Chenodeoxycholic acid (CDCA) ntụ ntụ

January 12, 2022

Chenodeoxycholic acid ntụ ntụ bụ otu n'ime acid bile bụ isi a na-emepụta site na cholesterol n'ime imeju mmadụ na anụmanụ. Enwere ike iji ya na-agwọ ọrịa gallstones na cerebral tendon xanthoma.


ọnọdụ: Na Production Production
Otu: 25kg / Drum
ikike: 1100kg / ọnwa

 

Nkọwapụta Chenodeoxycholic Acid

Product Name Chenodeoxycholic acid
Chemical Aha (R)-4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
Okwu okike Chenodeoxycholic acid;

Anthropodeoxycholic acid;

Anthropodesoxycholic acid;

CCRIS 2195;

Chendol;

chenic acid;

Chenix;

Chenodeoxycholic acid;

Chenodesoxycholic acid;

Chenodiol;

Gallodesoxycholic acid;

NSC 657949;

Xenbilox

CAS Number 474-25-9
InChIKey RUDATBOHQWOJDD-BSWAIDMHSA-N
molekụla Fnhazi C24H40O4
molekụla Wasatọ 392.57
Nkịtị Monoisotopic 392.29265975
Melting Point 165-167 Celsius C (ọkụ)
Esi Point  437.26 Celsius C (ike siri ike)
njupụta 0.9985 (atụmatụ siri ike)
Agba White na-acha ọcha
Solubility  A pụghị ịgwọta ya nke ọma
nchekwa Tigwe  tempili ime ụlọ
ngwa A na-eji Chenodeoxycholic acid mee ihe na nyocha iji nyochaa mmetụta ya dị ka ọgwụgwọ nnọchi ogologo oge maka xanthomatosis cerebrotendinous (CTX). A na-ejikwa ya mee ihe n'ọmụmụ ihe iji nyochaa mmetụta ya na ntinye nke obere eriri afọ nke bile acid na ndị ọrịa nwere ileostomies.
Akuko Ule dị

 

Chenodeoxycholic Acid

Chenodeoxycholic acid, nke a na-akpọkarị chenodiol, bụ ụdị acid bile nke a na-ahụ n'onwe ya na ahụ mmadụ ma na-ejikwa ya eme ihe maka uru chenodeoxycholic acid. A na-atụ aro iji bile acid a maka ọgwụgwọ nke ọnọdụ ahụike dị iche iche na ndụmọdụ ndị a kwadoro site na ihe akaebe sayensị. A mụọla usoro ihe omume nke chenodeoxycholic acid n'ụzọ zuru ezu, n'ọtụtụ ọmụmụ dị iche iche, na nzube nke ịchọta ihe eji eme ihe, uru, na mmetụta nke chenodiol.

 

Kedu ihe bụ Bile acids?

Bile acids bụ, dị ka aha ahụ si akọwa nke ọma, acid steroid nke dị na bile mmadụ na bile nke anụmanụ ndị ọzọ. Bile bụ mmiri na-eri nri nke imeju na-emepụta ma chekwaa ya n'ime eriri afọ. Ọtụtụ n'ime bile acid na-arụ ọrụ na imeju ma nwee ike jikọta ya na amino acid; taurine na glycine, iji mepụta nnu bile.

A na-akpọ acid bile acid nke imeju mebere dị ka acid bile bụ isi ma tinye colic acid na chenodeoxycholic acid. Tupu izobe acid bile ndị a bụ isi, a na-atụgharị ha ka ha bụrụ nnu bile. Ọ bụ nnu bile ndị a ka a na-ahapụzi, ma rute n'ime eriri afọ. N'otu oge na akụkụ duodenal nke obere eriri afọ, a na-ewepụ amino acids nke jikọtara ya na bile acid site na eriri afọ. Ha na-eme mgbanwe ndị ọzọ nke na-eme ka colic acid ghọọ deoxycholic acid na chenodeoxycholic acid n'ime lithocholic acid. Deoxycholic na lithocholic acid bụ bile acid nke abụọ.

