NMN ntụ ntụ (1094-61-7)

October 30, 2018

Factorylọ ọrụ anyị nwere ikike ịmepụta ihe karịrị 1370kg Nicotinamide Mononucleotide (nmn) uzuzu kwa ọnwa n'okpuru ọnọdụ GMP.


ọnọdụ: Na Production Production
Otu: 25kg / Drum
ikike: 1370kg / ọnwa

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Product Name Raw Nicotinamide Mononucleotide (NMN) ntụ ntụ
Aha oyiri NAMN, β-NMN, β-Nicotinamide Mononucleotide ma ọ bụ Beta Nicotinamide Mononucleotide; NMN;

beta-NMN

Klaasị ọgwụ ọjọọ Ntinye nri
CAS Number 1094-61-7
InChIKey DAYLJWODMCOQEW-TURQNECASA-N
Usoro Molecular C11H15N2O8P
Molekụla arọ 334.22 g / mol
Nkịtị Monoisotopic 334.056602 g / mol
Ebe mgbaze  166 Celsius C (dec.)
Ebe oyi N / A
Ọkara Ndụ nke Ndụ N / A
Agba White na-acha ọcha ntụ ntụ
Solubility  A na-enye Beta-NMN dịka ihe siri ike. Beta-NMN na-agbasapụ ngwa ngwa na ihe ndị na-emepụta ihe dị ka ethanol, DMSO, na dimethyl formamide. Maka nyocha ndị dị ndụ, anyị na-atụ aro na a ga-akwadebe ihe ngwọta mmiri nke Beta-NMN nke na-enweghị ihe mgbaze site na igbari kristal siri ike na nchekwa mmiri. Solubility nke Beta-NMN na PBS, pH 7.2, bụ ihe dịka 10 mg / ml. Anyị anaghị akwado ịchekwa ihe ngwọta mmiri maka ihe karịrị otu ụbọchị.
Nchekwa Nchekwa  Ime ụlọ okpomọkụ;

Chekwaa -20 Celsius C ruo afọ 2.

ngwa Ihe mgbakwunye nri ịka nká

 

Akụkọ banyere NMN

Nicotinamide mononucleotide (usoro ihe omimi: C11H15N2O8P, nọmba CAS: 1094-61-7, nke a makwaara dị ka NMN, beta-Nicotinamide mononucleotide ma ọ bụ β-NMN) bụ vitamin B3 metabolite [1], nke dị na ahụ mmadụ, na nke nkịtị erimeri dika broccoli na kabeeji n'obere ego [2].

NMN malitere inwe mmasị dị ka ihe mgbakwunye na-edozi ahụ na 2013, mgbe ọmalichara ọmụmụ ihe nke ndị sayensị Harvard mere na ụmụ oke [3,4].

Emepụtara NMN nke mbụ dị ka mgbakwunye maka ụmụ mmadụ na 2015 [5], mana ọ dị oke ọnụ iji rụpụta, rue mgbe e mepụtara usoro iji belata ọnụahịa nrụpụta na ịbawanye ọcha na 2018 [6], bụ ebe a na-ahụ maka ụlọ nyocha arụ ọrụ maka imepụta igwe wee bia na intaneti.

 

Kedu ihe bụ NMN ntụ ntụ?

Nicotinamide mononucleotide (usoro ihe omimi: C11H15N2O8P, nọmba CAS: 1094-61-7, nke a makwaara dị ka NMN, beta-Nicotinamide mononucleotide ma ọ bụ β-NMN) bụ vitamin B3 metabolite [1], nke dị na ahụ mmadụ, na nke nkịtị erimeri dika broccoli na kabeeji n'obere ego [2].

Nicotinamide Mononucleotide (NMN) bụ ihe na -emepụta ihe na-adịkarị na ahụ mmadụ yana ụfọdụ nri. NMN anaghị adịte aka, ma mgbe ejiri ya ọnụ kwuo okwu nwere ike ịkwado ọkwa NAD + n'ime imeju na anụ ahụ.

Nnyocha e mere na nso nso a na-atụ aro na NMN nwere ike ịkwado ahụike obi, mmepụta ume, ahụike ezi uche, yana ahụike na ọkpụkpụ. Otu ihe na-adọrọ mmasị na nchọta NMN bụ na ọ nwere ike ịkwalite mmezi DNA ma kwado ọrụ nke mkpụrụ ndụ ihe nketa SIRTUIN nke a na-eche na ọ ga-ekere òkè na ịka nká.

 

Kedu ka esi arụ ọrụ?

NMN bu ihe mbu nke molekul NAD +; ahụ mmadụ chọrọ NMN iji mee NAD + nke ya.

NAD + bụ ụdị oxidized nke NAD (Nicotinamide adenine dinucleotide), ihe omimi nke achọpụtara na 1906, ma chọta ya na mkpụrụ ndụ niile dị ndụ [7].

Gbakwunye na NAD + n'onwe ya abụghị nhọrọ iji bulie ogo NAD, n'ihi na ọ buru oke ibu iji banye mpempe sel iji banye sel, yabụ agaghị enwe ike imetụta metabolism [8] nke ọma.

