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Tadalafil uzuzu (171596-29-5)

A na-eji ntụ ntụ Raw Tadalafil n'okpuru aha Cialis na-agwọ ọrịa dysfunction (enweghi ike) yana ihe mgbaàmà nke prostitiki…


ọnọdụ: Na Production Production
Otu: 25kg / Drum
ikike: 1190kg / ọnwa

Description

Tadalafil uzuzu vidiyo

Ozi ala

Product Name Tadalafil uzuzu
Chemical Aha (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione
Brand Name Cialis, Adcirca
Klaasị ọgwụ ọjọọ PAH, PDE-5 Ndị na-eme nchọpụta; Ndị na-eme ihe ntanetị bụ 5 Enzyme
CAS Number 171596-29-5
InChIKey WOXKDUGGOYFFRN-IIBYNOLFSA-N
molekụla Fnhazi C22H19N3O4
molekụla Wasatọ 389.4
Nkịtị Monoisotopic 389.138 g / mol
Mgbu Point 298-300 ° C
Fna-agbanyeghachi Point 2 ℃
Ọkara Ndụ nke Ndụ 17.5 awa
Agba White to Off-White Cyrstalline siri ike
Sume Soluble na DMSO (78 mg / ml na 25 Celsius C), methanol, mmiri (<1 mg / ml na 25 Celsius C), dichloromethane, na ethanol (<1 mg / ml na 25 ° C)
Sịkwa akwa Tigwe Chekwaa n'etiti okpomọkụ dị n'etiti 59 Celsius F na 86 Celsius F (15 Celsius C na 30 Celsius C). Echekwala ọgwụ a na ogwu ma ọ bụ ebe dị egwu.
Tadalafil Antinye Raw Tadalafil powder tablets, Sweighọm Mmekọahụ, Mmekọahụ kọfị, wdg.

Description

Tadalafil, (6R-trans) -6- (1,3-benzodioxol-5-yl) -2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino [1 ', 2': 1,6] pyrido [3,4-b] indole-1,4-dione Cialis), bụ ụdị PDA5 inhibitor na ọgwụ a na-achịkwa ya. Ọ bụ ihe dị na b-carboline ma ọ bụ n'ụkpụrụ ya dị iche na vardenafil (Levitraw) na sildenafil (Viagraw), ha abụọ bụ ndị na - egbochi PDE5. Tadalafil ntụ ntụ (CAS 171596-29-5) na-abawanye usoro ọbara na-abanye n'ime cavernosum corpus site na izulata akwara arịa ọbara, na nke a na-enyere mmadụ aka imezu oke. United States (US) nri na ọgwụ nchịkwa (FDA) masịrị Tadalafil ntụ ntụ maka ọgwụgwọ nke ọrịa dysfunction (ED), wee zụọ ahịa n'ụwa niile n'okpuru aha akara Cialis. A na - ejikwa ya iji gwọọ ọbara ọgbụgba na akwara na - arịa ọrịa ụkwara ume ọkụ na - arịa ọrịa ụkwara ume ọkụ, ọrịa nke na - eme ka ọnọnwụ prostate na - abawanye, na - ebute nsogbu na urination.

Tadalafil nwere ihe omimi nke Tadalafil bụ oge ọkara (ndụ 17.5) nke e jiri ya tụnyere Viagra na Levitra (4-5 awa). Ogologo ndụ a na - arụpụta ogologo oge nke arụ ọrụ, ọ bụkwa akụkụ ya, maka aha aha Cialis nke "ngwụsị izu". Nkeji ndụ a ka bụkwa ihe ndabere nke nchọpụta ugbu a maka iji tadalafil mee ihe na ọbara mgbali elu dịka otu ọgwụgwọ kwa ụbọchị.

Nhazi nke Action

Akwụsị Penile n'oge enwere mmekọahụ na-enweta site na ntụrụndụ nke akwara penile na akwara corpus cavernosal dị nro, na-eme ka ọbara gbanye ọbara ahụ. Ntụrụndụ a na-enye ohere ịbawanye ọbara site na arteries penile, mgbe ọbara a jupụtara ụlọ abụọ n'ime penis a na-akpọ corpora cavernosa. Dika ulo ndi juputa na obara, ihe omuma ahu na-eto. Emeputa na - ejedebe mgbe nkwekorita akwara na ọbara a chịkọtara nwere ike ịpụta site na veins penile.