Ebe ọ bụ na a na-emepụta bile acid n'ime imeju site na cholesterol, ha nwere usoro mgbanaka steroid dị ka ntọala ha. Nke a bụ otu n'ime ihe kpatara bile acid na-eme dị ka hormones steroid n'ime ahụ ma na-arụ ọrụ dị mkpa na ntụgharị mgbaàmà. Otú ọ dị, isi ọrụ nke bile acids bụ imeziwanye mgbaze nke abụba na mmanụ a na-eri, ha na-eme ya site na gburugburu abụba nri, na-emepụta micele.

A na-etolite Micelle mgbe a na-ekpuchi lipids na nri ma buru ya n'okirikiri nke nnu bile mere. Ọ dị mma ịkọwa na micelles nwere bile acids mana ha sitere na nnu bile nke dina na mmiri na lipid interface. Ọnọdụ ha yana ọdịdị hydroponic na hydrophilic ha na-enye ohere ka nnu bile na-emepụta micelles ndị a na ntinye uche ziri ezi. Ọ dị mkpa iburu n'obi na nhazi nke micelle bụ isi ihe na-eme ka abụba na-agbaji site na enzymes ndị dị mkpa.

Bile acid nwekwara ọrụ ndị ọzọ dị mkpa, otu n'ime ha na-ebelata flora gut, nke dịkwa oke mkpa maka ịmepụta bile acid nke abụọ. Mwepụ cholesterol na ikwado nnabata nke vitamin na-agbaze abụba bụ ụfọdụ ọrụ ndị ọzọ nke bile acid. Ha na-arụ ọrụ dị mkpa na ahụ mmadụ na ihe dị obere dị ka mgbanwe ntinye uche nwere ike gbanwee physiology ahụ nke ọma.

 

Kedu ihe bụ Chenodeoxycholic Acid (CDCA) ntụ ntụ?

Chenodeoxycholic acid ntụ ntụ (474-25-9) ma ọ bụ Chenodiol ntụ ntụ bụ exogenous bile acid nke nwere ike.

a ga-eri ya iji nweta otu uru dị ka nke enwetara site na endogenous chenodiol. A na-eji ntụ ntụ eme ihe n'ụzọ ọgwụgwọ, bụ isi maka ọgwụgwọ ọrịa gallstones, nke bụ naanị nkwụnye ego bile siri ike na gallbladder. Chenodiol nwekwara ike iji na ọgwụgwọ nke ọrịa ndị ọzọ dị ka okwu nke bile synthesis na metabolism. Ọ bụ ọgwụ FDA kwadoro nke a na-edekarị maka ọrịa imeju nke, na isi ha, na-esite na nsogbu na bile.

 

Ebee ka Chenodeoxycholic Acid ntụ ntụ si abịa?

A na-emepụta chenodeoxycholic acid site na mkpụrụ ndụ imeju site na cholesterol. Otú ọ dị, ntụ ntụ chenodiol dịpụrụ adịpụ dịpụrụ adịpụ site na bile nke swan, Cygnus melanocoryphus.

 

Kedu ka Chenodeoxycholic Acid ntụ ntụ si arụ ọrụ?

A na-ejikarị Chenodioxycholic acid ntụ ntụ mee ihe maka ọgwụgwọ nke gallstones, nke a na-ekewa n'ime ụzọ abụọ dabere na ọdịnaya ha na ọdịdị ha na redio. Chenodiol na-enwe ike ịgwọ ọrịa gallstones nke kọlestrọl mejuputara nke ọma ma pụta ìhè radiolucent. Nkume gallstone nke bụ radiopaque ma ọ bụ ọ bụrụ na ha bụ radiolucent ma mejupụtara bile pigmenti, CDCA adịghị agwọ ya.

Chenodiol na-agwọ ọrịa gallstones site n'ịgbaze cholesterol dị n'ime ha bụ nke sitere na biliary cholesterol desaturation site na CDCA ntụ ntụ. Usoro ntụ ntụ nke chenodeoxycholic acid dị mfe, ebe ọ na-egbochi njikọ nke cholesterol na colic acid n'ime imeju. Ka oge na-aga, ọ na-edochi cholic acid na ihe ndị na-emepụta ya n'ime ahụ. N'ihi ya, njupụta nke cholesterol na-ebelata, na-amanye nkume cholesterol ka ọ gbazee maka ịhazi mkpokọta cholesterol.

