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Nicotinamide adenine dinucleotide (53-84-9)

Nicotinamide adenine dinucleotide (NAD) bụ cofactor nke na-enyere aka na metabolism dị na sel niile dị ndụ. Ọ dị n'ụdị abụọ …….


ọnọdụ: Na Production Production
Otu: 25kg / Drum

Description

Nicotinamide adenine dinucleotide (53-84-9) Smmezi

Product Name Nicotinamide adenine dinucleotide (NAD +)
Chemical Aha Nadide; coenzyme I; beta-NAD; beta-NAD +; beta-Diphosphopyridine nucleotide; diphosphopyridine nucleotide; Enzopride;
CAS Number 53-84-9
InChIKey BAWFJGJZGIEFAR-NNYOXOHSSA-N
Obere C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N
molekụla Formula C21H27N7O14P2
molekụla arọ 663.4 g / mol
Nkịtị Monoisotopic 663.109123 g / mol
Melting Point 160 ° C (320 ° F; 433 K)
Agba White
Soke iwe 2-8 ° C
Solubility H2O: 50 mg / mL
ngwa Nri mara mma, ihe ntecha, nri nri

Gịnị bụ Nicotinamide adenine dinucleotide(NAD +)?

Nicotinamide adenine dinucleotide (NAD) bụ cofactor nke na-enyere aka na metabolism dị na sel niile dị ndụ. Ọ dị n'ụdị abụọ, oxidized (NAD +) na belata (NADH).

Coenzyme NAD +, ụdị oxidized nke NAD, bu ụzọ chọpụta na 1906 site na ndị na-ahụ maka biochemist Arthur Harden na William John Young. A na-agwakọta NAD + site na ụzọ abụọ metabolic, nke enwere ike isi na ụzọ no nosi amino acid mepụta, ma ọ bụ enwere ike mepụta ya site na ntughari mmiri (dịka nicotinamide) laghachi na ụzọ nnapụta nke NAD +. Ọ bụ pyridine nucleotide dị mkpa ma na-arụ ọrụ dị ka cofactor na mkpụrụ maka ọtụtụ usoro mkpụrụ ndụ ekwentị nke metụtara phosphorylation oxidative na mmepụta ATP, mmezi DNA, nhazi iwu nke onyinye mkpụrụ ndụ, ihe ngosipụta akwara intracellular na ọrụ Immunological.

NAD + bụ isi ihe na - anabata ihe ndị ana - eme ka ihe dị n’ime ala na - arụ ọrụ. Ọ na - anabata elektrọniki site na ụmụ irighiri ihe ndị ọzọ ma belata. Ọ na - arụkwa ọrụ dị ka coenzyme nke transferase hydride na mkpụrụ nke na - ere NAD (+) polymerase, ma mepụta otu coenzyme redox ya na β-nicotinamide adenine dinucleotide (NADH) belata. NAD (R) bụ ADP-ribose na-enye onyinye unit ribosylation na ADP-A. Ọ bụkwa ihe nrụpụta tupu cyclic ADP-ribose (ADP-ribosyl cyclase).

Dika onye na - eme ihe na - eme ihe na - eme ka ogwu di n’ime ogwu (metabolism) na sel, NAD (R) na - ekerekwa aka na adenosine diphosphate (ADP) - mmeghari mbufe na - etinye polymeria diadenylate (ADP-ribose) na otutu usoro enzymatic ndi ozo. Ọ nwere ike igbochi NAD iji gbochie ma ọ bụ belata ọrịa shuga, kansa na ọrịa ndị ọzọ metụtara afọ. Ọzọkwa, ndị na-eme NAD + na-arụ ọrụ nwere ike ịrụ ọrụ na mgbakwunye nri dịka resveratrol iji nyere aka rejuvenate mitochondria na ịlụ ọgụ nke ọrịa ịka nká.

Nicotinamide adenine dinucleotide(NAD +) uru

Dị ka ezigbo oxidant, Nicotinamide adenine dinucleotide na-egosi na ụfọdụ uru dị mma na ọrụ mmadụ.

