovine; trisialoganglioside-gt1b sitere na ụbụrụ bovine; GANGLIOSIDEGT1BTRISODIUMSALT, BOVINEBRAIN; Trisialoganglioside GT1b (NH4 + nnu)
CAS Number 59247-13-1
InChIKey SDFCIPGOAFIMPG-VLTFPFDUSA-N
molekụla Formula C95H162N5Na3O47
molekụla arọ 2158.4 g / mol
Nkịtị Monoisotopic 2157.119189 g / mol
Melting Point N / A
Soke iwe -20 Celsius C
Solubility DMSO: soluble
ngwa Ọgwụ; chromatography;

Gịnị bụ Ganglioside GT1b?

Onye sayensị sayensị German Ernst Klenk bụ onye mbụ jiri aha Ganglioside mee ya na 1942 nye mkpụrụ ndụ dịpụrụ adịpụ nke sel ụbụrụ. Ọ bụ molekul mejupụtara glycosphingolipids (ceramides na oligosaccharides) yana otu ma ọ bụ karịa sialic acid jikọtara na yinye siliki. Ọ bụ akụrụngwa nke mejupụtara cytoplasmic nke na-achịkwa ihe omume mkpụrụ ndụ transduction mgbaàmà cellular. A maara ihe karịrị ụdị gangliosides 60, na isi ihe dị n'etiti ha bụ ọnọdụ na ọnụọgụ nke NANA.

Ganglioside GT1b bụ otu n'ime ọtụtụ gangliosides ma bụrụ ọpụpụ nke ganglioside trisialic nwere nsị abụọ sialic acid jikọtara ya na mpaghara galactose. O nwere ihe mgbochi inhibitory na azịza mgbochi anụ ahụ nke anụ ahụ. Na 0.1-10 μM, ọ nwere ike igbochi mmepụta nke IgG, IgM na IgA site na mkpụrụ ndụ mononuclear sel mmadụ. Ekwadoro Ganglioside GT1b ka ọ bụrụ onye nnabata sel maka nje polyoma merkel na ụzọ a ga - esi bute ọrịa na - ebute ọrịa mkpụrụ ndụ Merkel.

E tinyekwala Ganglioside GT1b n'ọtụtụ ọrịa kansa ma ewere ya na ọ bụ ganglioside metụtara metastases ụbụrụ. Nnyocha achọpụtala na GM1, GD1a, na GT1b nwere mmetụta inhibitory na akara ngosi nnabata nke epidermal na njigide na keratinocytes, na ọnụnọ ha nwere ike ịbụ ihe ngosipụta bara uru maka ịtụle ikike metastatic ụbụrụ.

Ganglioside GT1b na-emetụtakwa usoro ahụ ji alụso ọrịa ọgụ. Ganglioside GT1b nwere mmetụta inhibitory na nzaghachi ọgwụ mmadụ na-egbochikwa mmadụ ma gbochie immunoglobulins nke mkpụrụ ndụ mononuclear mepụtara. Enwere ihe akaebe na GD1b, GT1b, na GQ1b nwere ike ịkwalite mmepụta nke cytokines Th1 site na igbochi ọrụ nke adenylate cyclase, ma na-egbochi mmepụta nke Th2.

Dị ka onye na-anabata ihe dị iche iche nke usoro oligosaccharide, ganglioside GT1b bụ ihe nnabata nke Clostridium botulinum nje botulinum neurotoxin na-abanye na mkpụrụ ndụ akwara. Mmụta emere gosiri na tetanus toxin na-abanye n’ime mkpụrụ ndụ akwara site na ịba ụba na GT1b na gangliosides ndị ọzọ, na-egbochi mwepụta nke neurotransmitters na sistemụ akwara dị n’etiti, ma na-akpata ahụ mkpọnwụ mgbu. Botdị botulinum C nke na-abanye akwara nyochara mmetụta ọ ga-ekwe omume apoptotic nke mkpụrụ ndụ nke ganglioside GT1b mepụtara na neuroblastoma.

Na mgbakwunye, ganglioside GT1b na-achịkwa mmegharị sel, mgbasa, na nrapado na fibronectin (FN) site na njikọta molekul kpọmkwem na α5 subunit nke α5β1 integrin, nchọpụta nke enwere ike iji mepụta usoro ọgwụgwọ ọrịa kansa. Nchikota nke GT1b na MAG n’elu neurons nwere ike mezie nmekorita nke GT1b n’ime olu plasma nke neurons, nke a na - ebute mgbochi nke neurite.

Uru Ganglioside GT1b

Ganglioside GT1b bụ glycosphingolipid acidic nke na-akpụpụta mkpụrụ ndụ akwara dị na mkpụrụ ndụ neuronal nke sistemụ akwara ma na-enwe mmụba, ọdịiche, nkwụchi, mmegharị akara, mkparịta ụka cell na sel, tumorigenesis, na metastasis.