Mgbe a na-ekwu okwu, chenodiol na-aga n'ime eriri afọ, ebe a na-etinye ya na imeju maka njikọ ya na taurine na glycine residues. Ozugbo ejikọtara ya, nke pụtara na ejikọtala nnu bile, CDCA bile salts na-ahapụ n'ime bile. CDCA bile salts na-anọgide na mgbasa nke enterohepatic nke pụtara na ọkwa serum ma ọ bụ mmamịrị nke CDCA ga-anọgide na-agbanwe agbanwe.

 

Kedu ihe a na-eji Chenodeoxycholic acid?

A na-eji Chenodeoxycolic acid ntụ ntụ maka:

  • Ọgwụgwọ nke radiolucent cholesterol gallstones, enweghị ike ịwa ya n'ihi ọnụnọ nke ọnọdụ ndị ọzọ na-eme ka ịwa ahụ bụrụ nhọrọ siri ike.
  • Ọgwụgwọ nke cerebrotendineous xanthomatosis
  • Ọrụ eriri afọ ka mma na njikwa nke afọ ntachi
  • Ọgwụgwọ nke njehie bu pụta ụwa ma ọ bụ osisi biliary
  • Nlekọta nke hyperlipidemia

 

Kedu ihe dị mkpa Chenodeoxycholic acid na mgbaze?

Chenodeoxycholic acid na-aba uru karịsịa n'ịkwado mgbaze lipid site n'ịme micelles gburugburu acids fatty nke na-abanye n'ime eriri afọ. Ebumnobi a na-akpụ micelle gburugburu lipids bụ ime ka ha na-agbaze mmiri ka e wee bute ha n'elu eriri afọ maka nnabata kacha mma. A na-emepụta Micelles site na nnu bile ma nwee acid bile dị ka chenodeoxycholic acids, n'ihi ya, na-eme ka nke ikpeazụ bụrụ ihe dị mkpa maka ikwado mgbaze lipid n'ime ahụ mmadụ.

 

Gịnị Bụ Uru & Mmetụta nke Chenodeoxycholic Acid ntụ ntụ?

Chenodeoxycholic acid ntụ ntụ bụ FDA kwadoro maka iji na njikwa nke gallstones na ụfọdụ nsogbu ndị ọzọ. Enwere uru ole na ole nke chenodiol nke ndị ọrụ kọwapụtara ma gosipụta ya site na data sayensị siri ike. Ekwesịrị ịtụle uru ndị a mgbe ị na-edepụta ntụ ntụ CDCA iji hụ na uru dị elu karịa ihe ize ndụ.

Nlekọta gallstones bụ isi ọrụ Chenodiol, Otú ọ dị, ọ na-ejikwa ma na-agwọ otu ụdị nkume gallstone. Ọ bụrụ na nkume gallstone abụghị radiolucent ma nwee cholesterol, iji CDCA ntụ ntụ agaghị ezuru maka mgbasa ya. Nnyocha e mere na ebumnuche iji atụnyere nhọrọ ọgwụgwọ dị iche iche maka cholesterol gallstones chọpụtara na iji chenodiol yana lithotripsy bụ ọgwụgwọ nhọrọ. A na-atụ aro Chenodiol karịsịa ma ọ bụrụ na ịwa ahụ nke eriri afọ agaghị abụ nhọrọ dị mma.

Chenodeoxycholic acid ntụ ntụ uru na-agụnyekwa ọgwụgwọ nke ọrịa metabolic dị ka xanthomas cerebrotendinous. Nsogbu a na-agụnye mmụgharị mkpụrụ ndụ ihe nketa na mkpụrụ ndụ ihe nketa nke na-etinye enzyme achọrọ maka ngbanwe nke cholesterol ka ọ bụrụ acid bile n'imeju. Enweghị enzyme a na-ebute mbelata net na njikọ bile acid yana mmụba dị ukwuu na cholesterol nke na-agbakọta na mpaghara dị iche iche nke ahụ, ya mere, na-etolite xanthomas. Ịgwọ ya na exogenous bile acids dị ka chenodiol na-enyere aka ibelata mkpokọta cholesterol n'ime ahụ ma na-emezi ihe mgbaàmà nke ọrịa mkpụrụ ndụ ihe nketa a.

