Sulforaphane (4478-93-7)

Description

Sulforaphane Smmezi

Kedu ihe bụ Sulforaphane?

Sulforaphane, makwaara dị ka “dl-sulforaphane”, ọ bụ ihe ọkụkụ sitere n'okike na-achọ n'ọtụtụ akwụkwọ nri ndị dị ka brọkọoli, kabeeji, kọlịflawa, na kale.

Ọ bụ antioxidant a na-ahụkarị na ihe osisi kachasị arụ ọrụ n'ime mkpụrụ osisi. Ọ bụghị naanị Sulforaphane nwere ọrụ mgbochi cancer, mana nwekwara ikike mgbochi oxidation. Achọpụtara ya dị ka otu n'ime ngwaahịa ndị sitere n'okike nwere ọrịa cancer na mmetụta dị mma.

A na-emepụta Sulforaphane mgbe enzyme myrosinase na-agbanwe glucoraphanin, glucosinolate, n'ime sulforaphane mgbe ọ mebiri ihe ọkụkụ (dịka site na ịta ata), nke na-eme ka ogige abụọ ahụ gwakọta ma meghachi omume. Mkpụrụ osisi na-eto eto nke broccoli na kọlịflawa bara ụba na glucoraphanin na sulforaphane.

Sulforaphane (SFN) bụ isothiocyanate, ihe nwere sọlfọ nwere ihe na-egbochi.Sulforaphane ntụ ntụ nwere antioxidant, antimicrobial, anticancer, mgbochi mkpali, mgbochi ịka nká, neuroprotective, na ihe ndị na-egbochi ọrịa mamịrị.

Sulforaphane uru

Uru Ahụike Sulforaphane

FDA anabataghị ọgwụ Sulforaphane maka iji ya wee gwọọ ọrịa, n’enwekwa nnukwu nyocha ụlọ ọgwụ. Iwu na-esetịpụrụ ụkpụrụ maka nrụpụta maka onwe ha mana anaghị ekwe nkwa na ha adịghị mma ma ọ bụ na ọ dị irè.

• na-akwalite detoxification
• na-eme ụbụrụ ụbụrụ
• na-enyere ahụ aka ịmepụta ogige ịlụ ọgụ ọgụ
• na-akwado ọrụ ahụ ike
• na-abawanye glutathione dị ka onye Nrf2 activator
• na-akwalite ibu ibu
• mee ka ịka nká daa site na-eme ka protein ndị na-akpata ọkụ ọkụ
• ikwalite ọrụ umeji
• belata mbufụt na mgbu
• nkwụsị na iweghachi ntutu isi.
• Sulforaphane nwere ike belata cholesterol LDL
• Diabetes

Mkpụrụ osisi Broccoli na-eme ka ọtụtụ ọrịa shuga na-aka mma. N'ime ụdị ndị ọrịa shuga 2, nri broccoli na-epulite ikike antioxidant ọbara na cholesterol HDL, ma belata nrụgide oxidative, triglycerides, insulin, resistance insulin, na CRP.

• Mmebi akpụkpọ ahụ

Sulforaphane nwere ike inye nchebe pụọ na mbufụt UVA na UVB, anwụ na-acha anwụ, na mmebi anụ ahụ.

• Sulforaphane na-ebelata ihe mgbaàmà nke Autism

Sulforaphane nwere ike rụọ ọrụ ụfọdụ mkpụrụ ndụ ihe nketa na-echebe mkpụrụ ndụ pụọ na nchekasị oxidative, mbufụt, na mbibi nke DNA, ihe ndị a niile metụtara ịkpa oke aghara.

• Ihe Omume antiviral

Sulforaphane gosipụtara ọrụ mgbochi mgbe ekpughere sel ndị nwere ọrịa ozugbo

Mmetụta Sulforaphane na nchekwa.

Sulforaphane dị mma ma etinyere ya n'ụdị nri dị. Mana onweghi ozi zuru ezu iji mara ma ọ bụrụ na ọ nweghị nsogbu ọ bụla ọnụ ka ogwu.

Sulforaphane na-eji

Enwere ike iji -Sulforaphane kpochapụ nje na-emerụ ahụ ngụgụ.

–Sulforaphane nwere ọrụ nke mgbochi na ịkwụsịlata ihe mgbu na ọrịa ogbu na nkwonkwo.

-Sulforaphane nwere ike ịmalite usoro ọgwụgwọ ahụ, ngwa ngwa, imezi akụkụ ahụ dị n'ime ise, nwee nguzozi, dozie akụkụ ahụ mebiri emebi, sulforaphane nwere mmetụta nke mgbochi na ọgwụgwọ nke gout.