Mmeghachi omume onwe onye na gangliosides nwere ike ibute ọrịa Guillain-Barre. Ganglioside GT1b na - akpata nbibi dopaminergic, nke nwere ike itinye aka na mmalite ma ọ bụ mmepe nke ọrịa Parkinson.

Ganglioside GT1b bụ onye na-enyocha usoro radieshon nke OH n'efu, nke na-echebe ụbụrụ pụọ na mmebi mtDNA, ọdịdọ na mkpụrụ egbugbere ọnụ nke ndị na-emepụta oxygen na-arụ ọrụ.

Ọrịa Ehrlich na-egosipụta mbupụ ganglioside GT1b, yana mgbochi-GT1b nwere nnukwu ọgwụgwọ dị n'ọrịa a. A na-ejikwa ganglioside a na ọrịa Miller Fisher.

Nmetụta nke Ganglioside GT1b

Gangliosides nwere ike kegide lectins, mee ihe dịka ndị na - anabata ya na ndị na - anabata ya na - anabata ya, na - ekere òkè na akara nke mkpụrụ ndụ, ọrịa carcinogenesis na ọdịiche nke mkpụrụ ndụ, na - emetụta nhazi plasta na uto akwara, sonye na nkwụsi ike nke myelin na mmụba akwara, ma na - eme dị ka nje na ntinye uche nke toxins n'ime sel .

Nchịkọta nke ganglioside GT1b nwere ọtụtụ ọrịa gụnyere ọrịa Thai-Sachs na ọrịa Sandhof.

Ganglioside GT1b gbochiri mgbochi nje mkpụrụ ndụ T ma ọ bụ mitogen na - akpata ya ma bụrụkwa onye amatagoro dị ka ihe nnabata nke nsị botulinum, ihe nsị na-adịghị ahụkebe yana nsonazụ ya dị egwu.

Ganglioside GT1b dị ihe dị na sel akwara, ana - ekwupụta ya na adventitia. GT1b na-akwalite ọdịiche nke neuronal na usoro dendritic, nke na-arụpụta akparamagwa enweghị nchegbu ma na-akwalite hyperalgesia na allodynia.

Ganglioside GT1b nwere ike imetụta usoro ahụ ji alụso ọrịa ọgụ. O nwere mmetụta mgbochi inhibitory na azịza ahụ mmadụ na - egbochi ma na - egbochi immunoglobulin nke mkpụrụ ndụ mononuclear mepụtara.

Na mgbakwunye, Ganglioside GT1b dị nso na ọrịa ndị na-esonụ: influenza, guillain – garré syndrome, ọgbụgbọ, tetanus, botulism, ekpenta na oke ibu.

Ntughari:

  • Erickson, KD, Garcea, RL, na Tsai, B. Ganglioside GT1b bụ onye na-anabata mkpokọ mkpụrụ ndụ maka polyomavirus Merkel. Journal of Virology 83 (19), 10275-10279 (2009).
  • Kanda, N, na Tamaki, K. Ganglioside GT1b na-egbochi mkpụrụpụta immunoglobulin site na mkpụrụ ndụ mononuclear sel mmadụ. Immunology 96 (4), 628-633 (1999).
  • Schengrund, C.-L., DasGupta, BR, na Ringler, NJ indnweta botulinum na neurotoxins tetanus na ganglioside GT1b na usoro ya. J. Neurochem. 57 (3), 1024-1032 (1991).
  • Gangliosides, usoro, ihe omume, bayoloji na nyocha ”. Ọba akwụkwọ Lipid. Oiltù American Chemists 'Society. Echekwara site na nke mbụ na 2009-12-17.
  • Nicole Gaude, Journal nke Ihe Nlekọta Ihe Nlepụta nke Ndụ, Vol. 279: 33 p. 34624-34630, 2004.
  • Elizabeth R Sturgill, Kazuhiro Aoki, Pablo HH Lopez, wdg Biosynthesis nke isi ụbụrụ gangliosides GD1a na GT1b. Glycobiology, Mpịakọta nke 22, Nke 10, Ọktoba 2012, peeji nke 1289–

NKWUP ANDTA NA NKWU:

A na-ere Ihe Nke A Maka Nchọpụta Naanị. Usoro irere tinye. Ọbụghị maka Oriri mmadu, ma ọ bụ ọgwụ, ọgwụ anụ, ma ọ bụ nke ụlọ.


Video

Egwuregwu vidiyo Ganglioside GT1b (59247-13-1)

COA

Ntughari & akwukwo akwukwo

Shangke Chemical bụ ụlọ ọrụ ọgbara ọhụrụ nke na-ahụ maka ndị na-ahụ maka ọgwụ na-arụ ọrụ (APIs). Iji chịkwaa àgwà n'oge mmepụta, ọnụ ọgụgụ buru ibu nke ndị ọkachamara nwere ahụmahụ, ngwá ọrụ mmepụta mbụ na ụlọ nyocha bụ isi ihe.

Kpọtụrụ Anyị