Chenodeoxycholic acid, yana epimer ya, ursodeoxycholic acid, kwenyere na ọ nwere antioxidant na mgbochi mkpali, ọ bụ ezie na a na-ahụ uru ndị a karịa na ursodiol. Chenodiol na-abakwa uru n'ịgwọ njehie amụrụ ime nke metabolism na ọrịa imeju ndị ọzọ.

 

Otu esi ewere ntụ ntụ Chenodeoxycholic acid?

(1) Tupu ị were chenodiol ntụ ntụ

Tupu ịmalite ịṅụ ntụ ntụ chenodeoxycholic, a na-atụ aro ka ị gwa dọkịta na-edepụta ọgwụ niile dị ugbu a na nke gara aga na ọnọdụ ahụike iji jide n'aka na ọ dịghị mmekọrịta ọ bụla nwere ike ịkpata ọnwụ. Dịka ọmụmaatụ, CDCA ntụ ntụ nwere ọtụtụ mmetụta ndị metụtara kpọmkwem na-arụ ọrụ imeju nke mere na-eji ya eme ihe na ọrịa imeju na-egbochi. Ọ dịkwa mkpa ịgwa dọkịta banyere ihe ọ bụla allergies na ọdịnaya nke chendiol mbadamba nkume ma ọ bụ ntụ ntụ, iji hụ na mbelata ihe ize ndụ nke mmetụta.

 

(2)Chenodeoxycholic acid powder usoro onunu ogwu

Chenodiol ntụ ntụ kwesịrị iji ọnụ kwuo, ma ọ bụ nri ma ọ bụ na-enweghị. Kpọmkwem chenodeoxycholic acid ntụ ntụ ntụ ntụ dabere na ịdị arọ nke onye ahụ, ọnọdụ ahụike a na-eji ya, na nzaghachi nke ọgwụgwọ. Ihe akụkụ ikpeazụ pụtara bụ na ọgwụ mbụ na ndebe nke chenodeoxycholic acid ntụ ntụ nwere ike ịdị iche iche dabere n'otú ahụ si emeghachi omume na ya. N'ozuzu, maka okenye, usoro onunu ogwu dị n'etiti 13 mg na 16 mg kwa kilogram nke arọ.

A na-eji ntụ ntụ Chenodiol mee ihe maka ọgwụgwọ nke gallstones, na ebe ọ bụ na ha nwere ike iwepụta ogologo oge maka nkwụsị zuru ezu na nsị, a pụrụ iji ntụ ntụ mee ihe ruo afọ abụọ. Agbanyeghị, mgbe afọ 2 gachara, a ga-akwụsị iji chenodeoxycholic acid n'ihi na bile acid nwere mmetụta hepatotoxic dị ike. Ọzọkwa, mgbaàmà nke gallstones ma ọ bụ ọrịa biliary ndị ọzọ nwere ike were ihe dị ka otu afọ iji pụọ na CDCA ntụ ntụ.

 

(3) Gịnị na-eme ma ọ bụrụ na m na-atụ uche a dose or ịṅụbiga mmanya ókè?

Ọ bụrụ na a na-efunahụ dose nke chenodiol ntụ ntụ, ọ kacha mma ịhapụ nke ahụ ma were usoro ọzọ n'oge mbụ. Ịṅụ ọgwụ ugboro abụọ nwere ike ibute ịṅụbiga mmanya ókè ma akwadoghị ya. Ọ bụ ezie na ọ bụghị ọtụtụ ndị a na-akọ na ịdoụbiga mmanya ókè na chendiol ntụ ntụ, enwere ole na ole na-enye ịdọ aka ná ntị. Ọ bụrụ na a na-atụ anya ịdoụbiga mmanya ókè ma onye ahụ ọ metụtara na-enwe nsogbu iku ume, a ga-achọ enyemaka ahụike ozugbo.

 

(4)Kedu ihe m ga-ezere mgbe ị na-aṅụ chenodiol?

