Kedu ihe bụ pyrroloquinoline quinone (pqq)?

Pyrroloquinoline quinone (PQQ) nke a makwaara dị ka methoxatin bụ kọmpụta vitamin na-eme ka nri dị ugbu a n'ọtụtụ ngwa nri. PQQ na-emekwa n’onwe ya na mmiri ara ara mmadụ yana akwara mammalian.

Agbanyeghị, a na-ahụ ya naanị na nkeji nkeji n'ime nri etu a pqq ntụ ntụ Mmepụta dị mkpa iji nweta oke zuru ezu na ahụ.

Achọpụtara PQQ na mbụ dị ka nje (coenzyme) na nje bacteria nke ọrụ ya dịka nke B-Vitamin n’ime mmadụ, ma na-ekere òkè n’ịkwalite uto nke ihe ndị a.

N'ime mmadụ, ọ na-arụ ọrụ ka ihe na-abụghị vitamin nke nwere ọtụtụ uru ahụike.

Nhazi nke Action

Pyrroloquinoline quinone (pqq) gosipụtara ọtụtụ uru ahụike site na usoro dị iche iche dị ka iwu nke ụzọ akara ekwentị, tufuo radicals na arụ ọrụ redox.

Usoro ihe eji eme ihe pqq gunyere:

• Ọ na-emetụta ụzọ mkpụrụ ndụ ihe nketa si arụ ọrụ

Pungroloquinoline quinone nwere ike imetụta otu esi egosipụta ụdị mkpụrụ ndụ ihe nketa dị iche iche na ọkachasị mkpụrụ ndụ ihe nketa dị na ọrụ mitochondria. A na-ekwu na ihe ndị na-egbochi antioxidant ya bụ vitamin C ugboro 100.

Egosipụta mgbakwunye PQQ iji rụọ ọrụ CREB na PGC-1a na-edenye ụzọ na-etinye aka na biogenesis mitochondria.

Ọrụ dị ka ọgwụ antioxidant

Ihe mgbochi pyrroloquinoline quinone (pqq) bụ nke kachasị maka ike ya belata PQQH2 site na mmeghachi omume na mbenata ndị dị ka cysteine, ihe oriri ma ọ bụ nicotinamide adenine dinucleotide phosphate (NADPH).

• Na-egbochi enzymes

Pungroloquinoline quinone na-egbochi enzyme thioredoxin reductase 1 (TrxR1), nke n’aka nke na-akpalite ihe metụtara Nuclear factor erythroid 2 metụtara ihe 2 (Nrf2) na-akwalite mmepụta antioxidant.

A makwaara PQQ ka ọ gbochie mmepe nke quinoproteins (na-emebi protein) nke na-eduga n'ọrịa Parkinson.

Ihe kacha mkpa (PQQ) pungroloquinoline quinone uru

Enwere ọtụtụ pungroloquinoline quinone uru gụnyere:

i. PQQ na-akwalite ọrụ mitochondrial

Mitochondria bụ ihe ndị na - emepụta ike n’ime mkpụrụ ndụ n’ụdị ATP site na iku ume ikuku. A na-akpọkarị ha n'ụlọ elektrik maka ụlọ ọrụ ma ọ bụ ụlọ ọrụ ike.

Mmepụta ume bụ isi ihe na-eme ka mmadụ nwee ike.

Ejirila mitochondrial dysfunction n'ọtụtụ nsogbu dịka uto belata, ike ọgwụgwụ, nsogbu akwara ozi dịka ọrịa obi, ịda mba na ọrịa shuga n'etiti ọnọdụ ahụike ndị ọzọ.

Pyrroloquinoline quinone na-eme ka ọrụ mitochondrial dịkwuo mma site na-akpali mmepụta nke mkpụrụ ndụ mitochondria ọhụrụ (mitochondrial biogenesis). Nke a na-eme site na mmụba nke CAMP na-anabata ihe na-ejikọ protein 1 (CREB) na Peroxisome proliferator-activates receptor-gamma coactivator (PGC) -1alpha, ụzọ nke na-akwalite mgenchondrial biogenesis.

