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Raw Lorcaserin HCL powder (846589-98-8)

Raw Lorcaserin hydrochloride powder bụ 2C 5C (2-HTXNUMXC) onye na-anabata ihe na-akwado ya ....


ọnọdụ: Na Production Production
Otu: 25kg / Drum
ikike: 1380kg / ọnwa

Description

Ezu uzo Lorcaserin HCL (846589-98-8) video

Raw Lorcaserin HCL powder (846589-98-8) Nkọwapụta

Product Name Raw Lorcaserin Hydrochloride ntụ ntụ
Chemical Aha Raw Lorcaserin HCL ntụ ntụ, Lorcaserin
Brand Name BELVIQ
Klaasị ọgwụ ọjọọ 5-HT2C onye nkwụnye ihe nkwụnye ihe
CAS Number 846589-98-8
InChIKey ITIHHRMYZPNGRC-QRPNPIFTSA-N
molekụla Fnhazi C11H15Cl2N
molekụla Wasatọ 232.15
Nkịtị Monoisotopic 231.058154899
Mgbu Point Enweghị data dị
Fna-agbanyeghachi Point Enweghị data dị
Ọkara Ndụ nke Ndụ Ọkara ndụ nke ụbụrụ bụ ihe dị ka awa 11.Lorcaserin ntụ ntụ na-ewepụ kpam kpam n'ime mmamịrị (92%) na na feces (2.2%)
Agba White ntụ ntụ
Solubility Mmiri mmiri: 0.0709 mg / ml
nchekwa Tigwe -20 Celsius C.
Antinye Onye na-anakwere onye na-anabata ihe nchịkwa 2C (HT2C) maka ụkọ ọnwụ.Dịbe nri oriri ma na-akwalite sitiety centerrally

Raw Lorcaserin Hcl powder (846589-98-8) Nkọwa

Raw Lorcaserin hydrochloride powder bụ hydrochloride nwetara site na mmeghachi omume nke lorcaserin ntụ ntụ na otu nke hydrochloric acid. Eji ya mee ọgwụ. Lorcaserin hydrochloride bụ agonist natara 5HT2c nke e gosipụtara maka ndị okenye nwere BMI ≥30, ma ọ bụ ndị nwere BMI ≥27 ma ọ dịkarịa ala otu ọnọdụ metụtara ibu dị ka ọbara mgbali elu, ụdị 2 ọrịa shuga ma ọ bụ dyslipidemia.Lorcaserin Hydrochloride ntụ ntụ na-arụ ọrụ site na igbochi agụụ na na-ebute mmetụta nke satiety, a na-echekwa na ọ ga-ezere ọdịda nke ọrịa obi valvular obi na-ejikọta ndị natara 5-HT2B, ebe ụbụrụ a maara na-arụ ọrụ dị mkpa n'ịchịkwa agụụ na nri oriri. Site na ịmepụta ndị a na-anabata, nchịkwa Lorcaserin hydrochloride nwere ike ibelata nri nri site na ebelata ụda na-eme ka mmadụ nwee mmetụta zuru oke ọbụna mgbe o rie nri obere karịa ka ọ dị. kwadoro taa site n'aka FDA na mkpebi dị oke mma mgbe afọ 2 nyochachara.

A na-egosi na ntụzigharị Lorcaserin hydrochloride dị ka ihe dị iche iche na nri dị ala-calorie na ịrụ ọrụ anụ ahụ na-arịwanye elu maka nlekọta ahụike na-adịghị ala ala (BMI nke 30 kg / m2 ma ọ bụ karịa) na ndị buru ibu (BMI nke 27 kg / m2 ma ọ bụ karịa) ya na ọ dịkarịa ala otu ọnọdụ na-abaghị uru.

A na-eji ntụ ntụ nke Lorcaserin hydrochloride mee ihe na nri na mmega ahụ iji na-emeso oke ibu. A na-ejikarị ya eme ihe n'ịba oke ibu nke nwere ike ibute ọrịa shuga, cholesterol dị elu, ma ọ bụ ọbara mgbali elu.