Eji chenodeoxycholic acid ntụ ntụ bụ contraindicated n'ọnọdụ ụfọdụ, dị ka:

  • ịba ọcha n'anya
  • Cirrhosis
  • Ọrịa afọ ime
  • Ọrịa pancreatic
  • Ihe mgbochi na eriri afọ
  • Hemolytic anaemia ma ọ bụ ọrịa ndị ọzọ ma ọ bụ hemolysis
  • Iji mmanya eme ihe mgbe niile
  • Acoụrụma
  • Pregnancy

Ojiji chenodiol n'oge ime ime nwere ike bụrụ nnukwu teratogenic nye nwa ebu n'afọ ma ọ bụ ihe mgbochi kpamkpam. N'oge ị na-enye nwa ara, Otú ọ dị, a maghị ma ọ bụrụ na CDCA bile acid na-abanye n'ime mmiri ara, ya mere, ọ bụ ihe mgbochi. Ị gakwuru dọkịta tupu ịmalite ịṅụ chenodeoxycholic acid ntụ ntụ mgbe a na-enye ndụmọdụ nke ukwuu.

 

Kedu ọgwụ ndị ọzọ ga-emekọrịta na Chenodeoxycholic Acid?

Mmetụta mmetụta chenodeoxycholic acid a na-akọ na-abụkarị n'ihi mmetụta nke bile acid ozugbo, na ọ dịkarịghị n'ihi mmekọrịta nke ntụ ntụ na ọgwụ ndị ọzọ. Otú ọ dị, nke ahụ apụtaghị na chenodeoxycholic acid ntụ ntụ agaghị emekọrịta ihe na ọgwụ ndị ọzọ. Ọ bụrụ na a na-ewere chenodiol na ngwaahịa herbal ma ọ bụ ọgwụ kpọmkwem, mmetụta nke ntụ ntụ ga-agbanwe nke ukwuu. Ihe ize ndụ nke ịmepụta mmetụta ọjọọ ga-abawanye na mmekọrịta ndị a.

Ọgwụ ndị a kapịrị ọnụ nke na-enweghị ike imekọrịta ihe na uzuzu chenodeoxycholic acid bụ:

  • Cholestyramine
  • Colestipol
  • Ọgwụ mgbochi ọmụmụ ma ọ bụ ọgwụgwọ nnọchi homonụ
  • Antacids nwere aluminom dị ka isi ihe ndị dị ka Almacone, Gelusil, Maalox, Mag-al Plus, Mylanta, Rulox, na ndị ọzọ.
  • Ndị na-ebelata ọbara dị ka warfarin, Coumadin, Jantoven.

Cholestyramine na colestipol bụ ndị sequestrants bile acid nke na-eme n'ime afọ site na ọnyà bile acid, ya mere, na-egbochi ọrụ ha. Iji bile acid sequestrants na bile acid ga-eme ka nke ikpeazụ ghara ịdị irè ma ọ nweghị uru a ga-ahụ. Kama nke ahụ, ọnọdụ ahụike nke e nyere chenodeoxycholic acid ga-akawanye njọ.

Ọ dị mkpa ka ị ghara iji chenodiol na ụdị ndị ọzọ nke bile acid n'ihi na nke ahụ nwere ike ime ka ohere nke mmetụta ndị ọzọ dịkwuo elu. A na-atụ aro ka ị gaa na dọkịta na-agwa ha banyere vitamin ma ọ bụ ọgwụ ọ bụla ọzọ mmadụ nwere ike ịṅụ, tupu ịmalite chenodiol dị ka ọgwụ ụfọdụ nwere ike ịkwụsị tupu ịmalite chenodeoxycholic acid. Ọ bụghị naanị nke ahụ, ịkọ ọgwụ ndị ejirila n'oge na-adịbeghị anya wee kwụsịtụ nwekwara ike ịba uru dịka ụfọdụ ọgwụ nwere ike ịnọ na usoro ahụ ogologo oge.

 

Kedu ihe dị iche n'etiti Ursodeoxycholic Acid ntụ ntụ na Chenodeoxycholic Acid ntụ ntụ?

Chenodeoxycholic acid ntụ ntụ na Ursodeoxycholic acid ntụ ntụ bụ abụọ n'ime isi bile acids exogenous nke a na-edepụta ma jiri ya mee ihe maka nchịkwa nke gallstones.