Mmeghachi omume a na-abụ n’agha n’ịhapụ nitric oxide (NO) site na njedebe akwara na mkpụrụ ndụ endothelial, nke na-akpali njikọta nke cGMP n’ime akwara mkpụrụ ndụ dị mma ma na-ejikwa nsị na ngọngọ nke arịa ọbara nke na-ebuga ọbara na site na amụ. Cyclic GMP na-eme ka izu ike akwara dị mma na ịba ụba nke ọbara na-abanye na corpus cavernosum, ma mebie site na cGMP phosphodiesterase ụdị 5 (PDE5) na corpus cavernosum nke dị n'akụkụ amụ. Tadalafil na-egbochi PDE5 ma si otú a kwalite site na ịba ụba ego nke cGMP dị. Tadalafil na-egbochi PDE5 ka ọ ghara ibibi cGMP wee nwekwuo cGMP dịnụ iji nweta ọrụ ma na-eme ka okpo ọkụ ahụ dị ogologo.

Otú ọ dị, dịka ọkara nke ndụ Tadalafil dị mkpụmkpụ, mmetụta ya na-aga n'ihu n'oge 2 na-eme ka PDE5 laghachi azụ na ahụike gị - na-aka njọ. Ị nwere ike iwe ogologo oge ka ị nweta ihe ị chọrọ, dịka ụbọchị Cialis 4-5 dị ala-ike maka ụbọchị 4-5.

ngwa

  • Erectile dysfunction (ED)
  • Mmiri ọbara mgbali elu nke ọbara
  • Benign prostatic hyperplasia
  • Analgesic
  • Norepinephrine na-egbochi blocker
  • Onye na-anabata onye na-anabata ihe mgbochi

Na-atụ aro Tadalafil ntụ ntụ Dosage

Cialis na-abanye na mbadamba odo, mbadamba ihe nkiri na almond dị na 5, 10 na 20 milligram (mg). Ntụziaka a na-atụ aro maka Cialis ntụ ntụ iji mee ihe dị ka ọ dị mkpa na ọtụtụ ndị ọrịa bụ 10 mg, buru tupu oge elere anya.

Ntinye mbụ bụ 10 milligrams (mg) ọ dịkarịa ala 30 nkeji tupu arụ ọrụ mmekọahụ. Ụdị ahụ nwere ike ịbawanye na 20 mg ma ọ bụ belata na 5 mg, dabere na nrụpụta nke onye ọ bụla na nnabata. Ma, kachasị bụ 20 mg dị ka otu mkpụrụ. Ihe kachasị atụ aro dosing ugboro bụ otu ugboro kwa ụbọchị na ọtụtụ ndị ọrịa. o kwesŽghŽ ŽghaghŽ ihe karŽrŽ otù] z] na oge 24. Ndị ọrịa na-atụ anya inwe mmekọahụ ma ọ dịkarịa ala ugboro abụọ n'izu nwere ike iji ọgwụ 5 mg kwa ụbọchị, nke a nwere ike belata na 2.5 mg otu ugboro kwa ụbọchị, dabere na mmeghachi omume onye ọ bụla.

E gosipụtara ntụ ntụ Cialis maka iji ya mee ihe iji mee ka ọ dịkwuo mma ma e jiri ya tụnyere placebo ruo elekere 36 na-esote dosing. Ya mere, mgbe ị na-enye ndị ọrịa ndụmọdụ gbasara iji Cialis ntụ ntụ mee ihe, ekwesịrị iburu nke a n'uche.

Ọ dị mma ịmara na mgbatị ahụ agaghị apụta nanị site na ị .ụ ọgwụ. Ekwekwala ka Cialis maka nsị ma ọ bụrụ na ị na-ewere Adcirca maka ọbara mgbali elu. N'akụkụ, Tadalafil maka dysfunction bụ naanị maka ndị okenye dị afọ 18 afọ na karịa.

uru

♦ Tadalafil uzuzu nwere ike inyere aka dobe ahụ ike na prostate gị na eriri afo. Nke a nwere ike inyere aka melite mgbaàmà BPH gị.

♦ Iji melite mgbaàmà ED, ntụ ntụ tadalafil enyere aka eme ka ọbara na-abawanye na amụ. Nke a nwere ike inyere gị aka ịnweta ma mechie ụlọ. Maka tadalafil uzuzu iji nyere gị aka inwe ụlọ, ị ghaghị inwe mmekọahụ.

♦ Maka PAH, tadalafil ntụ ntụ na-arụ ọrụ iji melite ike gị iji eme ihe site n'ịkwado arịa ọbara n'ime akpa ume gị. Nke a na-eme ka ọbara na-asọba.

mmetụta

Tinyere mmetụta ndị dị ya mkpa, ọgwụ nwere ike ịkpata mmetụta ndị a na-achọghị. Ọ bụ ezie na ọ bụghị mmetụta ndị a nile nwere ike ime, ọ bụrụ na ha emee, ha nwere ike ịchọ nlekọta ahụ ike. Biko lelee mmetụta ndị na-esonụ nke tadalafil ntụ ntụ:

Mmetụta ndị na-emekarị

▪ isi ọwụwa

▪ iwe iwe

▪ ihe mgbu

▪ ahụ ike

▪ akpụkpọ anụ (ọbara ọbara ọbara)

▪ na-agbaji ma ọ bụ na-agba agba

▪ afọ ọsịsa

Ọ bụ obere mmetụta dị egwu

Mgbatị ogologo oge nke nwere ike iduba na mkparịta ụka, nsogbu ọhụụ, na ụda ntị.

