5a-hydroxy laxogenin ntụ ntụ

January 10, 2022

5a-hydroxy laxogenin ntụ ntụ nwere anabolic / androgenic ratio nke yiri Anavar ntụ ntụ, ma na-enweghị mmetụta ma ọ bụ imeju toxicity. Ike ga-abawanye na 3-5 ụbọchị, na-adabere muscle uka na-abawanye na 3-4 izu. 5a-hydroxy-laxogenin bụ sapinogen steroid. Nnwale gosiri na njikọ protein mụbara ihe karịrị 200%, isi ihe na-eme ka uru ahụ gbadaa ala na nrụzi ngwa ngwa.

 


ọnọdụ: Na Production Production
Otu: 25kg / Drum
ikike: 1050kg / ọnwa

 

Ozi kemịkalụ nke 5a-hydroxy laxogenin ntụ ntụ

Product Name 5a-hydroxy laxogenin ntụ ntụ
Synonyms 5 alpha-hydroxy laxogenin; 5-alfa-Hydroxy-laxogenin; 5 alfa hydroxy laxogenin; 5-alfa hydroxy laxogenin; 5-alfa-hydroxy laxogenin; 5a hydroxy laxogenin; 5a-hydroxy Laxogenin
Ngwakọta Ọcha > = 99%
CAS Number 56786-63-1
Klaasị ọgwụ ọjọọ Analogue spirostanic nke brassinosteroid
InChI Key HCGPOQBVFMZFY-PPCFKNSFSA-N
Obere CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC(=O)C6(C5(CCC(C6)O)C)O)C)C)OC1
molekụla Formula C27H42O5
molekụla arọ 446.6
Nkịtị Monoisotopic 446.30322444
Melting Point 247-250 ° C
Esi mmiri 578.4 ± 50.0 Celsius C (Eburu amụma)
Enjedebe ọkara ndụ 6-8 awa
Agba White ntụ ntụ
Solubility DMF: 15mg/ml; DMSO: 10mg/mL
Soke iwe Emechiri ya na nkụ, Okpomọkụ ụlọ
ngwa Mgbakwunye; arụrụ arụ; nweta mussule

Ndị na-ewu ahụ́ na ndị na-eme egwuregwu na-anọkarị na-eleba anya maka ụzọ ha ga-esi amụba uru ahụ́ na-esighị ike n’ebughị ibu n’ime ahụ. Otu n'ime ụzọ kachasị mfe iji nweta nke a bụ iji anabolic steroid, ma ogologo oge nke steroid ndị a nwere mmetụta ụfọdụ nke nwere ike ịpụ na-etinye ọtụtụ.

Nnyocha e mere n'oge na-adịbeghị anya achọpụtala ihe ọkụkụ nke ndị ọkà mmụta sayensị kwenyere na ha nwere mmetụta ndị ahụ dị ka steroid nke anabolic, Otú ọ dị, na-enweghị mmetụta ọjọọ ọ bụla nke steroid.

A maara ogige ahụ dị ka 5a hydroxy laxogenin na-emekarị ma ọ bụ site na aha sayensị ya, 5-alpha-hydroxy laxogenin. A na-ere 5a hydroxy laxogenin ntụ ntụ site na ọtụtụ 5a hydroxy laxogenin powder suppliers dị ka ihe mgbakwunye anụ ahụ n'ihi ọtụtụ uru nke ngwaahịa ahụ.

 

Kedu ihe bụ 5a-hydroxy laxogenin?

5a-hydroxy laxogenin, bụ ihe ewepụtara na laxogenin, kemịkalụ a na-ahụ n'okike, na osisi. Laxogenin ma ọ bụ 3beta-hydroxy-25D,5alpha-spirostan-6-otu, bụ ihe ọkụkụ anabolic steroid nke na-ewu ewu n'etiti ndị na-eme egwuregwu na bodybuilders maka uru ahụ na-eme ka ọkpụkpụ ya dịkwuo elu.

Ihe kpatara mmụba nke Laxogenins bụ ọrụ ha na osisi. Ha bụ homonụ nke osisi, nke a makwaara dị ka brassinosteroids nke na-arụ ọrụ na arụ ọrụ, yiri nke anụmanụ na homonụ steroid nke mmadụ. N'ihi nke a, ha na-edochi anabolic steroid.

Enwere ike nweta Laxogenins site na eyịm China ma ọ bụ n'okpuru ala nke osisi Eshia, Smilax sieboldii. Laxogenins, n'ọtụtụ mgbakwunye na-emepụta ma na-ere site na 5a-hydroxy laxogenin powder emeputa, bụ n'ezie sitere na diosgenin steroid ọzọ. A na-ejikwa steorid osisi a na njikọ nke ọtụtụ homonụ sịntetik ndị ọzọ dị ka progesterone, nke a na-ejikarị na ọgwụ mgbochi ịmụ nwa.