 

Ursodeoxycholic acid ntụ ntụ

Ursodeoxycholic acid ntụ ntụ ma ọ bụ ursodiol bụ bile acid nke abụọ na ahụ mmadụ, nke a na-emepụta site na ngbanwe nke nnu bile site na eriri afọ. N'adịghị ka chenodeoxycholic acid nke bụ isi bile acid na synthesized na imeju, ursodiol na-arụ ọrụ na obere eriri afọ. A na-emepụta ntụ ntụ ursodeoxycholic acid exogenous site na cholic acid nke a na-amịpụta na bile bovine.

 

Ntụle nke uru na ọrụ

A na-eji Ursodiol na Chenodiol mee ihe maka mgbasa gallstone, Otú ọ dị, ojiji ndị ọzọ nke abụọ ahụ adịghị ka nke ahụ. A na-ejikwa Ursodiol maka nlekọta nke biliary cholangitis na isi sclerosing cholangitis. N'ihi profaịlụ nchekwa ya dị elu, ursodiol bụ bile acid nke nhọrọ maka ọgwụgwọ intrahepatic cholestasis nke afọ ime.

 

Nnukwu Ndịiche

Isi ihe dị iche n'etiti chenodeoxycholic acid ntụ ntụ na ursodeoxycholic acid ntụ ntụ bụ na nke ikpeazụ abụghị hepatotoxic na enwere ike iji ya mee ihe n'efu ebe nke mbụ bụ hepatotoxic ma nwee ike ịkpata ọrịa imeju na-egbu egbu. Chenodiol bụ isi bile acid na Ursodiol bụ bile acid nke abụọ yana ịbụ epimer nke chenodiol.

Nnyocha ndị e mere n'oge na-adịbeghị anya bụ ndị e mere iji tụnyere ursodiol na chenodiol chọpụtara na UDCA dị irè karị n'ibelata oke nke gallstones na akara ọnwa 3 na akara ọnwa 6. Otú ọ dị, mgbe ọnwa 12 gachara, arụmọrụ nke ma chenodiol na ursodiol bụ nke ziri ezi ma ọ dịghị nnukwu ọdịiche dị n'etiti abụọ ahụ. Ọzọkwa, achọpụtara na Ursodiol nwere ike ilekwasị anya nke ọma ma na-agwọ nnukwu na obere gallstones ma, nnukwu doses na obere doses. Chenodiol, n'aka nke ọzọ, dị irè naanị n'ibelata oke obere okwute gall na oke doses.

Dị ka ọmụmụ dị iche si kwuo, chenodiol na obere doses jikọtara ya na mmụba nke cholecystectomy.

 

Kedu ihe mmetụta Chenodeoxycholic Acid nwere ike ime?

Mgbe a na-enye chenodeoxycholic acid, a na-atụ aro ka ị na-eso onye ọrịa ahụ ugboro ugboro. Nleta nlebanya ọ bụla kwesịrị ịgụnye nyocha ọbara na isi ihe na-elekwasị anya bụ enzymes imeju. Nke a bụ n'ihi ọdịdị hepatotoxic nke chenodeoxycholic acid. Enwere ike kewaa mmetụta ndị nwere ike ịnweta chenodeoxycholic acid n'ime ụzọ ise, dabere na usoro akụkụ ahụ nke mmetụta ya na-emetụtakarị:

 

Mmetụta hematologic

A kọwo ihe ole na ole nke mmetụta hematologic, na ndị niile metụtara na-akọ na mbelata dị ukwuu na mkpokọta ọbara ọcha. Ntụle ahụ adịghị ada n'okpuru 3000 na n'agbanyeghị mbelata a, a nabatara ọgwụ ahụ nke ọma. Emere mkpebi ịkwụsị CDCA ntụ ntụ maka onye ọ bụla n'ime ndị ọrịa a n'ihi na mmetụta a adịghị ebute nsogbu ahụike ọ bụla.

 

Mmetụta imeju

Chenodeoxycholic acid ntụ ntụ bụ hepatotoxic nke mere na ojiji ya na-contraindicated na ọrịa imeju. Ọzọkwa, hepatotoxicity nke CDCA ntụ ntụ nwere ike ịdị njọ nke ukwuu na nlekota mgbe niile nke enzymes imeju dị oké mkpa mgbe a malitere ọgwụ ahụ. A naghị ahụkarị mmetụta ndị a ma ọ bụrụ na ejiri nlezianya dị mma dịka nlekota oru imeju. Iji chenodiol ntụ ntụ na-enweghị ilekwasị anya na nyocha ọrụ imeju nwere ike ime ka ọrịa imeju na-eyi ndụ egwu.

