Cycloastragenol ntụ ntụ

April 17, 2020

Cycloastragenol bụ ihe eji eme ihe na - eme ka ihe ndi ozo dị na ahia.

Ihe nkiri cycloastragenol ntụ ntụ (78574-94-4)

Cycloastragenol powder Smmezi

Product Name Cycloastragenol ntụ ntụ
Chemical Aha N / A
Synonyms astrahortrangenin

cyclogalegigenin

GRN510

CAG

Klaasị ọgwụ ọjọọ N / A
CAS Number 78574-94-4
InChIKey WENNXORDXYGDTP-UOUCMYEWSA-N
molekụla Fnhazi C30H50O5
molekụla Wasatọ 490.7 g / mol
Nkịtị Monoisotopic 490.365825 g / mol
esi ebe  N / A
Fna-agbanyeghachi Point N / A
Ọkara Ndụ nke Ndụ N / A
Agba acha ọcha ka beige
Sume  DMSO: 10 mg / mL, doro anya
Sịkwa akwa Tigwe  2-8 ° C
Antinye Cycloastragenol bụ onye nwere ikike telomerase. Ọzọkwa, enwere ike ijikọ ya na mgbochi ịka nká na ọgwụ China.

Overview

Cycloastragenol bụ ihe eji eme ihe na - eme ka ihe ndi ozo dị na ahia. A na-ejikwa ya na okomoko akpukpo ahiri okpokoro na usoro ịchọ mma. Ezubere Cycloastragenol nke mbụ na nri nri na USA na 2007 n'okpuru aha TA-65, ọ bụ ya mere TA 65 ma ọ bụ TA65 ka bụ aha kachasị ewu ewu maka cycloastragenol.

Gịnị bụ Cycloastragenol?

Cycloastragenol bụ molekul sitere na ogwu Astragalus membranaceus. Ejirila ahịhịa Astragalus na ọgwụ China kemgbe ọtụtụ narị afọ. Ndị China kwuru na Astragalus nwere ike ịgbatị ndụ, ọ jikwa ya iji gwọọ ike ọgwụgwụ, nfụkasị ahụ, oyi, ọrịa obi na ọrịa shuga.

Cycloastragenol bụ otu n'ime ihe ndị na-arụ ọrụ na Astragalus. Cycloastragenol nwere usoro kemịkalụ yiri nke ihe ana-akpọ Astragaloside IV, mana ọ dị obere ma nwekwawanye ụba nke bioavas, nke na-enyere aka ị nweta obere ọgwụ. Ejirilarị ya dịka immunostimulant n'ihi ike ya ịba ụba pro protineration nke T lymphocyte. Agbanyeghị, ọ bụ akụrụngwa ya na - emegide ịka nká bụ nke na-abawanye mmasị na mpaghara sayensị.

Cycloastragenol na - akpali mmezi nke mmebi DNA site na telomerase na - arụ ọrụ, enzyme nucleoprotein nke catalyses njikọ na uto nke telomeric DNA. Telomeres bụ obere filaments ma achọta ya na kromosomes. Nọgide na-enwe nkwụsi ike ha na-enyere mkpụrụ ndụ aka izere ịda mmụọ nke ịba ụba na mmụba ebighi ebi karịrị 'Hayflick ịgba' Telomeres na-ebelata oge ọ bụla nke sel nkewa, ma ọ bụ mgbe enwere nrụgide oxidative. Ruo ugbu a, nke a abụwo usoro a na-apụghị izere ezere nke ịka nká.

Usoro nke oru Cycloastragenol

Otutu ihe omumu egosiwo na Nchikota oria nke telomeres na nmekorita na otutu oria na aru oria (oria obi, oria, wdg) ma buru kwa n’iru na onwu n’iru ndi n’ile. Telomeres dị mkpụmkpụ na usoro nke sel nke ọ bụla, ma ọ bụ mgbe enwere nrụgide oxidative. Ruo ugbu a, nke a bụ usoro a na-apụghị izere ezere nke ịka nká.

Telomerase bụ enzyme nucleoprotein nke na-egbochi njikọ na uto nke telomeric DNA ma na-akpali mmezi nke mbibi DNA.