 

NMN uru.

Otu ụzọ anyị nwere ike isi jigide ọkwa ahụike nke NAD + bụ ịgbakwunye ahụ anyị na nke bu ụzọ, nicotinamide mononucleotide (NMN).

Nnyocha a na-eme ugbu a na-egosi na mgbanwe a n'etiti NR na NMN ga-ewere ọnọdụ maka ịbanye na ụdị sel ole na ole. Nke a na - eme ka ndị nchọpụta kwenye na NMN bụ, n’ezie, otu n’ime ụzọ kachasị ọsọ iji mepụta mmepụta NAD. Otú ọ dị, Nicotinamide mononucleotide ntụ ntụ na-egosikwa na ha nwere uru nke ịka nká karịa nke NAD mmepụta naanị.

Na mgbakwunye na ụzọ NAD metabolic, NMN ntụ ntụ nwere ike ịgbakwunye ozugbo na sel na-enweghị ịtụgharị na NAD. Ihe omume a na-ekwe omume site na ndị na-edozi ụgbọ njem ọhụụ achọpụtala nke na-abawanye ọnụọgụ mgbe ọkwa NAD kwụsịrị. Na ụdị a, NMN na-enye aka na ike sel ma na-enye ohere nke ọ bụla akpọrọ ọgwụ mgbochi ịka nká nke mkpụrụ ndụ nwere nkwalite zuru oke na ịmaliteghachi.

Chohọrọ ịgbakwunye na ntụ ntụ NMN tinyere NAD na-enye ụzọ dị nnọọ mfe iji kwalite nkwalite mkpụrụ ndụ ma bụrụkwa ụzọ dị ngwa iji mee otu ihe ahụ. Na mgbakwunye, achọpụtara Nicotinamide mononucleotide ntụ ntụ iji melite ọrụ insulin na mmepụta, na-ebute uru ndị ọzọ na-emetụta yana ịmachi glucose. Karịsịa, ihe mgbakwunye NMN nwere ike inyere aka rụọ ọrụ iji belata ọnọdụ metabolic dị ka ọrịa shuga, ọrịa imeju araba, na oke ibu. [11]

 

Uru ndị ọzọ dị na NMN

  • Na-akwalite Vascular Health na Ọbara. [11]
  • Mee ka nkwonkwo akwara na ike
  • Na-egbochi Ọrịa Obi
  • Na-ebelata ihe ize ndụ nke oke ibu. [10]
  • Na-emezi mmezi nke mmezi DNA
  • Na-arụ ọrụ Mitochondrial na-arụ ọrụ. [9]

 

Kedu otu esi eme ka NMN kwụsie ike, dị ọcha, dịkwa mma?

Iji chọpụta otu esi enweta ngwaahịa kwụsiri ike, nke ziri ezi, nke dị ọcha na nke na-adịghị ize ndụ, a na-eme usoro nyocha na nyocha. Enwere ike ịnye akụkọ COA, HPLC na HNMR.

 

Nkwụsi ike ka mma

Site na nyochaa usoro ihe omumu nke Nicotinamide mononucleotide na iji ugwo ugwo na uzo nlebara anya FTIR, achoputara na NMN nwere otu nnu nnu n'ime ya na isi ihe di iche iche nke nnu di n'ime ya bu isi ihe nke NMN. Mmiri, dị ka otu polar molekul, ga-eme ka nnyefe eletriki dị n'ime NMN nke nwere ike ibibi skaị nnu nnu dị ezigbo mma nke NMN. Ọ bụrụ otu a, NMN ga - egosiputa usoro mgbanwe nke na - emebi ngwa ngwa, yabụ ọdịnaya mmiri dị na ngwaahịa na mmiri mmiri na - agagharị na ikuku ga - ebibi isi nke isoelectric nke nnu dị n’ime ala ma weda ịdị ọcha nke NMN. Nke a bụ nnukwu ọganiihu na NMN ntụ ntụ nyocha nyocha, nke ga-abụ otu mmalite ka emeziwanye.

Iji meziwanye nkwụsi ike nke NMN ntụ ntụ n'ime, ndị nchọpụta mepụtara ntụ ntụ NMN ọhụrụ site na nhazi usoro na microscopic.

 

Ike kwụsie ike, ogologo ndụ ndụ.

Phcoker NMN ntụ ntụ dị n'usoro na kọmpat, na-egbochi kọntaktị na mmiri efu na ikuku, na-emewanye nkwụsi ike nke NMN ma na-agbatị ndụ ndụ nke ngwaahịa a. N'adịghị ka akwụkwọ akụkọ NMN microscopic, akwụkwọ nke mbụ nke sawtooth na-egosi ọgba aghara na ezughị oke, yabụ mkpụrụ ndụ ọ bụla ga-enwetakwu ikuku ma banyekwu mmiri.

 

Ọdịdị dị elu, usoro ọgwụgwọ siri ike na usoro mgbanwe.