Pyrroloquinoline quinone na-emekwa ka ihe ntụgharị nke na-arụ ọrụ dị ka ọgwụ antioxidant n'ime mitochondria n'ihi ya na-echebe anyị pụọ na nrụgide oxidative.

Pqq na - akpalite enzyme n'ime mitochondria nke na - abawanye mmeputa ike.

N'ihe banyere oke, a kọrọ na ụkọ PQQ na nri ka ọ ghara imebi ọrụ mitochondrial.

pyrroloquinoline quinone uru

ii. Na-egbochi mbufụt

Ọrịa na-adịghị ala ala bụ mgbọrọgwụ nke ọtụtụ nsogbu dịka ọrịa obi na ọrịa shuga. Pyrroloquinoline quinone nwere ihe antioxidant na-enyere ya aka iwepu radical site na-egbochi mbufụt na mmebi nke cell.

Nchọpụta ụfọdụ gosiri nke ahụ Mgbakwunye PQQ na - ebute ntopute dị ịrịba ama n'ọtụtụ ihe nrịba ama dịka nitric oxide n'ime naanị ụbọchị atọ.

N'ime nyocha nke ụmụ oke na-arịa ogbu na nkwonkwo, PQQ nke a na-achịkwa ka ọ na-enye nchebe megide nkwụsị nhụjuanya mgbe ụbọchị iri anọ gasịrị.

iii. Ọ na - eme ka ahụ ụbụrụ na arụ ọrụ

Pyrroloquinoline quinone nwere ikike itolite ụbụrụ ọzọ (neurogenesis) site na imepụta ọtụtụ ihe na-akpata akwara.

Otu nnyocha kwubiri na mgbakwunye pqq na-akpali njikọta akwara na-eto eto (NGF) na mkpụrụ ndụ neuron.

Ejikọtara quinone nke Pyrroloquinoline na ikike ncheta na mmụta n'ihi ikike ịhazigharị mkpụrụ ndụ ụbụrụ.

N'ime ọmụmụ nke nwere 41 dị mma mana ndị agadi, PQQ nke enyere na 20 mg / ụbọchị maka izu iri na abụọ ka a na-egbochi mbelata ọrụ ụbụrụ, karịa nke a na ntinye uche na ebe nchekwa.

Pyrroloquinoline quinone nwekwara ike inye aka gbochie mmerụ ahụ ụbụrụ.

Na 2012, nyocha nke oke nyere pqq maka ụbọchị 3 tupu mmerụ ahụ ụbụrụ hụrụ na mgbakwunye ahụ nwere ike ichebe mkpụrụ ndụ ụbụrụ megide mmerụ ahụ a.

iv. PQQ na-akwalite ura

Ihe pyrroloquinoline quinone (PQQ) na-enyere aka ịbawanye ụra ụra gị site na ibelata oge eji ehi ụra, na-eme ka oge ụra hie ụra ma melite ogo ụra zuru oke.

Pungroloquinoline quinone nwekwara ike belata ogo nke hormone ahụ na-akpata nchekasị (cortisol) n'ime ndị mmadụ, ma si otú a mee ka ụra ha ka mma.

N'ime ihe ọmụmụ nke ndị okenye 17, a chọpụtara PQQ nyere na 20 mg / ụbọchị maka izu asatọ iji melite ogo ụra n'ụdị nke oge ihi ụra na obere ụra oge.

PQQ na-akwalite ura

v. Mma ahụike obi

Ikike nke pyrroloquinoline quinone iji chịkwaa ọkwa nke cholesterol na-eme ka ọ belata ihe ize ndụ nke ọrịa obi dịka ọrịa strok.

N'ime nyocha nke ndị okenye 29, ịgbakwunye pqq belatara ọkwa cholesterol ọjọọ LDL dị njọ.