Ihe mgbaàmà nke ọrịa imeju nwere ike igosi onwe ha na hepatotoxicity nke chenodiol bụ:

  • Anya odo odo
  • Akpụkpọ edo
  • Ọkpụkpụ agba gbara ọchịchịrị
  • Ike na-adịghị ahụkebe na ike ọgwụgwụ
  • Abdominal ihe mgbu
  • Ọgbụgbọ na vomiting na-adịghị edozi

 

Mmetụta nke eriri afọ

Mmetụta ndị a nwere ike ịpụta n'oge ọ bụla n'oge usoro ọgwụgwọ, Otú ọ dị, a na-ahụkarị ha mgbe mmalite ọgwụgwọ ahụ. Nke a bụ mmetụta a na-adịghị ahụkebe n'ihi na ọtụtụ ọgwụ mgbe ejiri ya na mbụ, nwere ike ịkpata mgbakasị afọ ntachi obi. Ihe dị ka pasent 30 ruo pasent 40 nke ndị mmadụ na-ewere chenodiol na-akọ afọ ọsịsa nke anabatara nke ọma na ọ dịghị njọ. Naanị ihe ruru pasentị 15 nke ndị na-arịa afọ ọsịsa dabere na dose chọrọ mbelata dose. Ụfọdụ kọrọ mmụba na mgbaama mgbe ejiri ihe mgbochi afọ ọsịsa gbakwunyere.

Ọ dị obere, a na-achọ nkwụsị nke chenodiol mgbe afọ ọsịsa siri ike yana ọnya afọ na-agwụ ike na-esonyere ya. Tupu ịkwụsị ọgwụ ahụ, ọ dị mkpa ịmata ọdịiche dị n'etiti afọ ọsịsa site na colick, mgbu afọ nke nwere ike ịdị na gallstones. Ịgbaghasị nke ikpeazụ na nke mbụ na ịkwụsị CDCA ntụ ntụ nwere ike imebi ahụike zuru oke.

 

Ụfọdụ n'ime mmetụta ndị na-adịghị ahụkebe nke eriri afọ gụnyere,

  • Nausea na vomiting
  • Egwu
  • Ọkụ obi nro
  • ntachi
  • Dyspepsia
  • Ihe mgbu afọ n'ozuzu ya
  • Ọhụụ
  • anorexia

 

Mkpokọta cholesterol

Enwere ike ịhụ mmụba dị ka pasent 10 na mkpokọta cholesterol na abụba ọjọọ, LDL site n'iji chenodeoxycholic acid ntụ ntụ. Ụmụ nwanyị ole na ole na-ewere bile acid kọkwara mmụba dị nro na ọkwa triglycerides ha, yana mkpokọta cholesterol na LDL. Enweghị mgbanwe na HDL ma ọ bụ ezigbo abụba akọpụtala.

 

Mwepụ gallbladder ma ọ bụ ọnụego cholecystectomy

Ndị mmadụ nwere nkume gallstone na akụkọ ihe mere eme nke mgbu biliary na-achọkarị usoro cholecystectomy dịka ọgwụgwọ maka nkume gallstone ha. Ọzọkwa, ndị ọrịa a enweghịkwa ike ịnagide nnukwu dose chenodeoxycholic acid ntụ ntụ ma nye ha obere doses kama. Enweghị ike ịnagide nnukwu dose CDCA ntụ ntụ, ya mere, ejikọtara ya na ọnụ ọgụgụ cholecystectomy dị elu.

Kedu usoro a na-eme iji hụ na ejiri Chenodeoxycholic Acid dị mma yana nke ọma?

Ndị ọrụ nlekọta ahụike na ndị ọkachamara n'ozuzu na-eduzi nleta ndị na-esochi anya iji nlezianya na-eleba anya maka mmetụta ọ bụla nwere ike ime nke chenodeoxycholic acid ntụ ntụ iji hụ na nchekwa ya na njedebe zuru oke nke ntụ ntụ.