NMN ntụ ntụ nwere nhazi microscopic dị n'usoro na nke nwere kọmpụta nwere nnukwu njupụta na oke mmiri, nke na-ezere usoro ọgwụgwọ na-adịghị agbanwe agbanwe n'ihi ịwelite ájá na usoro nkwadebe. Kedu ihe ọzọ, ọ ga-emetụta usoro onunu ogwu nke capsules. Ka ọ dị ugbu a, ebe ọ bụ na ọ nwere mmiri ka mma, NMN ntụ ntụ anyị nwere ike inye aka belata oge mmepụta na ọnụahịa nrụpụta n'oge nrụpụta.

 

Meela ya n'ezie n'ezie mma ma dị ọcha

Mkpesa nyocha nke ụlọ nyocha nke atọ kwesịrị ịdị mkpa iji nyochaa njirimara na ịdị ọcha nke NNM. Otu ngwugwu ọ bụla ga-enyocha nyocha onwe onye na ule ndị ọzọ. Akụkọ HNMR na HPLC nwere ike ikwenye na izi ezi, ogo dị elu na ịdị ọcha nke NMN.

 

Phcoker bụ Nicotinamide mononucleotide (NMN) ntụ ntụ

Site na ụlọ ọrụ nke aka anyị, NMN ntụ ntụ kwa ọnwa na-ebute ihe ruru tọn 2.

 

ngwa

Ngosiputa Ngwa:

NMN bụ ihe dị na sel nke sel, NMN bụ monomer molekul , ọ na - egbochi ịka nká, yabụ enwere ike iji ya rụọ ọrụ.

 

Ngwaahịa nlekọta ahụike:

NMN ntụ ntụ nwere ike ịkwadebe site na yist gbaa ụka, chemical njikọ ma ọ bụ na vitro enzymatic catalysis.

NMN ntụ ntụ n'ọtụtụ ebe na ụlọ ọrụ nlekọta ahụike.

 

Ntughari:

[1] Nicotinamide mononucleotide. Site Wikipedia, na free encyclopedia.2019.

[2] Nchịkọta Ogologo nke Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Mills KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y, Redpath P, Migaud ME, Apte RS, Uchida K, Yoshino J, Imai SI. Cell Metab. 2016 Dec 13.

[3] Liningjụ NAD + Na-ebute Ọchịchị Pseudohypoxic Na-emebi Nkwurịta Okwu nuklia-Mitochondrial n'oge nká. Gomes AP, Ahịa NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA. Sel. Ọrịa. 2013 Dec 19; 155 (7): 1624-38. ma ọ bụ: 10.1016 / j.cell.2013.11.037.

[4] Ihe Ọhụrụ — Na Ihe A Na-agbanwe agbanwe — Ihe Na-akpata ingka Nka. David Cameron. Vardlọ Akwụkwọ Ahụike Harvard, Akụkọ & Nnyocha, Disemba 19, 2013

[5] Akpa NAD + echekwara nke na-edozi mmekọrịta protein-protein n'oge ịka nká. Li J, Bonkowski MS, Moniot S, Zhang D, Hubbard BP, Ling AJ, Rajman LA, Qin B, Lou Z, Gorbunova V, Aravind L, Steegborn C, Sinclair DA. Sayensị. 2017 Mar 24; 355 (6331): 1312-1317. ma ọ bụ: 10.1126 / science.aad8242.

[6] Usoro Mwepu Chromatography Nke Nha maka Ọcha nke Nicotinamide Mononucleotide (NMN) site na Sel Bacterial. George Cătălin Marinescu, Roua-Gabriela Popescu & Anca Dinischiotu. Akụkọ sayensị Sayensị Nke 8, Nọmba Nkeji edemede: 4433 (2018).

[7] Nicotinamide adenine dinucleotide. Site Wikipedia, na free akwụkwọ nkà ihe ọmụma. 2019.

[8] Ificationchọpụta onye na-ebugharị NAD + nke dị na Saccharomyces cerevisiae., Todisco S, Agrimi G, Castegna A, Palmieri F. J Biol Chem. 2006 Jenụwarị 20; 281 (3): 1524-31. Epub 2005 Nov 16.

[9] Katalin Sas, Elza Szabó, László Vécsei. Mitochondria, Nsogbu Oxidative na Kynurenine System, na-elekwasị anya na ịka nká na Neuroprotection. Molecules, 2018; DOI: 10.3390 / molekul23010191.

[10] Nicotinamide mononucleotide (NMN) mgbakwunye na-eme ka mmetụta nke oke ibu nne na ụmụ oke: tụnyere mmega ahụ. Uddin GM, Youngson NA, Doyle BM, Sinclair DA, Morris MJ.

[11] Jun Yoshino, Kathryn F. Mills, Myeong Jin Yoon, Shin-ichiro Imai. Nicotinamide Mononucleotide, Key NAD + Intermediate, Na-agwọ Ọrịa Pathophysiology nke Diet- na Afọ Ọrịa Na-arịa Ọrịa Shuga na Mice. Cell Metab, 2011; DOI: 10.1016 / j.cmet.2011.08.014.

[12] Ọgwụ Ọjọọ Ọhụrụ: Nicotinamide Mononucleotide (NMN)