Ọtụtụ ụdị nwere 5a hydroxy laxogenin ntụ ntụ maka ire ere, dị ka mgbakwunye, nwere ihe a sitere na laxogenin, nke sitere na diosgenin, kama inwe laxogenin eke. Otú ọ dị, nke a abụghị nke nchegbu ọ bụla dị ka 5-alpha-hydroxy-laxogenin uru dị ka nke laxogenin.

 

5-alpha-hydroxy laxogenin ọ bụ prohormone?

Ọtụtụ ndị na-emepụta 5a hydroxy laxogenin na 5a hydroxy laxogenin ntụ ntụ suppliers na-akpọ ogige ahụ dị ka prohormone. A prohormone bụ ihe na otu ugboro n'ime ahụ, ga-enwe mgbanwe na-aghọ kpọmkwem hormone.

Otu ihe atụ kwesịrị ekwesị ga-abụ androgens, nke na-eme ihe dị ka prohormones na ozugbo etinyere ya na metabolized, gbanwee na hormone, testosterone. 5a hydroxy laxogenin ntụ ntụ abụghị pre-hormone dị ka ọ na-adịghị na-agbanwe n'ime a hormone, kama kama nwere uru yiri nke steroid hormone.

 

5-alpha-hydroxy laxogenin ọ bụ steroid?

5a hydroxy laxogenin bụ steroid nke osisi na-ekerịta ihe ole na ole na homonụ steroid nke anụmanụ. Ọ bụ nke kacha yie homonụ mmekọahụ na ahụ mmadụ nke sitere na cholesterol. Ọ dị mkpa ịkọwapụta na 5a hydroxy laxogenin ntụ ntụ nwere ọrụ na-eto eto na osisi ma mmetụta ya na ahụ mmadụ dị nnọọ mgbagwoju anya karịa nke ahụ.

Kama ịgafe akpụkpọ ahụ ahụ ma mee mgbanwe n'onwe ya, ihe a na-ejikọta ya na onye na-anabata ya ma mee ka agbụ mgbaàmà rụọ ọrụ, nke na-ejedebe na mmụba dị ukwuu na ikike ịmepụta anụ ahụ nke ahụ.

Ụdị protein a kapịrị ọnụ nke 5a hydroxy laxogenin na-arụ ọrụ bụ protein kinase B ma ọ bụ AKT 1. A maara protein a nke ọma maka ike ọ bụghị nanị ịbawanye mmepụta nke uru ahụ n'ime ahụ mmadụ kamakwa maka igbochi nkwụsị nke anụ ahụ.

A na-emebi protein ndị na-edozi ahụ n'oge mgbatị ahụ buru ibu mana a na-eche na uru dị iche iche 5-alpha-hydroxy laxogenin gụnyere igbochi mmebi protein na nkwụsịtụ n'oge mgbatị ahụ.

Usoro ọzọ nke 5a hydroxy laxogenin ntụ ntụ na-emepụta uru ndị na-amasị ndị na-eme egwuregwu na ndị na-eme egwuregwu bụ site na igbochi nkwụsị nke enzyme dị mkpa, ya bụ, cAMP.

Ịba ụba nke enzyme a n'ime ahụ site na igbochi ndakpọ ya na-ebute mmụba nke abụba n'ime ahụ. N'otu oge ahụ, ịba ụba nke enzyme a na-ebutekwa nzaghachi ọgụ ma ọ bụ ụgbọ elu.

N'ozuzu, 5a hydroxy laxogenin powder suppliers na-ere ngwaahịa na-eme ka ahụ ike dịkwuo elu, na-ebelata nkwụsị nke protein, ma na-abawanye mmebi abụba, niile n'otu oge. A kwenyere na mmetụta ndị a na-eme dị ka ndị a bụ mmetụta ndị a na-ahụkarị na ụdị dị iche iche nke 5a hydroxy powder study nke a na-eme ma ọ bụ na ụdị anụmanụ ma ọ bụ na vitro, na ụlọ nyocha. Otú ọ dị, mmetụta ndị a nwere ike ọ gaghị ahụ na ahụ mmadụ mgbe a na-ewere ihe mgbakwunye ndị dị iche iche 5a hydroxy laxogenin powder emepụta.

