Nicotinamide adenine dinucleotide (53-84-9)

March 15, 2020
SKU: 53-84-9

Nicotinamide adenine dinucleotide (NAD) bụ onye na-arụ ọrụ na-enyere aka metabolism dị na mkpụrụ ndụ niile dị ndụ. Ọ dị n'ụdị abụọ …….

 


ọnọdụ: Na Production Production
Otu: 25kg / Drum

 

Nicotinamide adenine dinucleotide (53-84-9) vidiyo

Nicotinamide adenine dinucleotide (53-84-9) S.mmezi

Product Name Nicotinamide adenine dinucleotide (NAD +)
Chemical Aha Nadide; coenzyme I; beta-NAD; beta-NAD +; beta-Diphosphopyridine nucleotide; diphosphopyridine nucleotide; Enzopride;
CAS Number 53-84-9
InChIKey BAWFJGJZGIEFAR-NNYOXOHSSA-N
Obere C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N
molekụla Formula C21H27N7O14P2
molekụla arọ 663.4 g / mol
Nkịtị Monoisotopic 663.109123 g / mol
Melting Point 160 ° C (320 ° F; 433 K)
Agba White
Soke iwe 2-8 ° C
Solubility H2O: 50 mg / mL
ngwa Nri mara mma, ihe ntecha, nri nri

 

Gịnị bụ Nicotinamide adenine dinucleotide(NAD +)?

Nicotinamide adenine dinucleotide (NAD) bụ cofactor nke na-enyere aka na metabolism dị na sel niile dị ndụ. Ọ dị n'ụdị abụọ, oxidized (NAD +) na belata (NADH).

Coenzyme NAD +, ụdị oxidized nke NAD, bu ụzọ chọpụta na 1906 site na ndị na-ahụ maka biochemist Arthur Harden na William John Young. A na-agwakọta NAD + site na ụzọ abụọ metabolic, nke enwere ike isi na ụzọ no nosi amino acid mepụta, ma ọ bụ enwere ike mepụta ya site na ntughari mmiri (dịka nicotinamide) laghachi na ụzọ nnapụta nke NAD +. Ọ bụ pyridine nucleotide dị mkpa ma na-arụ ọrụ dị ka cofactor na mkpụrụ maka ọtụtụ usoro mkpụrụ ndụ ekwentị nke metụtara phosphorylation oxidative na mmepụta ATP, mmezi DNA, nhazi iwu nke onyinye mkpụrụ ndụ, ihe ngosipụta akwara intracellular na ọrụ Immunological.

NAD + bụ isi ihe na - anabata ihe ndị ana - eme ka ihe dị n’ime ala na - arụ ọrụ. Ọ na - anabata elektrọniki site na ụmụ irighiri ihe ndị ọzọ ma belata. Ọ na - arụkwa ọrụ dị ka coenzyme nke transferase hydride na mkpụrụ nke na - ere NAD (+) polymerase, ma mepụta otu coenzyme redox ya na β-nicotinamide adenine dinucleotide (NADH) belata. NAD (R) bụ ADP-ribose na-enye onyinye unit ribosylation na ADP-A. Ọ bụkwa ihe nrụpụta tupu cyclic ADP-ribose (ADP-ribosyl cyclase).

Dị ka oxidant na cell metabolism, NAD (R) na-ekerekwa òkè na adenosine diphosphate (ADP) -ribose nyefe mmeghachi omume metụtara diadenylate (ADP-ribose) polymerase na ọtụtụ usoro enzymatic ndị ọzọ. O nwere ike inye NAD mgbochi iji gbochie ma ọ bụ belata ọrịa shuga, ọrịa kansa na ọrịa ndị ọzọ metụtara afọ. Ọzọkwa, ndị na-akwado NAD + nwere ike ịrụ ọrụ synergistically na mgbakwunye dịka resveratrol iji nyere aka rejuvenate mitochondria na ịlụ ọgụ maka ọrịa ịka nká.

 

Nicotinamide adenine dinucleotide(NAD +) uru

Dị ka ezigbo oxidant, Nicotinamide adenine dinucleotide na-egosi na ụfọdụ uru dị mma na ọrụ mmadụ.