Enwere ike iji -Sulforaphane mee ihe maka mgbochi kansa. Sulforaphane nwere ike igbochi ọnya afọ, nke atrophic gastritis na-agbanwe cancer cancer

A na-etinye -Sulforaphane na nri nri, sulforaphane bụ ụdị nri nri dị mma iji belata ibu;

A na-etinye -Sulforaphane na ubi ngwaahịa ngwaahịa ahụike, celery nwere ike kwụsie ike ma wepụ iwe iwe;

A na-etinye -Sulforaphane na ngalaba ọgwụ, iji gwọ ọrịa rheumatism na gout nwere ezigbo utịp.

Ọzọ Research

Sulforaphane ntụ ntụ n'ime Ọwara Ọrịa research

Sulforaphane (n'ụdị broccoli pulite wepụ) na-anya ụfọdụ ihe aka ike siri ike maka ọrụ dị na mgbochi nke ọrịa prostate na atụmatụ njikwa maka igbochi ịbịaghachi ọrịa kansa.

N'ọtụtụ ọmụmụ ọgwụ, ụmụ nwoke nwere ọrịa kansa na-arịa prostate na-ewerekarị 60 mg nke sulforaphane kwa ụbọchị nwere ọgwụ mgbochi prostate na-adịghị ala ala (PSA, akara akara na-enwe ọganihu nke ọrịa prostate) karịa ndị na-ewereghị sulforaphane.

Nke a na-ekwu, FDA akwadoghị sulforaphane maka igbochi nlọghachi ọrịa kansa.

Reference:

• Dietary Sulforaphane na Cancer Chemoprevention: Ọrụ nke Epigenetic Regulation na HDAC Inhibition Stephanie M. Tortorella, Simon G. Royce, Paul V. Licciardi, Tom C. Karagiannis Antioxid Redox Signal. 2015 Jun 1; 22 (16): 1382– 1424. doi: 10.1089 / ars.2014.6097 Sulforaphane na-ahazi apoptosis- yana ụzọ mgbaàmà metụtara proliferation ma nwee mmekọrịta na cisplatin iji belata ọrịa kansa ụmụ nwanyị Shi-Feng Kan, Jian Wang, Guan-Xing Sun Int J Mol Med. 2018 Nọvemba; 42 (5): 2447–2458. E bipụtara na ntanetị 2018 Sep 6. doi: 10.3892 / ijmm.2018.3860
• Bioavailability nke Glucoraphanin na Sulforaphane si High ‐ Glucoraphanin Broccoli Tharsini Sivapalan, Antonietta Melchini, Shikha Saha, Paul W. Mkpa, Maria H. Traka, Henri Tapp, Jack R. Dainty, Richard F. Mithen Mol Nutr Food Res. 2018 Septemba; 62 (18): 1700911. E bipụtara na ntanetị 2018 Mar 8. doi: 10.1002 / mnfr.201700911
• Mgbochi Ọrịa Cancer Carcinogen-Induced site n'aka Sulforaphane Julie E. Bauman, Yan Zang, Malabika Sen, Changyou Li, Lin Wang, Patricia A. Egner, Jed W. Fahey, Daniel P. Normolle, Jennifer R. Grandis, Thomas W. Kensler , Daniel E. Johnson Cancer Prev Res (Phila) Akwụkwọ edemede; dị na PMC 2017 Jul 1. E bipụtara ya n'ụdị ikpeazụ edere ka: Cancer Prev Res (Phila). 2016 Jul; 9 (7): 547–557. E bipụtara na ntanetị 2016 Jun 23. doi: 10.1158 / 1940-6207.CAPR-15-0290
• Ọmụmụ nke II nke sulforaphane bara ụba broccoli pupụtara na ụmụ nwoke nwere ọrịa prostate Joshi J. Alumkal, Rachel Slottke, Jacob Schwartzman, Ganesh Cherala, Myrna Munar, Julie N. Graff, Tomasz M. Beer, Christopher W. Ryan, Dennis R. Koop, Angela Gibbs, Lina Gao, Jason F. Flamiatos, Erin Tucker, Richard Kleinschmidt, Motomi Mori Invest New Ọgwụ. Akwụkwọ edemede; dị na PMC 2016 Apr 1. Nke edepụtara na mpempe ikpeazụ edere ka: Invest New Ọgwụ. 2015 Apr; 33 (2): 480–489. E bipụtara ya na ntanetị 2014 Nov 29. doi: 10.1007 / s10637-014-0189-z