 

Ọ bụ 5a-hydroxy laxogenin dị ka Laxogenin: 5a hydroxy laxogenin vs laxogenin

5a-hydroxy laxogenin sitere na homonụ osisi, laxogenin. Ha nwere otu uru ahụ, dịka nyocha dị iche iche emere na ụdị anụmanụ. Otú ọ dị, ha abụghị otu ihe.

 

Kedu ihe 5-alpha-hydroxy laxogenin na-eme?

5-alpha hydroxy laxogenin bụ nke kacha yie homonụ mmekọahụ nke emepụtara site na kọlestrọl n'ime ahụ mmadụ. Hormone mmekọahụ ndị a dị na ahụ mmadụ na-arụ ọrụ na ndị na-anabata nuklia, ebe 5a hydroxy laxogenin na-ejikọta ya na onye na-anabata cellular, n'elu cell.

Ọtụtụ ụlọ ọrụ ndị nwere 5a hydroxy laxogenin ntụ ntụ maka ire ere na-erekarị mgbakwunye a na mgbasa ozi na ọ nwere ike ruru 200 pasent ma nwee ike melite ụda akwara n'etiti ndị na-eme egwuregwu. Nkwupụta ndị a sitere n'aka ndị nrụpụta dị iche iche bụ nsonaazụ nke ọtụtụ nyocha emere na ebumnuche iji nyochaa njirimara nkwalite akwara nke laxogenins.

Nnyocha ndị Russia mere n'oge na-adịbeghị anya banyere ụdị anụmanụ chọpụtara na ogige thermogenic sitere n'otu ìgwè nke homonụ osisi dị ka laxogenin, nwere otu mmetụta dị ka laxogenin. Dị ka ọmụmụ a si kwuo, ihe ndị a na-emepụta brassinosteroid nwere ike ịbawanye ọdịnaya protein nke imeju, obi, akụrụ, na akwara ụkwụ. Ọzọkwa, ndị nchọpụta chọpụtara na usoro ndị a arụpụtaghị uru ndị a site n'ichegharị ma ọ bụ iṅomi mmetụta nke homonụ mmekọahụ na ahụ mmadụ.

Nnyocha nyocha ọzọ nke emekwara na ụdị anụmanụ ma jiri homonụ nke otu klas nke homonụ osisi dị ka laxogenin nwere ike imepụtaghachi otu nsonaazụ ahụ dị ka ọmụmụ Russia. Emere ọtụtụ nyocha ndị ọzọ iji hụ na izi ezi nke nsonaazụ ndị a wee chọpụta na ọ dị mfe imepụtaghachi nsonaazụ ya, yabụ na-ekwe nkwa ike na arụmọrụ ha.

Ọ dị mkpa ịkọwapụta na ọ bụ ezie na ọtụtụ ndị na-eji 5a hydroxy laxogenin ntụ ntụ na-azọrọ na ha ga-ahụ nsonaazụ nke ndị na-ere ahịa kpọsara, ịchọta ihe àmà sayensị doro anya iji kwado iji ha eme ihe siri ike. A na-eme ọtụtụ n'ime ọmụmụ ihe n'ụdị anụmanụ ma jiri ogige ndị sitere na klas brassinosteroid nke hormones ma ọ bụ hormone osisi yiri ya, phytoecdysteroids. Laxogenins yiri homonụ ndị a na 5a hydroxy laxogenin bụ ihe sitere na laxogenins, mana nke ahụ anaghị ekwe nkwa otu uru a hụrụ na homonụ ndị ọzọ.

Otu nnyocha e mere site n'iji eke na sịntetik laxogenin na ụlọ nyocha chọpụtara na ntụ ntụ a nwere ike ibelata nrụgide oxidative n'ime ahụ nke ọma. Emere mbelata nrụgide oxidative site na laxogenins site na ibelata radicals n'efu, ụdị ihe na-emerụ ahụ n'ime ahụ nke nwere ike isonye na mmeghachi omume kemịkal dị iche iche wee mebie ahụ nke ọma. Mbelata a na free radicals na oxidative stress nwere ike ịkọwa otú 5a hydroxy laxogenin ntụ ntụ si enwe ike imeziwanye mgbake ahụ ike, post-workout. Agbanyeghị, a ga-emerịrị ihe ọmụmụ a n'ụdị anụmanụ na ihe mmadụ tupu ekwenye na nsonaazụ ọmụmụ.

Emere ihe ọmụmụ niile a kpọtụrụ aha n'elu na ebumnuche nke ịchọpụta ma laxogenins ga-enwe ike ịbawanye ụba nke anụ ahụ na ụda. Otú ọ dị, nanị ojiji nke 5 alpha-hydroxy laxogenin abụghị bodybuilding na nke ahụ bụ ihe ụfọdụ n'ime ndị ọzọ iberibe nke nnyocha na-atụ anya iji gosi.