Lorcaserin hydrochloride agaghị agwọ ọrịa ọ bụla (dịka ọrịa obi, ọrịa shuga, ọbara mgbali elu). Nọgide na-ewere ọgwụ ọ bụla dọkịta gị nyere iwu iji mesoo ọnọdụ ndị a.

Ọkụ Lorcaserin Hcl (846589-98-8) Nhazi nke Action

Ọ bụ ezie na amataghị usoro ahụ kpọmkwem, a kwenyere na ọ gụnyere itinye aka nchịkọta nke ndị natara 5-HT2C na mkpụrụ ndụ pro-opiomelanocortin anorexigenic na akwara nke hypothalamus. Nke a na - ebute nri nri na satty site na ịkwalite ịhapụ mkpụrụ ọgwụ alpha-melanocortin na - akpali akpali, nke na - eme ihe na ndị na - anabata 4 melanocortin - XNUMX.

Akpa Lorcaserin hydrochloride na-arụ ọrụ site na ịchịkwa agụụ - kpọmkwem site na ịgbalite ụbụrụ nke ụbụrụ maka serotonin, ụbụrụ nke na-ebute mmetụta nke satiety na afọ ojuju. A na-eji nri sitty center na-ebute ihe oriri, bụ nke na-adị n'ime mkpụrụokwu ventromedial nke hypothalamus na ebe ndị agụụ na-anọ na hypothalamus n'akụkụ. Ihe ntinye dị iche iche site na ebe dị elu na tract gastrointestinal na-agbanye na ngọngọ, bụ ebe ụdị abụọ na-achịkwa nri oriri dị ugbu a. Mbụ, ihe oriri na-akpali agụụ mmekọahụ nke na-emepụta protein na protein neuropeptide Yuta; na nke abuo, otu oriri na-eri nri nke nwere cocaine na amphetamine na-achịkwa transcript (CART) na pro-opiomelanocortin (POMC) neurons. POMC nwere ihe nzaba 5-HT 2C, bụ nke a na - arụ ọrụ na - ahapụ hormone alpha-melanocyte-na - akpali akpali (alfa-MSH) .Ọbụrụ na - emepụta ihe na - akpali akpali na - eme ka ihe ndị ọzọ na - emepụta ihe dị na hypothalamus. Oghere nke mmechi nwere ihe ntanye nke 4 melanocyte (MC4R) nke na-egbochi agụụ na usoro ọgwụgwọ na-emepụta kemikal hydrochloride na-arụ ọrụ dịka agonist 5-HT 2C na-emepụta na POMC, nke nke a na-emekwa ka MSH alfa. Ihe ọzọ MSH MSH na-eme na MC4R na oghere ihe ndị dị na hypothalamus, na-eduga na ibelata agụụ. Na nchịkwa supratherapeutic, lorcaserin hydrochlorider na-emekwa na 5-HT 2B na ndị natara 5-HT 2A.

uru nke ntụ ntụ Lorcaserin Hcl (846589-98-8)

  • Ọkụ Lorcaserin HCL bụ onye na-ahọrọ aghara aghara nke 5-HT2C bụ nke a na-eche iji belata nri oriri site na usoro POMC kachasị. Lorcaserin HCL ntụ ntụ uru:
  • A na-ejikọta ntụ ntụ Lorcaserin HCL na nri na mmega ahụ iji na-emeso oke ibu.
  • A na-ejikarị nkwonkwo Lorcaserin HCL eme ihe mgbe ụfọdụ iji na-emeso oke ibu nke nwere ike ịkọ na ọrịa shuga, cholesterol dị elu, ma ọ bụ ọbara mgbali elu.
  • Mkpụrụ mmanụ Lorcaserin HCL agaghị agwọ ọrịa ọ bụla (dịka ọrịa obi, ọrịa shuga, ọbara mgbali elu).