 

Ebee ka m nwere ike nweta ozi ndị ọzọ na Chenodeoxycholic Acid Powder rere?

Maka ozi ndị ọzọ gbasara ire ere ntụ ntụ chenodeoxycholic acid na nnukwu, ị nwere ike iji ihe ntanetị dị ka ebe nrụọrụ weebụ nke dị iche iche chenodeoxycholic acid powder emepụta ma ọ bụ ụlọ ọrụ mmepụta ihe.

 

Nnyocha ndị ọzọ gbasara Chenodeoxycholic Acid

A na-amụ Chenodeoxycholic acid ugbu a maka ojiji ndị ọzọ nwere ike iji ogige ahụ, ewezuga ojiji biliary akọwapụtara. Otu ụlọ ọrụ biotechnology Australia na-amụ chenodiol ugbu a yana ọgwụ na-ebelata lipid, bezafibrate maka ọgwụgwọ ịba ọcha n'anya C.

 

Ọtụtụ mgbe Ẹbụp Ajụjụ

(1)Ntak emi chenodeoxycholic acid (chenodiol) naanị maka ndị ahọpụtara?

Chenodiol bụ bile acid dị ike nke nwere ike inye aka na-agwọ ọrịa gallstones. Agbanyeghị, ọ bụkwa hepatotoxic nwere ike ibute ọrịa imeju siri ike. Nke a bụ ya mere na a naghị atụ aro ya maka ndị nwere ọrịa imeju n'ihi na ihe mgbaàmà nke ọrịa ahụ nwere ike imebiga ihe ókè site na bile acid.

 

(2)Enwere m ike ị were Chenodal (chenodiol) ma ọ bụrụ na m dị ime?

A naghị atụ aro iji chenodiol n'oge ime ime n'ihi ike teratogenic nke ọgwụ ahụ.

 

(3)Ogologo oge ole ka m ga-ewere Chenodal (chenodeoxycholic acid)?

Enwere ike iwere Chenodal ruo afọ abụọ n'otu oge, ọ pụkwara iwere chenodeoxycholic acid CDCA ntụ ntụ ruo otu afọ iji belata mgbaàmà ahụ ma gwọọ ọnọdụ ahụ. Mgbe o jiri CDCA ntụ ntụ mee ihe maka afọ abụọ, ọ dị mkpa iji ezumike.

 

(4)Kedu ihe kpatara eji gwa m ka m hụ onye na-eweta m kwa oge maka ule?

Onye na-ahụ maka gị na-anwale enzymes imeju gị na ọkwa cholesterol iji hụ na ihe niile dị n'ime oke nkịtị, na chenodiol enwebeghị mmetụta ọjọọ ọ bụla na ahụike gị dum. N'ihi oke hepatotoxic ọdịdị nke CDCA ntụ ntụ na ikike ya ịkpata ọrịa imeju ngwa ngwa, onye na-eweta chenodeoxycholic acid ga-ajụ gị kwa oge maka ule. A chọpụtakwara na ọkwa cholesterol na-abawanye site na iji chenodiol, nke bụ ule ọzọ nke onye na-ahụ maka gị ga-arịọ gị.

 

(5)Kedu ọgwụ m kwesịrị izere mgbe m na-aṅụ Chenodal (chenodiol)?

Mgbe ị na-ewere Chenodiol, ị kwesịrị ịkpachara anya na bile acid sequestrants dị ka cholestyramine na colestipol ka ha na-emekọrịta ihe na CDCA ntụ ntụ ma mee ka ojiji ya ghara ịdị irè. A naghị atụ aro ka ị were ọgwụ mgbochi ọbara dị ka warfarin na coumadin, ọgwụ mgbochi ịmụ nwa nwere estrogen n'ime ha, ma ọ bụ antacids na ọgwụ ndị ọzọ nwere aluminom. Ọ bụrụ na ị na-ewere mgbakwunye vitamin ọ bụla, ihe mgbakwunye herbal, na teas herbal, ma ọ bụ ka kwụsịrị ịṅụ ọgwụ, ị ga-agwa dọkịta gị ka ọ hụ na ọ dịghị ọgwụ ọ bụla n'ime ọgwụ gị ugbu a ma ọ bụ na nso nso a na-emekọ ihe na chendiol.

 

Reference

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