Pyrroloquinoline quinone na -ebelata ọkwa triglycerides nke na-eduga n'ịbawanye arụmọrụ mitochondrial. N'ime ọmụmụ ya na oke, a chọpụtara na ppq nyere belata ọkwa triglyceride ha.

Ihe mgbakwunye Pqq nwere ike inye aka gbochie ma ọ bụ gbanwee atherosclerosis (ọrịa strok). Ihe omumu emere gosiputara na ppq nwere ike wedata protein C-reactive na trimethylamine-N-oxide bu ihe ndi n’egosi nsogbu a.

vi. Onye nwere ike ịdị ogologo ndụ gị niile

A na-ewere quinone Pyrroloquinoline dị ka ihe na-abụghị vitamin, ya mere ọ nwere ike inye aka n'ịkwalite uto gị na mmepe gị.

Ngwongwo Quinone nke Pyrroloquinoline na-alụ ọgụ maka mbufụt, igbochi nrụgide oxidative na ịkwado ọrụ mitochondrial na-egosipụta ike ya ịgbatị ndụ mmadụ.

PQQ nwaputara ime ka uzo ihe ngbanwe nke cell di na ntughari aka nkuku.

Mmetụta mmekọrịta sitere na usoro ndị a na-eme ka PQQ chebe gị pụọ na ịka nká, na-emekwa ka ọ dị ogologo.

Nime usoro anumanu, achoputara pqq ka o wedata uchu nchekari ma mee ka odi ogologo ndu ghari iri.

vii. Nchebe site na nrụgide oxidative

PQQ na - ejikọ protein. Ọ na - enwe ike iwepụ radicals na ahụ.

N'ime ọmụmụ anụmanụ, achọpụtara pqq iji gbochie ọnwụ mkpụrụ ndụ neuron nwụrụ anwụ.

Ọmụmụ ihe ọzọ duziri na vitro kọrọ na PQQ chebere mkpụrụ ndụ mitochondria dịpụrụ adịpụ site na mmebi mgbe nrụgide oxidative ma kpochapụ radiesị superoxide.

Omumu ihe omumu nke ozo eji oria oria shuga na-egbu oria (STZ), PQQ enyere ya aka na 20 mg / kg bodyweight maka ubochi iri na ise ka ewelata onodu mmanu nke glucose na mmanu peroxidation. .

Ozo ndi ozo pungroloquinoline quinone na uru gunyere:

Na-egbochi oke ibu

Na-eme ka usoro ahụ ji alụso ọrịa ọgụ gharazie isi ike

Mma ọmụmụ

Na-akwalite ịrụ ọrụ cognitive na ebe nchekwa

Na enyere aka ike

N'ime ọnọdụ dị ugbu a n'ụwa, akụkọ na-adịghị mma n'ihi COVID 19 na-abịa n'oge ọ bụla. Enwere ike iji Pyrroloquinoline quinone coronavirus ọgụ. Ihe mgbakwunye a na-enye obi ụtọ ga-eme ka ihe ndị ị na - alụso ọrịa ọgụ ghara ịkwalite ma na - enyekwa aka ụra iji belata nchekasị gị.

pyrroloquinoline quinone na-eji

Kedụ nsonaazụ azụ pyrroloquinoline quinone (pqq)?

Mgbe inweta PQQ sitere na nri nri, ọ nweghị mmetụta ọ bụla a na-atụ anya ya belụsọ na mmadụ enweghị nsogbu na nri ụfọdụ.

Na omumu ihe omumu jiri oke, oria akuko ka ejikọtara ya na mgbakwunye PQQ. N’otu ọmụmụ nke gụnyere oke, PQQ gbara ya ume na 11-12 mg / n'arọ ka agwara na akpata akpịrị.

Na nyocha ọzọ nke oke, a chọpụtara PQQ na 20 mg / kg bodyweight ka ọ na-ebute nsí anụ ahụ na akụrụ na hepatic.