Cycloastragenol na - arụ ọrụ ma na - akpali enzyme a, si otú a na - egbochi mbelata telomere ma na - amụba ọnụọgụ ha. N'ụzọ dị otú a, ọ na-enye ohere ịgbatị telomeres na n'ihi nke a, na-agbatị ndụ ndụ sel.

N'ihi ịdị arọ ya dị ala, Cycloastragenol na-agafe mgbidi ngwa ngwa. Nleta kachasị mma na-enye ohere dị elu, ọbụlagodi na ọnụọgụ dị ala. Ntinyechi ubochi ma obu ya onwe ya, ma obu ya na ya ma obu ya na ya emeju, astragaloside IV, ga - enyere aka igbochi ịka nkenke ma gbasaa ndu ogologo ndu.

Cycloastragenol uru

Astragalus membranaceus so n’etiti ahịhịa ndị kachasị dị na akụkọ ọdịnala ọdịnala ndị ọdịnala ọdịnala nke China dịka ọgwụgwọ eke iji gwọọ ike ọgwụgwụ, nrịanrịa, ọnya, ọrịa kansa, ahịhịa hay, ọrịa strok, ogologo oge wdg. Cycloastragenol bụ mkpụrụ ndụ sitere na ogwu Astragalus membranaceus. Otú ọ dị, uru ndị bụ isi nke cycloastragenol ntụ ntụ dị ka mgbochi nká na mmetụta nkwado na-enweghị isi.

Cycloastragenol na nkwado mgbochi

Enwere ike iji Cycloastragenol chekwaa usoro ahụ ji alụso ọrịa ọgụ, antibacterial, na antiinflammatory, maka ịhapụ oyi nkịtị na usoro iku ume elu. Ejiri ya mee ihe dị ka onye na - eme ka ihe ọ immuneụ immuneụ na - alụso ọrịa ọgụ n'ihi ike ịbawanye ụba nke ọgwụ lymphocyte. Ka osi di, ihe ndi sayensi nwere mmasi kariri odi nma nke nguzogide ndi agadi. Cycloastragenol na-agba DNA ume ka ọ rụzie mmebi site na ibido telomerase ma kwe ka ihe nchebe nuklia jikọta njikọta na uto nke telomere DNA.

Cycloastragenol na mgbochi ịka nká

Mgbochi ịka nká bụ uru pụtara ìhè nke cycloastragenol. Ọ bụghị nanị cycloastragenol na-egbu oge ịka nká, kama nke ahụ, ọ nwekwuru ihe mgbochi, ịmụba nsí mkpụrụ ndụ, ichebe akwara obi, nke sitere na mmiri mmiri astragaloside (Astragaloside Ⅳ).

Uru Cycloastragenol ndị ọzọ

  1. cycloastragenol ntụ ntụ nwere mmetụta n'ịbelata nrụgide na ichebe ahụ pụọ na nrụgide dịgasị iche iche, gụnyere nrụgide anụ ahụ, nke uche, ma ọ bụ nke mmetụta uche;
  2. cycloastragenol ntụ ntụ nwere antioxidants, nke na-echebe mkpụrụ ndụ megide mmebi nke radicals n'efu na-akpata;
  3. cycloastragenol ntụ ntụ nwere mmetụta na wedata ọbara mgbali elu, na-agwọ ọrịa shuga ma na-echebe umeji.

Cycloastragenol ntụ ntụ mmetụta

Ruo ugbu a, enweghị akụkọ ọ bụla ma ọ bụ nyocha nke mmetụta ọjọọ ma ọ bụ mmegide na-ewere mgbakwunye cycloastragenol.