N'ime ọmụmụ ihe abụọ dị iche iche, iji 5-alpha-hydroxy laxogenin ntụ ntụ na ndị ọrịa cancer colon na-ebelata oke ọrịa cancer. N'otu aka ahụ, a chọpụtara na mmepe nke ọrịa cancer akpa ume na-ebelata site na iji 5a hydroxy laxogenin ntụ ntụ na ụdị anụmanụ. Ọ bụ ezie na ọmụmụ ihe ndị a enweghị ike ịnye ihe akaebe zuru oke nke achọrọ maka mgbakwunye ma ọ bụ ọgwụ ọ bụla a ga-etinye na usoro ọgwụgwọ, ha bụ nzọụkwụ n'ụzọ ziri ezi.

 

Kedu mgbe ị ga-ewere 5-alpha-hydroxy laxogenin?

Usoro ọgwụgwọ 5-alpha-hydroxy laxogenin na-amalite site na 25 mg, nke ahụ bụkwa ego ole mmadụ kwesịrị iji n'oge ọ bụla. Otú ọ dị, ruo 6, na opekempe nke 3, a pụrụ iwere doses n'ime ụbọchị dum, na-eme ka dose nke mgbakwunye ahụ, 150 mg kwa ụbọchị. A na-atụ aro ka ị were ntụ ntụ mgbakwunye nri iji mee ka nnabata dị na afọ.

Enwere ike iwere 5a hydroxy laxogenin ntụ ntụ ruo ọnwa 3 ruo ọnwa 4 n'otu oge n'ihi na nke ahụ bụ mgbe nsonaazụ ga-apụta ìhè. Enwere ike iwere ya na-aga n'ihu ruo ogologo oge karịa nke ahụ ma ọ bụrụ na achọrọ ma ọ bụ chọọ ya. Ebe ọ bụ na ngwakọta eke enweghị mmetụta na ọkwa homonụ nke anụ ahụ, ọ dịghị mkpa ka ejedebe ya na obere oge.

5-alpha-hydroxy laxogenin mmetụta adịghị ama nke ọma n'ihi na ọtụtụ n'ime ọmụmụ ndị a na-eme iji chọpụta arụmọrụ nke mgbakwunye anaghị eme na isiokwu mmadụ. A na-eme ha na ụdị anụmanụ ma ọ gaghị ekwe omume ịchọpụta ma uru na mmetụta ndị sitere na ọmụmụ ihe ndị a. Otú ọ dị, ndị na-eji ihe mgbakwunye ahụ akọpụtaghị ihe ọ bụla toxicities ma ọ bụ mmetụta ọjọọ, nke mere ka nkwenye na mgbakwụnye enweghị mmetụta ọ bụla.

 

Ònye kwesịrị ịtụle iji ya?

Ndị na-arụ ọrụ ahụ, ndị na-eme egwuregwu, na onye ọ bụla ọzọ ga-achọ ịbawanye ụda muscle na oke ma na-ebelata abụba nke anụ ahụ kwesịrị ịtụle iji 5a hydroxy laxogenin ntụ ntụ.

 

5-alpha-hydroxy laxogenin ọ bụ iwu kwadoro?

A na-ewere 5a hydroxy laxogenin dị ka ihe na-akwadoghị iwu nke otu nri na ọgwụ ọjọọ ma ọ bụ FDA na United States enyela ọtụtụ ịdọ aka ná ntị gbasara ya. USADA enyochala ihe a ruo ogologo oge dịka ha achọpụtala na ọ dị na ngwaahịa ma ọ bụ mgbakwunye nke nwekwara ihe ndị ọzọ na-eme ka arụmọrụ dị elu. Ihe ọzọ na-akpata nchegbu na 5a hydroxy laxogenin ntụ ntụ bụ na a na-akpọsa ya dị ka ihe okike, steroid nke dabeere na osisi. Ma FDA na USADA ewelitere ajụjụ gbasara ezigbo isi iyi 5a hydroxy laxogenin dị ka ihe ọkụkụ sitere n'okike na-enye naanị homonụ laxogenin. A kọwabeghị ya ka hydroxy laxogenin si nweta laxogenin.