Enwekwara ọnụ ọgụgụ dị elu nke ihe dịka 500 mg na-akọ ọnwụ.

N'ime mmadụ, ọ nweghị ọghọm pungroloquinoline quinone mmetụta ka a kọrọ na ọnụọgụ ruru 20 mg / ụbọchị.

Agbanyeghị, n'ọnọdụ ndị a na-adịghị ahụkebe, ụfọdụ pungroloquinoline quinone side nwere ike ime n'ihi ị overụbiga ókè. Mmetụta ndị a gụnyere isi ọwụwa, ike ọgwụgwụ, ụra, ụra, ehighị ụra nke ọma.

Usoro onunu ogwu nke PQQ

Ebe obu na pyrroloquinoline quinone (pqq) akwadobeghi ọgwụ gọọmentị ọgwụ phyroloquinoline quinone, ọ bụ ezie na ụfọdụ ọmụmụ achọpụtala na pyrroloquinoline quinone onunu ogwu site na 2 mg / ụbọchị bara uru. Agbanyeghị, ọtụtụ mgbakwunye PQQ dị na onunu ogwu nke 20 ruo 40 mg.

Pyrroloquinoline quinone usoro onunu ogwu enwere ike ịdị iche iche dabere na ebumnuche ebumnuche. Studiesfọdụ ọmụmụ gosipụtara na usoro onyonyo nke 0.075 ruo 0.3 mg / kg kwa ụbọchị na-arụ ọrụ nke ọma n'ịkwalite ọrụ mitochondria, ebe ọnụọgụ dị elu nke ihe dịka 20 mg kwa ụbọchị nwere ike ịdị mkpa iji lụso mbufụt ọgụ.

Mgbe ejikọtara ya na COQ10, a na-adụ doses nke 20 mg PQQ na 200 mg COQ10, ọ bụ ezie na ụfọdụ ọmụmụ na-eji 20 mg nke PQQ na 300 mg COQ10 agwaghị mmetụta ọjọọ ọ bụla.

A ga-ebu ụzọ mejupụta ihe mgbakwunye PQQ tupu nri - na afọ efu.

A na-adụ gị ọdụ ka ịmalite site na obere doses ma mụbaa dị ka ọ dị mkpa.

Ma marakwa mma bụ na ọtụtụ ọmụmụ anaghị akwado ị takingụ ọgwụ karịrị 80 mg kwa ụbọchị.

Udiri nri ndi nwere pungroloquinoline quinone (pqq)?

Pyrroloquinoline quinone (pqq) dị n'ime ọtụtụ ihe ọkụkụ, n'agbanyeghị na ọ na-abụkarị obere ala. Mkpụrụ osisi ahụ na-enweta PQQ ozugbo site na ahịhịa na ahịhịa ala dịka methylotrophic, rhizobium, na bacteria acetobacter.

Pqq na anụ ahụ mmadụ na-esite na nri site na nri site na ụfọdụ nri na-emetụta nje.

Ogo nke pyrroloquinoline quinine dị na isi nri ndị a dịgasị iche iche site na 0.19 ruo 61ng / g. Ka osi di, pqq kariri ihe oriri ndia:

Pqq-Ihe oriri

Ihe oriri ndi ozo nke PQQ gunyere broccoli puo, mustard ubi, agwa fava, apụl, akwa, achịcha, mmanya na mmiri ara ehi.

N'ihi ọkwa pqq dị ala na ọtụtụ nri, ọ ga-esiri gị ike inweta oke ego iji belata uru metụtara pqq ọ gwụla ma anyị riri oke nri nke otu nri. Ya mere, nke a dị mkpa mmadụ iji zụta mgbakwunye pqq iji meju nri dị mma.