Cycloastragenol mgbakwunye usoro onunu ogwu

Cycloastragenol bụ ihe ọhụrụ na ọ bụghị ọtụtụ ụdị nkwado dị na ahịa, na enweghị ọgwụ akwadoro ka ọ dị. Dabere na ahụmịhe anyị, usoro ọgwụgwọ dịgasị iche iche nwere ebumnuche dịgasị iche, afọ. N'ezie cycloastragenol dị ike karịa Astragaloside IV nke ọgwụ a tụrụ aro bụ 50mg kwa ụbọchị. Ezie maka cycloastragenol, ịwepu site na 10mg ruo 50mg dị mma. Ọ dị mkpa ị ga-ewere ihe karịa ndị okenye nọ n'etiti. Fọdụ na-atụ aro ịmalite site na 5mg kwa ụbọchị, wee tinye nwayọọ nwayọọ. Ebe ọ bụ na cycloastragenol bụ ihe wepụtara n'okike, ọ nwere ike iwe oge iji hụ nsonaazụ ahụ, ihe dị ka ọnwa isii.

Cycloastragenol nchekwa

Somefọdụ ewerewo Cycloastragenol dị ka ọrụ ebube nke ịka nká. Ihe omumu mbu bidoro na-ekwe nkwa, n’igosi na o nwere ikike iwelite telomere ogologo, agbanyeghi enwere nchoputa adighi nyocha ihe omumu. Na mgbakwunye, enwere nchegbu na ị takingụ Cycloastragenol nwere ike ịbawanye ihe ize ndụ nke ụfọdụ ọrịa kansa. Ka osi di, ihe omumu nyocha emebeghi ike inwu oria cancer nke jikọtara ya na iji Cycloastragenol.

Cycloastragenol dị ka onyinye na-ekwe nkwa ịka nká. Ọ bụ ezie na egosighi ya ịbawanye afọ ndụ mana egosiri iji belata afọ dị iche iche metụtara ndị na-arụ ọrụ ndụ. Na mgbakwunye e gosipụtara iji belata ihe ịrịba ama nke ịka nká dị ka ezigbo ahịrị na ahịhịa. O nwekwara ike belata ohere nke ọrịa na-emebi emebi dịka Alzheimer, Parkinson's, retinopathies, na cataracts.

Cycloastragenol ntụ ntụ eji na ngwa

A na-eji Cycloastragenol mee ihe maka ọgwụgwọ, njikwa, mgbochi, & mmelite nke ọrịa, ọnọdụ na mgbaàmà ndị a:

  • mbufụt
  • Apoptosis
  • Homeostasis ọgba aghara
  • A nwekwara ike iji Cycloastragenol maka ebumnuche edepụtara ebe a.

Ejirila ntụ ọka cycloastragenol n'okpuru ala:

  1. Ejiri ya mee ihe n'ubi nri, a na-ejikarị ya agwakọta ihe oriri;
  2. Ejiri ya na ngalaba ngwaahịa ahụike, mmụpụta a na-enyere ahụ mmadụ aka;
  3. Ejiri ya na mpaghara ịchọ mma, dị ka ụdị akụrụngwa, ọ nwere ike ịgwakọta ihe ịchọ mma sitere n'okike.

Reference:

  • Ihe ndi na-egbochi ịka nká nke cycloastragenol nke biotransformation mepụtara.Chen C, Ni Y, Jiang B, Yan S, Xu B, Fan B, Huang H, Chen G.Nat Prod Res. 2019 Sep 9: 1-6. ma ọ bụ: 1080 / 14786419.2019.1662011.
  • Cycloastragenol: Nwa akwukwo akwukwo obi uto nke oria ndi oria. YY Y et al. Gbanwee Ahụike. (2018) Ihe ndi na-egbochi nká nke cycloastragenol nke biotransformation mepụtara. Chen C, Ni Y, Jiang B, Yan S, Xu B, Fan B, Huang H, Chen G. Nat Prod Res. 2019 Sep 9: 1-6. ma ọ bụ: 10.1080 / 14786419.2019.1662011
  • Cycloastragenol nwere ike iweghachite mmechi STAT3 ma kwalite apoptosis paclitaxel na-emetụta mkpụrụ ndụ kansa cancer. Hwang ST, Kim C, Lee JH, Chinnathambi A, Alharbi SA, Shair OHM, Sethi G, Ahn KS. 2019 Jun
  • Astragaloside VI na cycloastragenol-6-O-beta-D-glucoside na-akwalite ọgwụgwọ ọnya na vitro na vivo.Lee SY et al. Phytomedicine. (2018)