Anandamide (AEA) (94421-68-8)

March 15, 2020
SKU: 77472-70-9

Anandamide, nke a makwaara dị ka N-arachidonoylethanolamine (AEA), bụ ọdụdụ abụba na-ebute neurotransmitter sitere na …… ..

 


ọnọdụ: Na Production Production
Otu: 25kg / Drum

 

Anandamide (AEA) (94421-68-8) vidiyo

Anandamide (AEA) (94421-68-8) Smmezi

Product Name Anandamide (AEA)
Chemical Aha Arachidonylethanolamide; N-Arachidonoylethanolamine; Anandamide (20.4, n-6);

N-Arachidonoyl-2-hydroxyethylamide; Arachidonoyl ethanolamide; AEA;

CAS Number 94421-68-8
InChIKey LGEQQWMQCRIYKG-DOFZRALJSA-N
Obere CCCCCC = CCC = CCC = CCC = CCCCC (= O) NCCO
molekụla Formula C22H37NO2
molekụla arọ 347.53
Nkịtị Monoisotopic 347.282429 g / mol
Melting Point N / A
Esi mmiri 522.3 ± 50.0 Celsius C (Eburu amụma)
njupụta 0.92 g / mL na 25 Celsius (ọkụ.)
Agba odo odo
Soke iwe -20 Celsius C
Solubility ethanol: soluble
ngwa A na-eji ya maka ebe nchekwa, mkpali, usoro ọgụgụ isi, njikwa ngagharị, njikwa ihe mgbu, mkpali agụụ na ọmụmụ.

 

Gịnị bụ Anandamide (AEA)?

Anandamide, nke a makwaara dị ka N-arachidonoylethanolamine (AEA), bụ ụbụrụ na-eme ka abụba na-enweta site na nke na-abụghị nke oxidative metabolism nke eicosatetraenoic acid (arachidonic acid.) Ọ nwere usoro yiri nke tetrahydrocannabinol, ihe na-arụ ọrụ nke cannabis. nke kachasị site na fatty acid amide hydrolase (FAAH) enzyme, nke na-agbanwe anandamide n'ime ethanolamine na arachidonic acid, N'ikpeazụ, Anandamide na-arụ ọrụ na neuron site na mmeghachi omume condensation na-eme n'etiti arachidonic acid na ethanolamine n'okpuru iwu nke calcium ion na cyclic monophosphate adenosidase. Ọ bụ ihe bu ụzọ nke otu ihe na-arụ ọrụ ahụ ike (Prostamides) nke na-ekere òkè n'ọtụtụ ọrụ anụ ahụ, gụnyere agụụ, ncheta, ihe mgbu, ịda mba, na ọmụmụ.

Anandamide dị n'ọtụtụ ihe dị ndụ, dị ka mmiri urchin roe, ezì ezi na ezia, wdg, mana ọnụọgụ ya pere mpe. Ọzọkwa, ndị nchọpụta chọpụtakwara Anandamide na ihe abụọ (N-oleoylethanolamine na N-Linoleylethanolamine) na chocolate gbara ọchịchịrị. Anandamide dị na ụfọdụ ọka edozi, (achịcha ọcha), Mmanya na-egbu egbu (kpọmkwem, iji ọgwụ na-adịghị ala ala ma ọ bụ ị drinkingụ oké mmanya), Sugar a nụchara anụcha, abụba trans, nri ndị eghe n'ime mmanụ ihe oriri na nri ndị na-abụghị nri nwere pesticides wdg.

Dị ka akụkụ nke usoro endocannabinoid (ECS), a na-ahọpụta Anandamide dị ka onye na-achịkwa homeostasis yana klas ọzọ nke cannabis-dị ka kemịkal 2-AG na ndị na-anabata cannabinoid na anụ ahụ niile. Usoro a dị na akụkụ niile. Anandamide na-ekere òkè na nhazi nke omume iri nri na mkpali neurogenic na obi ụtọ, na-edebe ahụ anyị na uche anyị. Nnyocha achọpụtala na mmetụta anyị, obi ụtọ, ụjọ, nchekasị, na ikike iji nagide nrụgide bụ nke usoro endocannabinoid na-achịkwa, ọrịa dị iche iche sitere na schizophrenia ruo ịda mba na-esonye na ọkwa anandamide na-adịghị mma.

Anandamide, nke yiri THC, bụ agonist ele mmadụ anya n'ihu nke CB1R. O nwere ike ibute nkwalite ndị nwere ike ịmalite ịrụ ọrụ ụbụrụ nke ọma. Okwesiri ighota na ihe ndia nile anandamide yiri ka odiwanye nma site na igbochi ogwu nke metabolic. Nchọpụta Anandamide nwere ike iduga na mmepe nke ezinụlọ ọhụrụ nke ọgwụ na-agwọ ọrịa.

 

Anandamide (AEA) uru

Anandamide, nke a makwaara dị ka "bliss molecule", bụ nkwalite ọnọdụ, neurotransmitter na endocannabinoid, nke nwere ọtụtụ ahụike na uru ọgụgụ isi:

Anandamide na-ebelata ogwugwo mkpụrụ ndụ cancer ngwa ngwa. Na 1998, otu ndị ọkà mmụta sayensị discoveredtali chọpụtara na anandamide nwere ike ịkwalite neurogenesis ma mepụta akwara ndị ọhụrụ, na-ebelata ike / iwelie uru nke mkpụrụ ndụ kansa ara.

