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Anandamide (AEA) (94421-68-8)

Anandamide, nke a makwaara dị ka N-arachidonoylethanolamine (AEA), bụ neurotransmitter nwere abụba sitere na …… ..


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Description

Anandamide (AEA) (94421-68-8) Smmezi

Product Name Anandamide (AEA)
Chemical Aha Arachidonylethanolamide; N-Arachidonoylethanolamine; Anandamide (20.4, n-6);

N-Arachidonoyl-2-hydroxyethylamide; Arachidonoyl ethanolamide; AEA;

CAS Number 94421-68-8
InChIKey LGEQQWMQCRIYKG-DOFZRALJSA-N
Obere CCCCCC = CCC = CCC = CCC = CCCCC (= O) NCCO
molekụla Formula C22H37NO2
molekụla arọ 347.53
Nkịtị Monoisotopic 347.282429 g / mol
Melting Point N / A
Esi mmiri 522.3 ± 50.0 Celsius C (Eburu amụma)
njupụta 0.92 g / mL na 25 Celsius (ọkụ.)
Agba odo odo
Soke iwe -20 Celsius C
Solubility ethanol: soluble
ngwa A na-eji ya maka ebe nchekwa, mkpali, usoro ọgụgụ isi, njikwa ngagharị, njikwa ihe mgbu, mkpali agụụ na ọmụmụ.

Gịnị bụ Anandamide (AEA)?

Anandamide, nke a makwaara dị ka N-arachidonoylethanolamine (AEA), bụ neurotransmitter na-abụkarị abụba sitere na metabolic eicosatetraenoic acid (arachidonic acid.) Ọ nwere ihe owuwu yiri nke tetrahydrocannabinol, ihe mejupụtara cannabis. mebiri emebi na mbụ site na enzyme fatty acid amide hydrolase (FAAH), nke na-eme ka anandamide ghọọ ethanolamine na arachidonic acid, N’ikpeazụ, Anandamide bụ njikọta neuron site na mmeghachi omume ikuku na-eme n’etiti arachidonic acid na ethanolamine n’okpuru ụkpụrụ nke calcium ion na cyclic monophoidhate. Ọ bụ ihe dị n’ihu nke otu anụ ahụ na - arụ ọrụ (Prostamides) nke na - ekere òkè n’ọtụtụ anụ ahụ, gụnyere agụụ, ncheta, ihe mgbu, ịda mba na ọmụmụ, na Anandamide na - egbochikwa ụmụ mmadụ na - abawanye sel sel kansa.

Anandamide dị na ọtụtụ ihe dị ndụ, dịka oke urchin roe, ụbụrụ ezì na ụmụ oke, wdg, mana ọnụọgụ ya pere mpe. Ọzọkwa, ndị nchọpụta chọpụtakwara Anandamide na ihe abụọ (N-oleoylethanolamine na N-Linoleylethanolamine) na agba gbara ọchịchịrị. Anandamide ọbụna dị n'ụfọdụ ọka edozi, (achịcha ọcha), mmanya na-egbu egbu (ọkachasị, iji ọgwụ na-adịghị ala ala ma ọ bụ ihe ọingụ bụ), shuga a kọchara, nri abụba, nri ndị e ghere eghe na mmanụ oriri na nri ndị na-abụghị ihe nje nke nwere ọgwụ na-egbu ọgwụ wdg.

Dị ka akụkụ nke usoro endocannabinoid (ECS), a na-ahọpụta Anandamide dị ka onye na-achịkwa homeostasis yana klas ọzọ nke cannabis-dị ka kemịkal 2-AG na ndị na-anabata cannabinoid na anụ ahụ niile. Usoro a dị na akụkụ niile. Anandamide na-ekere òkè na nhazi nke omume iri nri na mkpali neurogenic na obi ụtọ, na-edebe ahụ anyị na uche anyị. Nnyocha achọpụtala na mmetụta anyị, obi ụtọ, ụjọ, nchekasị, na ikike iji nagide nrụgide bụ nke usoro endocannabinoid na-achịkwa, ọrịa dị iche iche sitere na schizophrenia ruo ịda mba na-esonye na ọkwa anandamide na-adịghị mma.

Anandamide, nke yiri nke THC, bụ agonist na-ele mmadụ anya n'ihu nke CB1R. O nwere ike ibute nkwalite ike site na “ịgbalite” nke sistemụ ụbụrụ. Ọ dị mma ịmara na mmetụta ndị a nile nke Anandamide yiri ka ọ na-akwalitewanye ọgwụ site na iji gbochie mbibi metabolic ya. Nchoputa nke Anandamide nwere ike ibute mmepe nke ezinulo ohuru nke ogwu ogwu.

Anandamide (AEA) uru

Anandamide, nke a makwaara dị ka “bliss molecule”, bụ onye na-eme ka ọnọdụ adị, neurotransmitter na endocannabinoid, nke nwere ọtụtụ ahụike na uche.

Anandamide na-ebelata ogwugwo mkpụrụ ndụ cancer ngwa ngwa. Na 1998, otu ndị ọkà mmụta sayensị discoveredtali chọpụtara na anandamide nwere ike ịkwalite neurogenesis ma mepụta akwara ndị ọhụrụ, na-ebelata ike / iwelie uru nke mkpụrụ ndụ kansa ara.