PQQ na COQ10

Coenzyme Q10 (COQ10) a na-ahụkarị ka mitochondria nkwalite na-eme ahụ mmadụ yana n'ọtụtụ nri. O di otua PQQ; agbanyeghị, pyrroloquinoline quinine na CQ10 na-arụ ọrụ n'ụzọ dị iche ma ọ bụ jiri usoro dị iche iche iji melite ọrụ mitochondrial.

Coenzyme Q10 bụ cofactor dị mkpa nke na-arụ ọrụ n'ime mitochondria ma rụọ ọrụ dị mkpa na iku ume cellular na iji oxygen mee ihe maka mmepụta ume. N'aka nke ozo PQQ na-abawanye onu ogugu nke mitochondria ma na - eme ka mitochondria di nma.

Mgbe ejikọtara ọnụ, pyrroloquinoline quinine na CQ10, na-enye nsonaazụ synergetic iji melite ọrụ mitochondrial, na-echebe anyị pụọ na nrụgide oxidative na ịhazi ụzọ akara ekwentị.

Zụta mgbakwunye PQQ

Enwere ọtụtụ uru a na-apụghị izere ezere nke pqq ntụ ntụ ntụ ma ị ga-atụle ịtụle nri gị na ya. PQQ ntụ ntụ maka ịre ere dị n'ịntanetị. Agbanyeghị, maka nsonaazụ kacha mma nwekwuo nlezianya mgbe ịzụrụ pqq emeju iji jide n’aka na ị ga-enweta kacha mma.

Ọ bụrụ na ị na-atụle ịzụ pqq nnukwu ntụ ntụ hụ na ị ga-enweta ya site n'aka ndị na-akwụ ụgwọ kwesịrị ntụkwasị obi.

References

  1. Chowanadisai W., Bauerly KA, Tchaparian E., Wong A., Cortopassi GA, Rucker RB (2010). Pyrroloquinoline quinone na-akpali biogenesis mitochondrial site na nzaghachi cAMP mmewere protein phosphorylation ma mụbaa nkwupụta PGC-1α. Biol. Chem. 285: 142–152.
  2. Harris CB1, Chowanadisai W, Mishchuk DO, Satre MA, Slupsky CM, Rucker RB. (2013). Nri pyrroloquinoline quinone (PQQ) na-agbanwe ihe ngosipụta nke mbufụt na metabolism metụtara metabolism na usoro mmadụ. J Nutr Biochem.Dec 24 (12): 2076-84. Doi: 10.1016 / j.jnutbio.2013.07.008.
  3. Kumazawa T., Sato K., Seno H., Ishii A., na Suzuki O. (1995). Okwa nke pyrroloquinoline quinone na nri dị iche iche. J.307: 331-333.
  4. Nunome K., Miyazaki S., Nakano M., Iguchi-Ariga S., Ariga H. (2008). Pyrroloquinoline quinone na-egbochi ọnwụ nke ụjọ neuronal na-akpata oxidative ma eleghị anya site na mgbanwe na ọnọdụ oxidative nke DJ-1. Mlọ ọgwụ. Ehi. 31: 1321–1326.
  5. Paul Hwang & Darryn S. Willoughby (2018). Usoro eji arụ ọrụ nkwado Pungroloquinoline Quinone na Skeletal Muscle Mitochondrial Biogenesis: Mmetụta Synergistic nwere ike na mmega ahụ, Journal of the American College of Nutrition, 37: 8, 738-748, DOI: 1080 / 07315724.2018.1461146.
  6. Stites T, Storms D, na Bauerly K, et al. (2006). Ederede zuru ezu: Pyrroloquinoline quinone modulates nke oke mitochondrial na arụ ọrụ na ụmụ oke. J Nutr. Fee; 136 (2): 390-6.
  7. Zhang L, Liu J, Cheng C, Yuan Y, Yu B, Shen A, Yan M. (2012). Mmetụta neuroprotective nke pyrroloquinoline quinone na mmerụ ahụ ụbụrụ. J Neurotrauma. Mar 20; 29 (5): 851-64.

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