Meziwanye ọrụ cellular gị,

♦ Mee ka ume gị dị n'okike;

♦ Meziwanye ọrụ ụbụrụ, mgbado anya na ebe nchekwa;

Na-eme ka ike gwụ gị;

♦ Meziwanye ụra;

♦ Na-eme ka ọrụ sirtuin zuru ụwa ọnụ;

Nwee ikike arụmọrụ antioxidant;

♦ Belata mbufụt;

Balance Nmeziwanye nke oma, onodu, anya na anuru;

Nicotinamide adenine dinucleotid bụkwa ebumnuche doro anya nke ọgwụ ọgwụ estoniazid, nke a na-eji na ọgwụgwọ nke ọrịa kansa, ọrịa nke Mycobacterium ụkwara nta na-akpata. N'ime otu nnwale, ụmụ oke nyere NAD maka otu izu enweela nkwalite nkwukọrịta nuklia-mitochrondrial.

Na mgbakwunye, Nicotinamide adenine dinucleotide (NAD +) nwekwara mgbochi na ọgwụgwọ nke ngọngọ obi, ọrụ sinus na usoro nyocha ngwa ngwa, ihe nicotinamide nwere ike melite ọnụego obi na ngọngọ nke ihe kpatara site na verapamil.

Nicotinamide adenine dinucleotide(NAD +) ngwa:

  1. Diagnostic reagents ngwaọrụ, nyocha sayensị nke nyocha.
  2. Nri mara mma, ihe ntecha, nri nri
  3. Mmepụta API

Ọzọ Nicotinamide adenine dinucleotide(NAD +) nyocha

Enzymes nke na-eme ma na-eji NAD + na NADH dị mkpa na ọgwụ ọgwụ na nyocha maka ọgwụgwọ n'ọdịnihu maka ọrịa. Achọpụtaghị coenzyme NAD + dị ka ọgwụgwọ maka ọrịa ọ bụla. Agbanyeghị, a na-amụ ya maka iji ya eme ihe na ọgwụgwọ nke ọrịa neurodegenerative dị ka ọrịaAlzheimer naParkinson.

Ntughari:

  • Belenky P, Bogan KL, Brenner C (2007). "NAD + metabolism na ahụike yana ọrịa" (PDF). Biochem. Sci. 32 (1): 12– doi: 10.1016 / j.tibs.2006.11.006. PMID 17161604. Edebere ya na mbụ (PDF) na 4 Julaị 2009. Ewepụtara ya na 23 Disemba 2007
  • Todisco S, Agrimi G, Castegna A, Palmieri F (2006). “Identmata onye na - ebugharị mitochondrial NAD + na Saccharomyces cerevisiae”. J. Biol. Chem. 281 (3): 1524– doi: 10.1074 / jbc.M510425200. PMID 16291748.
  • Lin SJ, Guarente L (Eprel 2003). "Nicotinamide adenine dinucleotide, onye na-ahazi metabolic nke ntụgharị, ịdị ogologo ndụ na ọrịa". Curr. Opin. Cell Biol. 15 (2): 241– doi: 10.1016 / S0955-0674 (03) 00006-1. PMID 12648681.
  • Williamson DH, Lund P, Krebs HA (1967). "Ọnọdụ redox nke nicotinamide-adenine dinucleotide na cytoplasm na mitochondria nke oke oke”. Bioko. J. 103 (2): 514– doi: 10.1042 / bj1030514. PMC 1270436. PMID 4291787.
  • Foster JW, Moat AG (1 Mach 1980). "Nicotinamide adenine dinucleotide biosynthesis na usoro pyridine nucleotide metabolism na usoro microbial". Microbiol. Nkpughe 44 (1): 83– PMC 373235. PMID 6997723.
  • French SW. Mmanya na-egbu egbu na-emerụ imeju na akwara ndị ọzọ site na ibelata NAD⁺ ọkwa achọrọ maka ọrụ deacetylase sirtuin. Exp Mol Pathol. 2016 Apr; 100 (2): 303-6. doi: 10.1016 / j.yexmp.2016.02.004. Epub 2016 Feb 16. PMID: 26896648.
  • Kane AE, Sinclair DA. Sirtuins na NAD + n'ime mmepe na ọgwụgwọ nke Ọrịa Metabolic na Ọrịa. Circ Res. 2018 Sep 14; 123 (7): 868-885. doi: 10.1161 / CIRCRESAHA.118.312498. PMID: 30355082. PMCID: PMC6206880.

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