Ikike Anandamide iji kwalite neurogenesis (nhazi nke akwara ozi ọhụrụ) na-ekere òkè n'ịchịkwa omume nri na iwepụta mkpali na obi ụtọ ụmụ oke. Nke a na - enyere aka belata mgbaàmà nke ịda mba na nchekasị. Nnyocha e mere na 2015 nke ụmụ mmadụ na ụmụ oke achọpụtara na ọkwa dị elu nke anandamide nwere ike ịkwalite mmelite ọnọdụ na mbelata ụjọ.

Na mgbakwunye, ikike anandamide nwere ike ijikọ ndị na-anabata CB1 na CB2 ga-emetụtakwa ọtụtụ usoro ọgwụgwọ, na-egosi ezigbo uru maka ncheta, mkpali, usoro ntụgharị uche, njikwa mmegharị, njikwa mgbu, mkpali agụụ na ọmụmụ.

 

Etu esi eme ka anandamide(AEA) ahụ mmadụ?

N'ihi na anandamide nwere ọrụ dị ka onye neurotransmitter, onye na-ahụ vasodilator na metabolite ọbara ọbara, yana ahụike na iche echiche gosipụtara, ị nwere ike chọọ iwelie ọkwa nke anandamide n'ahụ gị. Ndị a bụ ụzọ ụfọdụ iji bulie ogo anandamide nwa oge na ahụ mmadụ:

- Mmega ahụING

Nnyocha ahụ chọpụtara na mgbe naanị nkeji 30 na-agba ọsọ, ọdịnaya anandamide (AEA) nke mmadụ na nkịta mụbara. Yabụ ọ bụrụ na ịchọrọ ị nweta elele kachasị, mee mgbatị ahụ mgbe niile.

- Iri gbara ọchịchịrị chocolate

Chocolate na-agba ọchịchịrị nwere oke of theromromine na chocolate dị mma, ihe ahụ a na-akpọ theromromine na-enyere aka iwelie mmepụta anandamide na ụbụrụ ma belata ọdaji ya nwa oge.

- Na-eri nri ojii

Black truffle (fungus ojii) ndabara nwere anandamide. Ọ bụ ezie na ero ahụ enweghị ike iji anandamide mee ihe n'ụzọ ọ bụla, ndị na-eme nchọpụta kwenyere na a na-eji ya adọta ụmụ anụmanụ ka ha rie ya ma mụta ihe na-akpata ya.

- Na-elekwasị anya

Nnyocha na-egosi na mgbe mmadụ nọ na steeti (nke a na-akpọ "na-asọ" ma ọ bụ "na mpaghara,") nke mgbatị dị elu, arụmọrụ, na itinye uche, ọ bụghị naanị na ị ga-arụpụta ọrụ ma ọ bụ mepụta ọrụ ka mma na ụbụrụ gị Ọ na-ewepụta a ọtụtụ kemịkal, dị ka serotonin, dopamine, endorphin na anandamide.

Ọzọkwa, tii, coriander na celery nwekwara ike inye aka welie mmepụta anandamide.

 

Ntughari:

  • Berger, Alvin; Crozier, nwoke nwere mmasị nwoke; Bisogno, Tiziana; Cavaliere, Paolo; Innis, Sheila; Di Marzo, Vincenzo (15 Mee 2001). "Anandamide na nri: Nsonye nke arachidonate na docosahexaenoate na-eduga n'ọtụtụ ụbụrụ ụbụrụ nke N-acylethanolamines kwekọrọ na piglets". Usoro nke National Academy of Sciences. 98 (11): 6402– Bibcode: 2001PNAS… 98.6402B. ma ọ bụ: 10.1073 / pnas.101119098. PMC 33480. PMID 11353819.
  • El-Talatini MR, Taylor AH, Konje JC (Eprel 2010). "Mmekọrịta dị n'etiti ọkwa plasma nke endocannabinoid, anandamide, nwoke na nwanyị nwere agụụ mmekọahụ, na gonadotrophins n'oge oge ịhụ nsọ". Fatịlaịza. Steril. 93 (6): 1989– iri: 10.1016 / j.fertnstert.2008.12.033. PMID 19200965.
  • Habib, Abdella M .; Okorokov, Andrei L .; Ugwu, Matthew N.; Bras, Jose T.; Lee, Nwoke-Cheung; Li, Shengnan; Ossgba ala, Samuel J .; van Drimmelen, Marie; Morena, Maria (Machị 2019). "Microdeletion na pseudogene mara na onye ọrịa nwere nnukwu anandamide na nchekasị ihe mgbu". British Journal of Anesthesia. 123: e249– doi: 10.1016 / j.bja.2019.02.019. PMID 30929760.
  • Mahler SV, Smith KS, Berridge KC (Nọvemba 2007). "Endocannabinoid hedonic hotspot for sensory ụtọ: anandamide na ntọala accumbens shei na-eme ka 'mmasị' nke ụgwọ ọrụ dị mma". Neuropsychopharmacology. 32 (11): 2267– iche: 10.1038 / sj.npp.1301376. PMID 17406653.
  • Mechoulam R, Fride E (1995). "Roadzọ a na-eteghị aka na ụbụrụ dị egwu cannabinoid ligands, ndị anandamides". Na Pertwee RG (ed.). Cannabinoid ndị nabatara. Boston: Ọmụmụ Press. peeji nke 233– ISBN 978-0-12-551460-6.
  • Mallet PE, Beninger RJ (1996) Nkeji edemede "Onye agonist anonamide nke na - anabata ihe dị egwu na - emebi nchekwa na oke". Ahụhụ Behavioral. 7 (3): 276– iche: 10.1097 / 00008877-199605000-00008.