USADA emeela nyocha zuru ezu nke ntụ ntụ 5a hydroxy laxogenin dị iche iche maka ọrịre wee hụ na ọkara nke mgbakwunye ndị ahụ ka etinyere ya na ihe doping. N'ịgbalị ịzọpụta ndị na-eme egwuregwu na ndị na-arụ ọrụ ahụ site na doping mberede site n'iji 'steroid osisi' a, USADA arịọla ha ka ha na-eleba anya maka ihe mgbakwunye ọ bụla nwere laxogenin nke enwere ike ịkpọ ya na ndepụta mgwa ihe dị ka:

  • UNII-HT7W184YG4
  • HT7W184YG4
  • SCHEMBL4027062
  • ZINC70691911
  • (25r) -3beta-hydroxy-5alpha-spirostan-6-otu
  • Q272800835
  • Alfa-hydroxy-laxogenin
  • 5a-hydroxy-laxogenin
  • 5-laxogenin
  • (25R) -3beta,5alpha-dihydroxyspirostan-6-otu
  • 25-R-spirostan-5a-diol-6-otu-3-otu
  • 25R spirostan-5a-diol-6-otu-3-otu decanoate
  • 25R spirostan-5a-diol-6-otu-3-otu undecanoate

USADA na-enyo enyo na okwu laxogenin na ndepụta ngwa ngwa nwere ike ịbụ ihe ngosi zoro ezo maka ndị na-achọ ihe mgbakwunye doping, nke pụtara na ọ dịghị ezigbo laxogenin ma ọ bụ 5a hydroxy laxogenin na mgbakwunye.

FDA, dị ka USADA, dị iche iche nke laxogenins na nri nri n'ihi na enweghi ozi zuru oke gbasara ojiji, nchekwa, na ike ya. Site na nyocha ndị ọzọ, enwere ike ịnakwere ihe mejupụtara ya dị ka ihe mgbakwunye ike na-akwalite ahụ ike.

Enwere ike ime nke a n'ihi na, n'agbanyeghị na USADA na-ekwupụta laxogenins na usoro ha dị ka ihe iwu na-akwadoghị, ndị ọchịchị na-emegide ọgwụ mgbochi mba ụwa amachibidoghị iji ha eme ihe n'etiti ndị na-eme egwuregwu. 5a hydroxy laxogenin emezughị ihe ekwesịrị ka ekewa ya dị ka ihe eji eme ọgwụ.

Ọzọkwa, ule ọgwụ 5a hydroxy laxogenin agaghị adị mma mgbe ị na-elele ihe doping ma ọ bụrụhaala na emebighị ntụ ntụ ma ọ bụ jiri ihe ndị ọzọ amachibidoro jupụta.

 

Nyocha 5-alfa-hydroxy laxogenin

Ọtụtụ ndị na-eji 5-alpha-hydroxy laxogenin ntụ ntụ na-aṅụ iyi na-ekwu na ha na-ahụ nsonaazụ niile a kpọsara na onwe ha. Ihe fọrọ nke nta ka ọ bụrụ ndị ọrụ niile na-eto mmeju na-eme ngwa ngwa n'ịba ụba akwara na ụda.

Enwere otutu nyocha na ntanetị na-azọrọ na ha ahụla ụda ahụ dị mma na ụbara anụ ahụ dị elu, na-enwe mbelata abụba dị ukwuu na naanị ọnwa atọ ruo ọnwa anọ nke iji 5a hydroxy laxogenin ntụ ntụ.

 

Best 5a-hydroxy laxogenin ntụ ntụ zụta?

Enwere ike zụta ntụ ntụ mgbakwunye site na 5a hydroxy laxogenin ndị na-ebubata ihe na-ere ahịa ma ọ bụrụ na achọrọ ya ma ọ bụ zụta ya na obere ego. Uzuzu kacha mma ịzụta bụ nke arụpụtara, mesoo ya, ma tinye ya na ntuziaka nchekwa siri ike dịka nke a na-ekwe nkwa enweghị mmetọ na ihe amachibidoro 5a hydroxy laxogenin ntụ ntụ.

 

References:

  1. Ngwa na-akwadoghị iwu, 5-Alfa-Hydroxy-Laxogenin, Na-apụta na mgbakwunye ndị ọzọ. Mmụta, Mmụọ nke Egwuregwu / Disemba 4, 2019
  2. Bioorg Med Chem. 2012 Eprel 15; 20 (8): 2690-700 . doi: 10.1016/j.bmc.2012.02.026. Epub 2012 Feb 15. Nghọta ọhụrụ banyere nhazi-cytotoxicity mmekọrịta nke spirostan saponins na glycosides metụtara. Karell Pérez-Labrada, Ignacio Brouard, Sara Estévez, María Teresa Marrero, Francisco Estévez, Jaime Bermejo, Daniel G Rivera. PMID: 22405922
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