Na-atụ aro ka ọkụkọ Lorcaserin Hcl (846589-98-8) Dosage

Mkpụrụ mmanụ Lorcaserin HCL na-abata na mbadamba ụrọ na ewere 1-2 ugboro ugboro n'ụbọchị, na-enweghị nri. A ghaghị iji Lorcaserin tinyere nri calorie dị ntakịrị na atụmatụ mmega ahụ.

Ụdị a tụrụ aro nke ụbụrụ lclcaserin hcl bụ 10 mg nke ọnụ na-eji ọnụ ekwu ugboro abụọ n'ụbọchị. Enwere ike ịnabata Lorcaserin n'emeghị nri. A ghaghị kwụsịrị Lorcaserin hcl na ndị ọrịa bụ ndị na-emezughị ihe kachasị 5% ọnwụ site na izu 12 ebe ọ bụ na ndị ọrịa a agaghị enwe mmerụ ahụ dị mkpa na ọgwụgwọ na-aga n'ihu.

mmetụta nke ntụ ntụ Lorcaserin Hcl (846589-98-8)

A na-eji Lorcaserin Hcl lụọ maka ọgwụgwọ nke njedebe na-adịghị arọ nke ndị okenye nwere mkpịsị aka (BMI) nke 30 ma ọ bụ ka ukwuu (obese) dịka ihe mgbakwunye na nri na mmega belata. A nabatara ya maka ndị okenye nwere BMI nke 27 ma ọ bụ karịa (ibu ibu) na ndị nwere ọ dịkarịa ala otu ọnọdụ metụtara ibu dịka ọbara mgbali elu (ọbara mgbali elu), ma ọ bụ cholesterol dị elu (dyslipidemia). Otú ọ dị, ọ nwekwara ike inwe mmetụta ụfọdụ. Dị ka n'okpuru:

Tọ bụ mmetụta kachasị emetụta ya:

  • -Na-amacha,
  • -Dizziness,
  • -Nke ike,
  • -Nausea,
  • -Ndị ọnụ,
  • -Constipation, na
  • -Hypoglycemia (ọbara ọbara ala).

Ihe ndị ọzọ na-adịghị ahụkarị ma ọ bụ dị egwu na-emetụta ya na lorcaserin gụnyere:

  • - Nsogbu valve ụkwụ,
  • - Ngbanwe na anya ma ọ bụ ebe nchekwa,
  • - Nsogbu uche,
  • -Dress or echiche nke igbu onwe,
  • -Akwado ihe ndi ozo,
  • -Ka obi ghara iru gi ala,
  • -Abelata ụlọnga ọbara, na
  • -Anwekwu na hormone, prolactin.

NKWUP ANDTA NA NKWU:

A na-ere Ihe Nke A Maka Nchọpụta Naanị. Usoro irere tinye. Ọbụghị maka Oriri mmadu, ma ọ bụ ọgwụ, ọgwụ anụ, ma ọ bụ nke ụlọ.


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Ntughari & akwukwo akwukwo

FDA kwadoro Lorcaserin HCL Maka Ọgwụgwọ Ibu

References

  1. Bohula, Erin A., Wiviott, Stephen D., McGuire, Darren K., Inzucchi, Silvio E., et al .: Obi Nchedo nke Lorcaserin na Overweight ma ọ bụ Obese Patients, The New England Journal of Medicine, 2018
  2. Nchịkọta nri na ọgwụ ọjọọ, Ngwọta Ejiri Ogologo Ogologo Ogologo, Online, Published 17 July 2012
  3. Ashley Gustafson, Cammile King, Jose AR, National Center for Biotechnology Information, PMC Articles, MediMedia, USA Lorcaserin (Belviq), Online, September 2013

Shangke Chemical bụ ụlọ ọrụ ọgbara ọhụrụ nke na-ahụ maka ndị na-ahụ maka ọgwụ na-arụ ọrụ (APIs). Iji chịkwaa àgwà n'oge mmepụta, ọnụ ọgụgụ buru ibu nke ndị ọkachamara nwere ahụmahụ, ngwá ọrụ mmepụta mbụ na ụlọ nyocha bụ isi ihe.

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