Ọ bụrụ na mmetụta ndị a dị nwayọọ, ha nwere ike ịga n'ime ụbọchị ole na ole ma ọ bụ izu abụọ. Ọ bụrụ na ha ka njọ ma ọ bụ na ha adịghị aga, gwa dọkịta gị ma ọ bụ onye na-enye ọgwụ.

Ndị nwere ọnọdụ ndị a ekwesịghị ikwe Cialis ntụ ntụ ọ gwụla ma dọkịta kwadoro:

Nsogbu obi nke obi, angina, ma ọ bụ ọrịa obi ọ bụla

Ọkwa elu ma ọ bụ ọbara mgbali elu

Mkpụrụ obi obi nkasi obi ma ọ bụ ọrịa strok n'ime ọnwa 6 ikpeazụ, ma ọ bụ nchịkwa myocardial n'ime ọnwa 3 ikpeazụ

Ọrịa Sickle cell, otutu myeloma, hemophilia, leukemia, ma ọ bụ ọrịa ọbara ọzọ

Umeji ma obu akụrụ

Ọkụ ọnyá

Retinitis pigmentos

Mgbazigharị nke mgbatị ahụ, dị ka ọrịa Peyronie

Ahụike ọ bụla a gwara ha ka ha ghara inwe mmekọahụ

Mmekọrịta Tadalafil

Mgbe ị na-eji tadalafil, enwere ọgwụ ndị ọzọ nwere ike imetụta ọgwụ, nke nwere ike ibute mmetụta ndị dị na ya. Mkparịta ụka ọgwụ ọjọọ nwere ike ịgbanwe otú ọgwụ gị si arụ ọrụ ma ọ bụ mekwuo ohere ị nwere maka mmetụta dị njọ.

Tadalafil nwere mmetụta dị mma nke na-eme ka mbelata ọbara na-akpata. Tadalafil nwere ike ime ka ọbara mgbali elu gị dị oké njọ mgbe ejiri ya na nitrates, nke nwere ike iduga nrịanwụ, ịda mbà, ma ọ bụ obere nkụchi obi ma ọ bụ ọrịa strok. Ejila tadalafil mee ihe ọ bụla n'ime ihe ndị a: ụfọdụ ọgwụ eji agwọ ọrịa obi / angina (nitrates dị ka nitroglycerin, isosorbide), ọgwụ ndị a na-akpọ "poppers" nwere amyl ma ọ bụ butyl nitrite.

Ọ bụrụ na ị na-anara ọgwụ mkpịsị aka mkpụrụ (dịka doxazosin, tamsulosin) iji mesoo prostate / BPH ma ọ bụ ọbara mgbali elu, ọbara mgbali elu gị nwere ike ịdalata nke nwere ike iduga nro ma ọ bụ nkwụsị. Dọkịta gị nwere ike ịmalite ịgwọ ọrịa na ụda tadalafil ma ọ bụ gbanwee ọgwụ mkpịsị aka nke mkpụrụ gị ka ị belata ihe ize ndụ nke ọbara mgbali elu.

N'ime ihe omumu banyere ogwu, akuko banyere nzaghachi di omimi rue 36 h na-eso nchikota ogwu. Tadalafil na-ejikarị metabolized n'ime imeju site na CYP3A4 n'ime ndị na-adịghị arụ ọrụ megide PDE5 ma wepụta ihe kachasị dị ka metabolites na feces na mmamịrị. Ihe ndị dị ka iri nri na ị alcoholụbiga mmanya ókè, afọ ọnụnọ, ọnụnọ nke ọrịa shuga, na ọrịa ịba ọcha n'anya na-adịghị ala ala. Ihe kachasị emetụta ọgwụ ọjọọ bụ isi ọwụwa, mgbu azụ, dyspepsia, na myalgia. Na usoro onunu ogwu nke 10 na 20, Tadalafil enweghị mmetụta dị ukwuu na ọbara mgbali elu na ọnụego obi ma ọ dịghị ebute mgbakwunye oge nke infarction myocardial. Achọpụtawo akụkọ ọjọọ nke ogologo oge dị elu karịa 4 h na priapism site na iji tadalafil. Ọ bụrụ na a na - elebara Priapism anya nke ọma, ọ nwere ike ibute nsị anụ ahụ na - agbanwe agbanwe. A na-adụ ndị ọrịa nwere mgbatị dị ogologo karịa 4 h ka ha chọọ nlekọta ahụike mberede. N'ime ndị ọrịa mamịrị, mmụba nke ọrụ site na tadalafil bụ na agbanyeghị ụdị ọrịa shuga na ụdị ọgwụgwọ ọrịa shuga.