Ike Anandamide iji kwalite neurogenesis (imepụta neurons ndị ọhụrụ) na-ekere òkè na ịchịkwa akụrụngwa nri ma na-ebute mkpali na obi ụtọ na ụmụ oke. Nke a na - enyere aka belata ihe mgbaàmà nke ịda mba na nchegbu. Nnyocha na 2015 nke ụmụ mmadụ na ụmụ oke chọpụtara na ọkwa dị elu nke anandamide nwere ike ịkwalite mmezi ọnọdụ na mbelata egwu.

Na mgbakwunye, ike anandamide nwere ike ijikọ ya na ndị na-anabata CB1 na CB2 ga-enwe mmetụta dị ukwuu na usoro physiological, na-egosi uru dị mma na ncheta, mkpali, usoro ọgụgụ isi, njikwa ngagharị, nchịkwa mgbu, mkpali agụụ na ọmụmụ.

Etu esi eme ka anandamide(AEA) ahụ mmadụ?

N'ihi na anandamide nwere ọrụ dị ka onye neurotransmitter, onye na-ahụ vasodilator na metabolite ọbara ọbara, yana ahụike na iche echiche gosipụtara, ị nwere ike chọọ iwelie ọkwa nke anandamide n'ahụ gị. Ndị a bụ ụzọ ụfọdụ iji bulie ogo anandamide nwa oge na ahụ mmadụ:

- Mmega ahụING

Ọmụmụ nchọpụta ahụ chọpụtara na mgbe ọ gbasịrị ọsọ nkeji iri atọ, ihe anandamide (AEA) nke ma mmadụ ma nkịta mụbara. Yabụ ọ bụrụ na ịchọrọ inweta abamuru kachasị, na-eme ụfọdụ mmega ahụ mgbe mgbe.

- Iri ahiri gbara agba

Chocolate na-agba ọchịchịrị nwere oke of theromromine na chocolate dị mma, ihe ahụ a na-akpọ theromromine na-enyere aka iwelie mmepụta anandamide na ụbụrụ ma belata ọdaji ya nwa oge.

- Iri nri oji ojii

Black truffle (fungus ojii) ndabara nwere anandamide. Ọ bụ ezie na ero ahụ enweghị ike iji anandamide mee ihe n'ụzọ ọ bụla, ndị na-eme nchọpụta kwenyere na a na-eji ya adọta ụmụ anụmanụ ka ha rie ya ma mụta ihe na-akpata ya.

- Inweta uche

Nnyocha na-egosi na mgbe mmadụ nọ na ọnọdụ (akpọrọ 'iyi' ma ọ bụ 'na mpaghara,') nke itinye uche, ọrụ na ntinye uche dị elu, ọ bụghị naanị na ị ga-aba ụba karịa ma ọ bụ mepụta ọrụ ka mma na ụbụrụ gị. ọnụ ọgụgụ dị ukwuu nke mmiri ọgwụ, dịka serotonin, dopamine, endorphin na anandamide.

Ọzọkwa, tii, coriander na celery nwekwara ike inye aka welie mmepụta anandamide.

Ntughari:

  • Berger, Alvin; Crozier, Gayle; Bisogno, Tiziana; Cavaliere, Paolo; Innis, Sheila; Di Marzo, Vincenzo (15 Mee 2001). “Anandamide na nri: Nsonye arachidonate na docosahexaenoate na-eduga n'inwe ọkwa ụbụrụ nke N-acylethanolamines nke kwekọrọ na piglets”. Usoro nke National Academy of Sciences. 98 (11): 6402– Bibcode: 2001PNAS… 98.6402B. doi: 10.1073 / pnas.101119098. PMC 33480. PMID 11353819.
  • El-Talatini MR, Taylor AH, Konje JC (Eprel 2010). "Mmekọrịta dị n'etiti ọkwa plasma nke endocannabinoid, anandamide, steroids mmekọahụ, na gonadotrophins n'oge usoro nsọ". Fertil. Steril. 93 (6): 1989– doi: 10.1016 / j.fertnstert.2008.12.033. PMID 19200965.
  • Habib, Abdella M .; Okorokov, Andrei L .; Ugwu, Matthew N .; Bras, Jose T .; Lee, Man-Cheung; Li, Shengnan; Gossage, Samuel J .; van Drimmelen, Marie; Morena, Maria (Maachị 2019). "Microdeletion na pseudogene mata onye ọrịa nwere nnukwu anandamide na ntụgharị ihe mgbu". British Journal of Anesthesia. 123: e249– doi: 10.1016 / j.bja.2019.02.019. PMID 30929760.
  • Mahler SV, Smith KS, Berridge KC (Nọvemba 2007). "Endocannabinoid hedonic hotspot maka ịnụ ụtọ anụ ahụ: anandamide na nucleus accumbens shei na-eme ka 'ị nweta' ụgwọ ọrụ dị ụtọ". Neuropsychopharmacology. 32 (11): 2267– doi: 10.1038 / sj.npp.1301376. PMID 17406653.
  • Mechoulam R, Fride E (1995). "Unzọ a na-emepeghị emepe na ụbụrụ cannabinoid ligands, anandamides". Na Pertwee RG (ed.). Ndị na-anabata Cannabinoid. Boston: Mmụta Ọmụmụ. p. 233– ISBN 978-0-12-551460-6.
  • Mallet PE, Beninger RJ (1996). "Ihe endogenous cannabinoid receptor agonist anandamide na-ebelata ebe nchekwa na oke". Behavioral Pharmacology. 7 (3): 276– doi: 10.1097 / 00008877-199605000-00008.

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