Na-eme ka ọrụ cellular gị kacha mma,

Mee ka ike gị dịkwuo ike dị ka o kwesịrị;

Imeziwanye ọrụ ụbụrụ, ilekwasị anya na ebe nchekwa;

Mee ka metabolism gị dịkwuo mma;

Sleep Imeziwanye ụra;

Nkwalite ọrụ sirtuin zuru ụwa ọnụ;

♦ Imeziwanye nrụpụta antioxidant;

Belata mbufụt;

Balance Imeziwanye nguzozi, ọnọdụ, ọhụụ na ịnụ ihe;

Nicotinamide adenine dinucleotid bụkwa ihe mgbaru ọsọ nke ọgwụ isoniazid, nke a na-eji na ọgwụgwọ oftuberculosis, ọrịa nke ụkwara nta Mycobacterium kpatara. N'ime otu nnwale, ụmụ oke nyere NAD maka otu izu emeziwanye nkwukọrịta nuklia-mitochrondrial.

Na mgbakwunye, Nicotinamide adenine dinucleotide (NAD +) nwekwara mgbochi na ọgwụgwọ nke ngọngọ obi, ọrụ sinus na usoro nyocha ngwa ngwa, ihe nicotinamide nwere ike melite ọnụego obi na ngọngọ nke ihe kpatara site na verapamil.

 

Nicotinamide adenine dinucleotide(NAD +) ngwa:

  1. Diagnostic reagents ngwaọrụ, nyocha sayensị nke nyocha.
  2. Nri mara mma, ihe ntecha, nri nri
  3. Mmepụta API

 

Ọzọ Nicotinamide adenine dinucleotide(NAD +) nyocha

Enzyme ndị na-eme ma jiri NAD + na NADH dị mkpa na nkà mmụta ọgwụ na nchọpụta n'ime ọgwụgwọ n'ọdịnihu maka ọrịa. A naghị eji coenzyme NAD + eme ihe ugbu a maka ọgwụgwọ maka ọrịa ọ bụla. Otú ọ dị, a na-amụ ya maka iji ya mee ihe na ọgwụgwọ nke ọrịa na-adịghị na-agwọ ọrịa dịka ọrịa Alzheimer naParkinson.

 

Ntughari:

  • Belenky P, Bogan KL, Brenner C (2007). "NAD + metabolism na ahụike na ọrịa" (PDF). Nddị Biochem. Sci. 32 (1): 12– iche: 10.1016 / j.tibs.2006.11.006. PMID 17161604. Edebere na mbụ (PDF) na 4 Julaị 2009. Weghachite 23 Disemba 2007.
  • Todisco S, Agrimi G, Castegna A, Palmieri F (2006). "Nchọpụta nke transporter NAD + mitochondrial na Saccharomyces cerevisiae". NJ J Biol Chem. 281 (3): 1524– doi: 10.1074 / jbc.M510425200. PMID 16291748.
  • Lin SJ, Guarente L (Eprel 2003). "Nicotinamide adenine dinucleotide, metabolic regulator nke transcription, ogologo ndụ na ọrịa". Curr. Nkwupụta. Cell Biol. 15 (2): 241– iche: 10.1016 / S0955-0674 (03) 00006-1. PMID 12648681.
  • Williamson DH, Lund P, Krebs HA (1967). "Ọnọdụ redox bụ free nicotinamide-adenine dinucleotide na cytoplasm na mitochondria nke oke imeju". Mmiri mmiri ọgwụ. J. 103 (2): 514– doi: 10.1042 / bj1030514. PMC 1270436. PMID 4291787.
  • Foster JW, Moat AG (1 Machị 1980). "Nicotinamide adenine dinucleotide biosynthesis na pyridine nucleotide okirikiri metabolism na microbial usoro". Microbiol. Rev. 44 (1): 83– PMC 373235. PMID 6997723.
  • Asụsụ French SW. Alcoholingụ mmanya na-egbu egbu na-emebi imeju na akụkụ ndị ọzọ site na mbenata ọkwa NAD⁺ chọrọ maka ọrụ deacetylase nke sirtuin. Exp Mol Pathol. 2016 Gị onwe gị; 100 (2): 303-6. ma ọ bụ: 10.1016 / j.yexmp.2016.02.004. Epub 2016 Feb 16. PMID: 26896648.
  • Kane AE, Sinclair DA. Sirtuins na NAD + n'ime mmepe na ọgwụgwọ nke Ọrịa Metabolic na Ọrịa. Circ Res. 2018 Sep 14; 123 (7): 868-885. doi: 10.1161 / CIRCRESAHA.118.312498. PMID: 30355082. PMCID: PMC6206880.