Ọgwụ ndị ọzọ nwere ike imetụta mwepụ nke tadalafil si n'ahụ gị, nke nwere ike imetụta otú tadalafil si arụ ọrụ. Ihe ntinye gunyere antigide (dịka heraconazole, ketoconazole), ọgwụ nje macrolide (dịka clarithromycin, erythromycin), ndị na-egbochi nje HIV (dịka fosamprenavir, ritonavir), ịba ọcha n'anya C virus protehibit (dịka boceprevir, telaprevir), rifampin, n'etiti ndị ọzọ .

Ejila ọgwụ a na ngwaahịa ọ bụla ọzọ nke nwere tadalafil ma ọ bụ ọgwụ ndị ọzọ yiri ya iji mee ihe maka dysfunction-ED ma ọ bụ ọbara mgbali (dịka sildenafil, vardenafil).

N'ihe gbasara tadalafil na ọgwụ ndị ọzọ ka nwere nnukwu ihe, ma ọ bụrụ na ịchọrọ iji ọgwụ na tadalafil (CAS 171596-29-5), buru ụzọ cheta dọkịta gị na ọ ga-enye gị ọkachamara ọkachamara na a pụrụ ịdabere na ya.

Ihe omuma

Tadalafil uzuzu, sildenafil uzuzu, na uzuzu vardenafil niile na-eme site na-egbochi ngwongwo PDE5, mana ọgwụ ndị a na-emechikwa PDE enzymes 6, 1, na 11 na ogo dịgasị iche iche. Dịka ọmụmaatụ, Sildenafil na vardenafil na-egbochi PDE6, enzyme dị na anya, karịa tadalafil. Ụfọdụ ndị ọkachamara sildenafil hụrụ ụda na-enweghị atụ ma nwee ọganihu dị elu na ìhè n'ihi nkwụsị PDE6. E wezụga nke ahụ, Sildenafil na vardenafil na-egbochi PDE1 karịa tadalafil. PDE1 dị n'ụbụrụ, obi, na nkwonkwo na-adị ọcha. A na-eche na mgbochi nke PDE1 site na sildenafil na vardenafil na-eduga na vasodilation, flushing, na tachycardia.

E jiri ya tụnyere arụmọrụ na PDE6 na PDE1, tadalafil rụrụ ọrụ na PDE11. A na - egosipụta PDE11 n'ikike skeletal, prostate, imeju, akụrụ, pituitary gland, na testes. Otú ọ dị, a naghị ama mmetụta ndị dị n'ahụ ahụ nke na-egbochi PDE11.

NKWUP ANDTA NA NKWU:

A na-ere Ihe Nke A Maka Nchọpụta Naanị. Usoro irere tinye. Ọbụghị maka Oriri mmadu, ma ọ bụ ọgwụ, ọgwụ anụ, ma ọ bụ nke ụlọ.


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Ntughari & akwukwo akwukwo

References

  • 1.National Center For Information Biotechnology, US. National Library of Medicine, Tadalafil, Pubchem Sections 1-10.
  • 2.Evelyn C. Cortez, CIALIS (Tadalafil): Na-eji, Nkwụsị, Ozi Mgbasa Ozi na Ebee Si Zụta Generic Cialis (Tadalafil), Viagra (Sildenafil), na Ọgwụ Ndị Ọzọ Kasị Mma Dị na Ntanetị na Nchebe na Ntanetị, E bipụtara, 13 Dec 2017, peeji nke 5-3
  • 3.James Lee Anderson, Cialis, Tadalafil: Na-ebute ọrịa Erectile Dysfunction, Mgbaàmà nke Hyperplasia Prostatic Benign, na Ọbara Mgbali Elu nke Pulmonary, CreateSpace Independent Publishing Platform, 26 Mar 2015, 5-47 peeji nke.

Shangke Chemical bụ ụlọ ọrụ ọgbara ọhụrụ nke na-ahụ maka ndị na-ahụ maka ọgwụ na-arụ ọrụ (APIs). Iji chịkwaa àgwà n'oge mmepụta, ọnụ ọgụgụ buru ibu nke ndị ọkachamara nwere ahụmahụ, ngwá ọrụ mmepụta mbụ na ụlọ nyocha bụ isi ihe.

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